{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:37:02Z","timestamp":1772696222485,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The use of preexposure prophylaxis (PrEP) for the prevention of human immunodeficiency virus (HIV) has raised concerns of increased sexual risk behaviors. These behaviors may be associated with increased incidence of sexually acquired hepatitis C virus (HCV) among gay and bisexual men.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Expanded PrEP Implementation in Communities\u2013New South Wales (EPIC-NSW) study was a cohort study of daily coformulated tenofovir disoproxil fumarate and emtricitabine for HIV prevention. We recruited 9596 people at high risk of HIV acquisition from 31 clinics across New South Wales and the Australia Capital Territory in Australia. We report prior exposure to HCV and incidence in this cohort between 2016 and 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At least 1 HCV test result was available for 8658 (90.2%) participants. These individuals had a median age of 34 years (interquartile range, 28\u201343), most of whom were male (8530, 98.5%), identified as gay (7944, 91.8%), and were born in Australia (51.8%). Prior exposure to HCV was detected among 81 participants at baseline (0.9%; 95% confidence interval [CI]: .71.2). Twenty of 8577 participants were diagnosed with incident infection (rate 0.2\/100 person-years [95% CI: .1\u2013.3\/100 person-years]). They were significantly older (median age 41 years vs 34 years, P\u2005=\u2005.044), and more likely to report methamphetamine use at baseline (incidence rate ratio, 2.7 [95% CI: 1.00\u20137.2]) than those without incident infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this population of PrEP users, HCV prior exposure and incidence were low. With high levels of HCV and HIV testing and treatment, the dual goals of HIV and HCV elimination could be achieved in this population. Clinical Trials Registration: number NCT02870790.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac231","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T21:48:45Z","timestamp":1648158525000},"page":"1497-1502","source":"Crossref","is-referenced-by-count":6,"title":["Low Prior Exposure and Incidence of Hepatitis C in Human Immunodeficiency Virus\u2013Negative Gay and Bisexual Men Taking Preexposure Prophylaxis (PrEP): Findings From the Expanded PrEP Implementation in Communities\u2013New South Wales Prospective Implementation Study"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-9366","authenticated-orcid":false,"given":"Janaki","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Health Systems and Populations, Macquarie University , Sydney, New South Wales , Australia"},{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Vaccher","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Templeton","sequence":"additional","affiliation":[{"name":"Department of Sexual Health Medicine and Sexual Assault Medical Service, Sydney Local Health District, and Central Clinical School, Faculty of Medicine and Health, The University of Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Bavinton","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyi","family":"Jin","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Zablotska","sequence":"additional","affiliation":[{"name":"Western Sydney Sexual Health Centre & Sydney Medical School\u2013Westmead, University of Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Matthews","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Ogilvie","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Yeung","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"Ooi","sequence":"additional","affiliation":[{"name":"Clinic 16, St Leonards , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nila","family":"Dharan","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Baker","sequence":"additional","affiliation":[{"name":"East Sydney Doctors , Darlinghurst, Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Read","sequence":"additional","affiliation":[{"name":"Kirketon Road Centre , Kings Cross, Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Guy","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E","family":"Grulich","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"2022102916080871900_CIT0001","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s15010-016-0975-y","article-title":"Incidence of hepatitis C in HIV positive and negative men who have sex with men 2000-2016: a systematic review and meta-analysis.","volume":"45","author":"Ghisla","year":"2017","journal-title":"Infection"},{"key":"2022102916080871900_CIT0002","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S2468-1253(20)30303-4","article-title":"Prevalence and incidence of hepatitis C virus infection in men who have sex with men: a systematic review and meta-analysis.","volume":"6","author":"Jin","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2022102916080871900_CIT0003","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/cid\/ciy182","article-title":"Effects of pre-exposure prophylaxis for the prevention of human immunodeficiency virus infection on sexual risk behavior in men who have sex with men: a systematic review and meta-analysis.","volume":"67","author":"Traeger","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2022102916080871900_CIT0004","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1097\/QAD.0000000000000834","article-title":"Incidence of sexually transmitted hepatitis C virus infection in HIV-positive men who have sex with men.","volume":"29","author":"Hagan","year":"2015","journal-title":"AIDS"},{"key":"2022102916080871900_CIT0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1071\/SH16141","article-title":"Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review.","volume":"14","author":"Jin","year":"2017","journal-title":"Sex Health"},{"key":"2022102916080871900_CIT0006","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.drugpo.2019.10.007","article-title":"Chemsex is not a barrier to self-reported daily PrEP adherence among PROUD study participants.","volume":"74","author":"O\u2019Halloran","year":"2019","journal-title":"Int J Drug Policy"},{"key":"2022102916080871900_CIT0007","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1007\/s10461-020-02928-9","article-title":"Australian gay and bisexual men who use condoms, PrEP or rarely practise HIV risk reduction with casual sex partners: an analysis of national, behavioural surveillance data, 2017-2018.","volume":"24","author":"Broady","year":"2020","journal-title":"AIDS Behav"},{"key":"2022102916080871900_CIT0008","volume-title":"Pre-Exposure Prophylaxis of HIV with Antiretroviral 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