{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:40:37Z","timestamp":1787316037345,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R01HS019388"],"award-info":[{"award-number":["R01HS019388"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR000122"],"award-info":[{"award-number":["KL2TR000122"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Los Angeles Clinical and Translational Science Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The CLEAR Trial demonstrated that a multisite body decolonization regimen reduced post-discharge infection and hospitalization in methicillin-resistant Staphylococcus aureus (MRSA) carriers. Here, we describe decolonization efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a large, multicenter, randomized clinical trial of MRSA decolonization among adult patients after hospital discharge with MRSA infection or colonization. Participants were randomized 1:1 to either MRSA prevention education or education plus decolonization with topical chlorhexidine, oral chlorhexidine, and nasal mupirocin. Participants were swabbed in the nares, throat, axilla\/groin, and wound (if applicable) at baseline and 1, 3, 6, and 9 months after randomization. The primary outcomes of this study are follow-up colonization differences between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2121 participants, 1058 were randomized to decolonization. By 1 month, MRSA colonization was lower in the decolonization group compared with the education-only group (odds ration [OR] = 0.44; 95% confidence interval [CI], .36\u2013.54; P \u2264 .001). A similar magnitude of reduction was seen in the nares (OR = 0.34; 95% CI, .27\u2013.42; P &amp;lt; .001), throat (OR = 0.55; 95% CI, .42\u2013.73; P &amp;lt; .001), and axilla\/groin (OR = 0.57; 95% CI, .43\u2013.75; P &amp;lt; .001). These differences persisted through month 9 except at the wound site, which had a relatively small sample size. Higher regimen adherence was associated with lower MRSA colonization (P \u2264 .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a randomized, clinical trial, a repeated post-discharge decolonization regimen for MRSA carriers reduced MRSA colonization overall and at multiple body sites. Higher treatment adherence was associated with greater reductions in MRSA colonization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciac402","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T19:18:14Z","timestamp":1654024694000},"page":"e1208-e1216","source":"Crossref","is-referenced-by-count":11,"title":["Chlorhexidine and Mupirocin for Clearance of Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Colonization After Hospital Discharge: A Secondary Analysis of the Changing Lives by Eradicating Antibiotic Resistance Trial"],"prefix":"10.1093","volume":"76","author":[{"given":"Loren G","family":"Miller","sequence":"first","affiliation":[{"name":"Infectious Disease Clinical Outcomes Research Unit, Division of Infectious Disease, Los Angeles Biomedical Research Institute, Harbor\u2013UCLA Medical Center , Torrance, California , 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A","family":"McKinnell","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Outcomes Research Unit, Division of Infectious Disease, Los Angeles Biomedical Research Institute, Harbor\u2013UCLA Medical Center , Torrance, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Health Policy Research Institute, University of California, Irvine School of Medicine , Irvine, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Tjoa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Health Policy Research Institute, University of California, Irvine School of Medicine , Irvine, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Health Policy Research Institute, University of California, Irvine School of Medicine , Irvine, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syma","family":"Rashid","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Health Policy Research Institute, University of California, Irvine School of Medicine , Irvine, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Macias-Gil","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Outcomes Research Unit, Division of Infectious Disease, Los Angeles Biomedical Research Institute, Harbor\u2013UCLA Medical Center , Torrance, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Heim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Health Policy Research Institute, University of California, Irvine School of Medicine , Irvine, 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