{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:00:17Z","timestamp":1771660817770,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministry of Health & Welfare, South Korea","award":["HW20C2062"],"award-info":[{"award-number":["HW20C2062"]}]},{"name":"Ministry of Science and ICT, Republic of Korea","award":["NRF-2017M3A9E4061995"],"award-info":[{"award-number":["NRF-2017M3A9E4061995"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Data on the clinical and virological characteristics of the Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are limited. This prospective cohort study compared the characteristics of the Delta variant to other variants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adult patients with mild coronavirus disease 2019 (COVID-19) who agreed to daily saliva sampling at a community isolation facility in South Korea between July and August 2021 were enrolled. Scores of 28 COVID-19-related symptoms were recorded daily. The genomic RNA and subgenomic RNA from saliva samples were measured by real-time reverse-transcription polymerase chain reaction (PCR). Cell cultures were performed on saliva samples with positive genomic RNA results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 141 patients (Delta group, n\u2005=\u2005108 [77%]; non-Delta group, n\u2005=\u200533 [23%]) were enrolled. Myalgia was more common in the Delta group than in the non-Delta group (52% vs 27%, P\u2005=\u2005.03). Total symptom scores were significantly higher in the Delta group between days 3 and 10 after symptom onset. Initial genomic RNA titers were similar between the 2 groups; however, during the late course of disease, genomic RNA titers were higher in the Delta group. Negative conversion of subgenomic RNA was slower in the Delta group (median 9 vs 5 days; P\u2005&amp;lt;\u2005.001). The duration of viral shedding in terms of positive viral culture was also longer in the Delta group (median 5 vs 3 days; P\u2005=\u2005.002).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>COVID-19 patients infected with the Delta variant exhibited prolonged viable viral shedding with more severe symptoms than those infected with non-Delta variants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac239","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T11:08:33Z","timestamp":1648465713000},"page":"e27-e34","source":"Crossref","is-referenced-by-count":23,"title":["Clinical and Virological Characteristics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.617.2 (Delta) Variant: A Prospective Cohort Study"],"prefix":"10.1093","volume":"75","author":[{"given":"Sunghee","family":"Park","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Yun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heedo","family":"Park","sequence":"additional","affiliation":[{"name":"BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine , Seoul , Republic of Korea"},{"name":"Department of Microbiology, Institute for Viral Diseases, Biosafety Center, College of Medicine, Korea University , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Seo","family":"Lim","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongman","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeonghun","family":"Kim","sequence":"additional","affiliation":[{"name":"BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine , Seoul , Republic of Korea"},{"name":"Department of 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