{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:44:15Z","timestamp":1791740655681,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170543"],"award-info":[{"award-number":["82170543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770566,"],"award-info":[{"award-number":["81770566,"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000599"],"award-info":[{"award-number":["82000599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Sichuan Science and Technology Department","award":["2019YFS0029"],"award-info":[{"award-number":["2019YFS0029"]}]},{"name":"Science and Technology Program of Sichuan Science and Technology Department","award":["2019YFS0529"],"award-info":[{"award-number":["2019YFS0529"]}]},{"name":"New Medical Technology Foundation of West China Hospital of Sichuan University","award":["XJS2016004"],"award-info":[{"award-number":["XJS2016004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ex vivo liver resection and autotransplantation (ELRA) has shown promising outcomes in treating end-stage hepatic alveolar echinococcosis (AE). However, the actual benefits and risks remain unclear. This study aims to analyze the benefits and risks of ELRA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort analysis included 228 patients with end-stage hepatic AE who underwent ELRA or nonsurgical treatment between 2014 and 2020. Propensity score matching was used. Long-term survival was compared in the matched cohorts using Kaplan-Meier curves generated with the log-rank test. Short-term mortality in entire cohort was predicted based on the nonsurgical group, and the interaction between the predicted mortality risk and observed mortality was tested. Risk factors for postoperative major morbidity in the ELRA group were evaluated using logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The long-term overall survival of the ELRA group was superior to that of the nonsurgical group (82.1% vs 19.1%, 5-year survival). Regarding short-term outcomes, the basic risk of 12-month mortality exerted a significant effect on the benefit of ELRA in entire cohort (per 1%, odds ratio, 1.043; 95% confidence interval [CI]: 1.007\u20131.082; P\u2005=\u2005.021). Patients with a predicted 12-month mortality risk &amp;gt;75% would significantly benefit from ELRA. Combined resection (hazard ratio [HR], 3.32; 95% CI: 1.01\u201310.99; P\u2005=\u2005.049) and overall surgery time (per hour, HR, 1.41; 95% CI: 1.09\u20131.82; P\u2005=\u2005.009) were identified as independent risk factors for postoperative major morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ELRA was significantly beneficial in selected patients with end-stage AE compared with nonsurgical treatment. The timing of conducting ELRA remarkably affected the short-term risk of mortality and should be carefully determined.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciac195","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T20:12:10Z","timestamp":1646770330000},"page":"1289-1296","source":"Crossref","is-referenced-by-count":15,"title":["Evaluating the Benefits and Risks of Ex Vivo Liver Resection and Autotransplantation in Treating Hepatic End-stage Alveolar Echinococcosis"],"prefix":"10.1093","volume":"75","author":[{"given":"Yiwen","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University , Chengdu , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, West China Hospital of Sichuan University , Chengdu , P. R. 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