{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:41:15Z","timestamp":1782470475635,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"McMaster Medicine Specialty Resident and Fellows Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality gap. Clinicians should acknowledge the possibility of a lower treatment effect when applying RCT results to bedside care.<\/jats:p>","DOI":"10.1093\/cid\/ciac177","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T20:10:34Z","timestamp":1646165434000},"page":"1449-1452","source":"Crossref","is-referenced-by-count":17,"title":["How Generalizable Are Randomized Controlled Trials (RCTs) in <i>Staphylococcus aureus<\/i> Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-9934","authenticated-orcid":false,"given":"Anthony D","family":"Bai","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Queen\u2019s University , Kingston, Ontario , Canada"},{"name":"Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson K L","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-7701","authenticated-orcid":false,"given":"Adam S","family":"Komorowski","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University , Hamilton, Ontario , Canada"},{"name":"Division of Medical Microbiology, Department of Pathology and Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Suresh","sequence":"additional","affiliation":[{"name":"Michael G. 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