{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:05:17Z","timestamp":1791666317028,"version":"4.3.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/100020365","name":"CDC Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012728","name":"Frederick National Laboratory for Cancer Research","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100012728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Long-term persistence of Ebola virus (EBOV) in immunologically privileged sites has been implicated in recent outbreaks of Ebola virus disease (EVD) in Guinea and the Democratic Republic of Congo. This study was designed to understand how the acute course of EVD, convalescence, and host immune and genetic factors may play a role in prolonged viral persistence in semen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort of 131 male EVD survivors in Liberia were enrolled in a case-case study. \u201cEarly clearers\u201d were defined as those with 2 consecutive negative EBOV semen test results by real-time reverse-transcription polymerase chain reaction (rRT-PCR) \u22652 weeks apart within 1 year after discharge from the Ebola treatment unit or acute EVD. \u201cLate clearers\u201d had detectable EBOV RNA by rRT-PCR &amp;gt;1 year after discharge from the Ebola treatment unit or acute EVD. Retrospective histories of their EVD clinical course were collected by questionnaire, followed by complete physical examinations and blood work.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with early clearers, late clearers were older (median, 42.5 years; P &amp;lt; .001) and experienced fewer severe clinical symptoms (median 2, P = .006). Late clearers had more lens opacifications (odds ratio, 3.9 [95% confidence interval, 1.1\u201313.3]; P = .03), after accounting for age, higher total serum immunoglobulin G3 (IgG3) titers (P = .005), and increased expression of the HLA-C*03:04 allele (0.14 [.02\u2013.70]; P = .007).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Older age, decreased illness severity, elevated total serum IgG3 and HLA-C*03:04 allele expression may be risk factors for the persistence of EBOV in the semen of EVD survivors. EBOV persistence in semen may also be associated with its persistence in other immunologically protected sites, such as the eye.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac424","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T19:53:19Z","timestamp":1654026799000},"page":"e849-e856","source":"Crossref","is-referenced-by-count":19,"title":["Risk Factors for Ebola Virus Persistence in Semen of Survivors in Liberia"],"prefix":"10.1093","volume":"76","author":[{"given":"Jonathan","family":"Dyal","sequence":"first","affiliation":[{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"},{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-6355","authenticated-orcid":false,"given":"Aaron","family":"Kofman","sequence":"additional","affiliation":[{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"},{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jomah Z","family":"Kollie","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fankhauser","sequence":"additional","affiliation":[{"name":"ELWA Hospital, Samaritan\u2019s Purse , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeo","family":"Orone","sequence":"additional","affiliation":[{"name":"ELWA Hospital, Samaritan\u2019s Purse , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses J","family":"Soka","sequence":"additional","affiliation":[{"name":"ELWA Hospital, Samaritan\u2019s Purse , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriah","family":"Glaybo","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armah","family":"Kiawu","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Freeman","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Giah","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D","family":"Tony","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mylene","family":"Faikai","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jawara","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuku","family":"Kamara","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kamara","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Flowers","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed L","family":"Kromah","sequence":"additional","affiliation":[{"name":"Men\u2019s Health Screening Program , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodel","family":"Desamu-Thorpe","sequence":"additional","affiliation":[{"name":"Office of Public Health Preparedness and Response, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Graziano","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E","family":"Morales-Betoulle","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah L","family":"Cannon","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, Nebraska , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne L","family":"Linderman","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Plucinski","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rogier","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Evan","family":"Secor","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E","family":"Bowden","sequence":"additional","affiliation":[{"name":"Division of