{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:03:48Z","timestamp":1787317428362,"version":"build-2736575974"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19) and vaccine breakthrough infections are common. We determined the effectiveness of \u22653 doses of mRNA vaccine and early monoclonal antibody therapy in reducing disease severity against the Omicron (B.1.1.529) variant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cohort study of consecutive SOT recipients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection referred to our transplant center who were followed for at least 30 days. The primary outcome was supplemental oxygen requirement. Effectiveness of sotrovimab and \u22653 vaccine doses was estimated using adjusted risk ratios (RR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three hundred adult organ transplant recipients were included. Seventy-one patients (24.1%) were hospitalized, 44 (14.9%) required supplemental oxygen, 19 (6.5%) were admitted to the intensive care unit (ICU), 15 (5.1%) required mechanical ventilation (MV), and 13 (4.4%) died. On multivariate analysis, age and multiple comorbidities were risk factors for oxygen requirement. Both receipt of \u22653 vaccine doses prior to SARS-CoV-2 infection and receipt of sotrovimab in the first 7 days of symptom onset was associated with a reduction in the need for supplemental oxygen (RR 0.30 [95% confidence interval {CI}: .17 to .54] and RR 0.24 (95% CI: .1 to .59), respectively]. For sotrovimab, the number needed to treat (NNT) to prevent one patient requiring oxygen was 6.64 (95% CI: 4.56\u201313.66). Both sotrovimab use and having received \u22653 vaccine doses were also associated with a shorter hospitalization length of stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a cohort of SOT recipients with Omicron variant COVID-19 infection, prior receipt of \u22653 mRNA vaccine doses and early monoclonal antibody therapy were independently associated with significantly reduced disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciac324","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T15:22:11Z","timestamp":1650381731000},"page":"2193-2200","source":"Crossref","is-referenced-by-count":55,"title":["Impact of Vaccination and Early Monoclonal Antibody Therapy on Coronavirus Disease 2019 Outcomes in Organ Transplant Recipients During the Omicron Wave"],"prefix":"10.1093","volume":"75","author":[{"given":"Javier T","family":"Solera","sequence":"first","affiliation":[{"name":"Ajmera Transplant Centre, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta G","family":"\u00c1rbol","sequence":"additional","affiliation":[{"name":"Ajmera Transplant Centre, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alshahrani","sequence":"additional","affiliation":[{"name":"Ajmera Transplant Centre, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Bahinskaya","sequence":"additional","affiliation":[{"name":"Ajmera Transplant Centre, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Marks","sequence":"additional","affiliation":[{"name":"Ajmera Transplant Centre, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Humar","sequence":"additional","affiliation":[{"name":"Ajmera Transplant Centre, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Kumar","sequence":"additional","affiliation":[{"name":"Ajmera Transplant Centre, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"2022121911384281100_ciac324-B1","doi-asserted-by":"crossref","first-page":"e4090","DOI":"10.1093\/cid\/ciaa1097","article-title":"COVID-19 in solid organ transplant: a multi-center cohort study","volume":"73","author":"Kates","year":"2021","journal-title":"Clin Infect 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