{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:25:20Z","timestamp":1781774720282,"version":"3.54.5"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ECTZ62340"],"award-info":[{"award-number":["ECTZ62340"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Extended-spectrum \u03b2-lactamase\u2013producing Enterobacterales (ESBL-E) represent a major threat to public health. Little is known on their potential for sexual transmission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We recruited individuals at a sexually transmitted infection and human immunodeficiency virus (HIV) outpatient clinic in Paris, France, in whom we evaluated the prevalence of ESBL-E intestinal carriage and, among those testing positive, the proportion with clearance 6 months thereafter. We compared carriage prevalence between groups using logistic regression adjusted for age, geographic origin, travel outside Europe, and antibiotic use in the past 6 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2157 individuals participated, of whom 226 (10.5%) were ESBL-E carriers. The proportions of ESBL-E carriers varied across sexual groups and were as follows: HIV-negative men who have sex with men (MSM) and who were on preexposure prophylaxis (PrEP), 16.3% (41 of 251); HIV-negative MSM not on PrEP, 9.7% (47 of 487); HIV-positive MSM, 12.2% (61 of 500); HIV-negative men who have sex exclusively with women, 10.0% (44 of 439); and HIV-negative women who have sex with men, 6.9% (n\u2005=\u200533 of 480). After adjustment, ESBL-E prevalence was significantly higher in HIV-negative MSM on PrEP (P\u2005&amp;lt;\u2005.001) and HIV-positive MSM (P\u2005=\u2005.01) than in women who have sex with men. A higher number of sexual partners in the past 6 months was associated with ESBL-E carriage after adjustment (P\u2005=\u2005.004). Escherichia coli sequence type 14 and blaSHV-12\u2013producing ESBL-E were observed only in MSM. Of 102 individuals with ESBL-E returning for testing, 26 (25%) had carriage at 6 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>ESBL-E carriage is more frequent in MSM undergoing PrEP or living with HIV and with increasing number of sexual partners. More research is warranted to understand the consequences of ESBL-E carriage in these populations and how transmission can be reduced.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac218","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T20:36:06Z","timestamp":1647549366000},"page":"1556-1564","source":"Crossref","is-referenced-by-count":18,"title":["Evidence of Sexual Transmission of Extended-Spectrum \u03b2-Lactamase\u2013Producing Enterobacterales: A Cross-sectional and Prospective Study"],"prefix":"10.1093","volume":"75","author":[{"given":"Laure","family":"Surgers","sequence":"first","affiliation":[{"name":"GHU AP-HP, Sorbonne Universit\u00e9, Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine , Paris , France"},{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Chiarabini","sequence":"additional","affiliation":[{"name":"GHU AP-HP, Sorbonne Universit\u00e9, Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilhem","family":"Royer","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pr\u00e9vention, Diagnostic et Traitement des Infections, H\u00f4pital Henri Mondor , AP-HP, Cr\u00e9teil , France"},{"name":"LABGeM, G\u00e9nomique M\u00e9tabolique, Genoscope, Institut Fran\u00e7ois Jacob, CEA, CNRS, Universit\u00e9 Paris-Saclay , Evry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayette","family":"Rougier","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine et d\u2019Epid\u00e9miologie Appliqu\u00e9e , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Mercier-Darty","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pr\u00e9vention, Diagnostic et Traitement des Infections, H\u00f4pital Henri Mondor , AP-HP, Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Decr\u00e9","sequence":"additional","affiliation":[{"name":"Sorbonne University, INSERM, Centre d\u2019Immunologie et des Maladies Infectieuses , CIMI Team 13, Paris , France"},{"name":"GHU AP-HP, Sorbonne Universit\u00e9, D\u00e9partement de Microbiologie, H\u00f4pital Saint-Antoine , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Valin","sequence":"additional","affiliation":[{"name":"GHU AP-HP, Sorbonne Universit\u00e9, Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Louis","family":"Woerther","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pr\u00e9vention, Diagnostic et Traitement des Infections, H\u00f4pital Henri Mondor , AP-HP, Cr\u00e9teil , France"},{"name":"LABGeM, G\u00e9nomique M\u00e9tabolique, Genoscope, Institut Fran\u00e7ois Jacob, CEA, CNRS, Universit\u00e9 Paris-Saclay , Evry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Winoc","family":"Decousser","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pr\u00e9vention, Diagnostic et Traitement des Infections, H\u00f4pital Henri Mondor , AP-HP, Cr\u00e9teil , France"},{"name":"EA 7380 Dynamyc, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Girard","sequence":"additional","affiliation":[{"name":"GHU AP-HP, Sorbonne Universit\u00e9, Service des 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