STD Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi","family":"Phillips","sequence":"additional","affiliation":[{"name":"Division of STD Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary N","family":"Carrington","sequence":"additional","affiliation":[{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute , Frederick, Maryland , USA"},{"name":"Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute , Bethesda, Maryland , USA"},{"name":"Ragon Institute of MGH, Massachusetts Institute of Technology and Harvard University , Cambridge, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute , Frederick, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen P","family":"Martin","sequence":"additional","affiliation":[{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute , Frederick, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Pilar","family":"Aguinaga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Meharry Sickle Cell Center, Meharry Medical College , Nashville, Tennessee , USA"},{"name":"Department of Obstetrics and Gynecology, Meharry Sickle Cell Center , Nashville, Tennessee , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mushi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Meharry Sickle Cell Center, Meharry Medical College , Nashville, Tennessee , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L","family":"Haberling","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D","family":"Ervin","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Klena","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Massaquoi","sequence":"additional","affiliation":[{"name":"Ministry of Health , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolbert","family":"Nyenswah","sequence":"additional","affiliation":[{"name":"Ministry of Health , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart T","family":"Nichol","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Chiriboga","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School , Worcester, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond E","family":"Williams","sequence":"additional","affiliation":[{"name":"Center for Global Health, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H","family":"Hinrichs","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, Nebraska , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T","family":"Vonhm","sequence":"additional","affiliation":[{"name":"National Public Health Institute of Liberia , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre E","family":"Rollin","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J","family":"Purpura","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"2023053118481651400_ciac424-B1","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1056\/nejmoa1500306","article-title":"Persistence of Ebola virus in ocular fluid during convalescence","volume":"372","author":"Varkey","year":"2015","journal-title":"N Engl J Med"},{"key":"2023053118481651400_ciac424-B2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/S0140-6736(16)30386-5","article-title":"Late Ebola virus relapse causing meningoencephalitis: a case report","volume":"388","author":"Jacobs","year":"2016","journal-title":"Lancet"},{"key":"2023053118481651400_ciac424-B3","doi-asserted-by":"publisher","first-page":"S287","DOI":"10.1093\/infdis\/jiy280","article-title":"Ebola virus transmission caused by persistently infected survivors of the 2014\u20132016 outbreak in West Africa","volume":"218","author":"Subissi","year":"2018","journal-title":"J Infect Dis"},{"key":"2023053118481651400_ciac424-B4","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1086\/514318","article-title":"Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo","volume":"179","author":"Rowe","year":"1999","journal-title":"J Infect Dis"},{"key":"2023053118481651400_ciac424-B5","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1056\/nejmoa1511410","article-title":"Ebola RNA persistence in semen of Ebola virus disease survivors\u2014final report","volume":"377","author":"Deen","year":"2017","journal-title":"N Engl J Med"},{"key":"2023053118481651400_ciac424-B6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1056\/NEJMoa1805435","article-title":"A longitudinal study of Ebola sequelae in Liberia","volume":"380","author":"Prevail III Study Group","year":"2019","journal-title":"N Engl J Med"},{"key":"2023053118481651400_ciac424-B7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41586-021-03901-9","article-title":"Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks","volume":"597","author":"Keita","year":"2021","journal-title":"Nature"},{"key":"2023053118481651400_ciac424-B8","doi-asserted-by":"publisher","first-page":"e736","DOI":"10.1016\/S2214-109X(16)30175-9","article-title":"Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data","volume":"4","author":"Soka","year":"2016","journal-title":"Lancet Global Health"},{"key":"2023053118481651400_ciac424-B9","doi-asserted-by":"publisher","first-page":"e1003273","DOI":"10.1371\/journal.pmed.1003273","article-title":"Persistence of Ebola virus in semen among Ebola virus disease survivors in Sierra Leone: a cohort study of frequency, duration, and risk factors","volume":"18","author":"Thorson","year":"2021","journal-title":"PLoS Med"},{"key":"2023053118481651400_ciac424-B10","author":"World Health