{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:35:07Z","timestamp":1791408907817,"version":"4.3.3"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL123336"],"award-info":[{"award-number":["U01HL123336"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Coordinating Center","award":["U01HL123339"],"award-info":[{"award-number":["U01HL123339"]}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KOWA Pharmaceuticals"},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1 AI068636"],"award-info":[{"award-number":["UM1 AI068636"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leadership and Operations Center","award":["UM1 AI068634"],"award-info":[{"award-number":["UM1 AI068634"]}]},{"name":"Statistical and Data Management Center","award":["UM1 AI106701"],"award-info":[{"award-number":["UM1 AI106701"]}]},{"name":"Statistical and Data Management Center","award":["R01 AG054366"],"award-info":[{"award-number":["R01 AG054366"]}]},{"name":"Statistical and Data Management Center","award":["P30DK 040561"],"award-info":[{"award-number":["P30DK 040561"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We sought to explore multinational differences in functional status by global burden of disease (GBD) regions in the REPRIEVE cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>REPRIEVE is a prospective, double-blind, randomized, placebo-controlled, multicenter, phase III primary cardiovascular prevention study of pitavastatin calcium vs placebo among people with human immunodeficiency virus (HIV, PWH) ages 40\u201375 on antiretroviral therapy (ART). GBD super regions were defined using World Health Organization classifications. Participants were categorized by impairment on the Duke Activity Status Instrument (DASI: none, some, moderate, severe). Logistic regression models examined risk factors and GBD regions associated with functional impairment. The association between functional impairment and cardiometabolic risk was also explored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 7736 participants, the majority were from high-income countries (n\u2005=\u20054065), were male (65%), and had received ART for\u2005\u2265\u200510 years. The median DASI score was 58.2 (interquartile range [IQR] 50.2, 58.2); 36% reported at least some impairment. In adjusted analyses, functional impairment was significantly more frequent among participants from Southeast\/East Asia. Other factors associated with greater impairment included female sex, Black race, older age, current\/former smoking, higher body mass index, use of ART for\u2005\u2265\u200510 years, and select ART regimens; differences were seen in risks across GBD regions. Functional impairment was associated with increased cardiometabolic risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Over 1\/3 of middle-aged and older PWH in a global cohort across diverse GBD regions demonstrate functional impairments. The associations between DASI and cardiometabolic risk suggest that a measure of functional status may improve risk prediction; these longitudinal associations will be further investigated over REPRIEVE trial follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac098","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T12:14:30Z","timestamp":1643717670000},"page":"1154-1163","source":"Crossref","is-referenced-by-count":9,"title":["Geographical Differences in the Self-Reported Functional Impairment of People With Human Immunodeficiency Virus (HIV) and Associations With Cardiometabolic Risk"],"prefix":"10.1093","volume":"75","author":[{"given":"Kristine M","family":"Erlandson","sequence":"first","affiliation":[{"name":"University of Colorado, Anschutz Medical Campus , Aurora, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen V","family":"Fitch","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A","family":"McCallum","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J","family":"Ribaudo","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. 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Chan School of Public Health , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar T","family":"Overton","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham , Birmingham, Alabama , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markella V","family":"Zanni","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald S","family":"Bloomfield","sequence":"additional","affiliation":[{"name":"Duke Global Health Institute , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd T","family":"Brown","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J","family":"Fichtenbaum","sequence":"additional","affiliation":[{"name":"University of Cincinnati , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bares","sequence":"additional","affiliation":[{"name":"Specialty Care Center, Nebraska Medical Center , Omaha, Nebraska , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A","family":"Aberg","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai , New York, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S","family":"Douglas","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelynne S","family":"Fulda","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L","family":"Santana-Bagur","sequence":"additional","affiliation":[{"name":"Proyecto ACTU , San Juan , Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G","family":"Castro","sequence":"additional","affiliation":[{"name":"University of Miami Infectious Disease Research Unit At Jackson Memorial Hospital , Miami, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E","family":"Moran","sequence":"additional","affiliation":[{"name":"Social & Scientific Systems, a DLH Company , Silver Spring, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Mave","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College, Johns Hopkins University Clinical Research Site , Pune, Maharashtra , 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