Organization"},{"key":"2023053118481651400_ciac424-B11","doi-asserted-by":"publisher","first-page":"e3641","DOI":"10.1093\/cid\/ciaa1331","article-title":"Characteristics of Ebola virus disease survivor blood and semen in Liberia: serology and reverse transcription polymerase chain reaction (RT-PCR)","volume":"73","author":"Kofman","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2023053118481651400_ciac424-B12","author":"Centers for Disease Control and Prevention"},{"key":"2023053118481651400_ciac424-B13","author":"Centers for Disease Control and Prevention"},{"key":"2023053118481651400_ciac424-B14","doi-asserted-by":"publisher","first-page":"e0005265","DOI":"10.1371\/journal.pntd.0005265","article-title":"Predicting Ebola severity: a clinical prioritization score for Ebola virus disease","volume":"11","author":"Hartley","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"2023053118481651400_ciac424-B15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/sj.ijir.3901327","article-title":"The Sexual Health Inventory for Men (SHIM): a 5-year review of research and clinical experience","volume":"17","author":"Cappelleri","year":"2005","journal-title":"Int J Impotence Res"},{"issue":"3","key":"2023053118481651400_ciac424-B16","doi-asserted-by":"publisher","first-page":"ofx155","DOI":"10.1093\/ofid\/ofx155","article-title":"Ebola virus ribonucleic acid detection in semen more than two years after resolution of acute Ebola virus infection","volume":"4","author":"Fischer","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"2023053118481651400_ciac424-B17","doi-asserted-by":"publisher","first-page":"S188","DOI":"10.1086\/514283","article-title":"Markedly elevated levels of interferon (IFN)-\u03b3, IFN-\u03b1, interleukin (IL)-2, IL-10, and tumor necrosis factor-\u03b1 associated with fatal Ebola virus infection","volume":"179","author":"Villinger","year":"1999","journal-title":"J Infect Dis"},{"key":"2023053118481651400_ciac424-B18","doi-asserted-by":"publisher","first-page":"e837","DOI":"10.1371\/journal.pntd.0000837","article-title":"Human fatal Zaire Ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis","volume":"4","author":"Wauquier","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"2023053118481651400_ciac424-B19","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/7422","article-title":"Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients","volume":"5","author":"Baize","year":"1999","journal-title":"Nat Med"},{"key":"2023053118481651400_ciac424-B20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jhep.2016.03.016","article-title":"Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C\u221703:04 and modulate NK cell function","volume":"65","author":"Lunemann","year":"2016","journal-title":"J Hepatol"},{"key":"2023053118481651400_ciac424-B21","doi-asserted-by":"publisher","first-page":"e1001900","DOI":"10.1371\/journal.pmed.1001900","article-title":"Selection of an HLA-C*03:04-restricted HIV-1 p24 gag sequence variant is associated with viral escape from KIR2DL3+ natural killer cells: data from an observational cohort in South Africa","volume":"12","author":"H\u00f6lzemer","year":"2015","journal-title":"PLoS Med"},{"key":"2023053118481651400_ciac424-B22","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00251-010-0480-x","article-title":"Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection","volume":"62","author":"Wauquier","year":"2010","journal-title":"Immunogenetics"},{"key":"2023053118481651400_ciac424-B23","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3201\/EID2701.202177","article-title":"Human diversity of killer cell immunoglobulin-like receptors and human leukocyte antigen class I alleles and Ebola virus disease outcomes","volume":"27","author":"Wawina-Bokalanga","year":"2021","journal-title":"Emerging Infect Dis"},{"key":"2023053118481651400_ciac424-B24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/imcb.12298","article-title":"Systems immunology reveals a linked IgG3\u2013C4 response in patients with acute rheumatic fever","volume":"98","author":"Chung","year":"2020","journal-title":"Immunol Cell Biol"},{"key":"2023053118481651400_ciac424-B25","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.celrep.2018.07.035","article-title":"Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors","volume":"24","author":"Kuzmina","year":"2018","journal-title":"Cell Rep"},{"key":"2023053118481651400_ciac424-B26","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abi5229","article-title":"Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors","volume":"14","author":"Liu","year":"2022","journal-title":"Sci Transl Med"},{"key":"2023053118481651400_ciac424-B27","author":"World Health Organization"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciac424\/44439633\/ciac424.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/3\/e849\/50496762\/ciac424.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/3\/e849\/50496762\/ciac424.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T18:48:32Z","timestamp":1685558912000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/76\/3\/e849\/6594055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,27]]},"published-print":{"date-parts":[[2023,2,8]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciac424","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,5,27]]}}}