{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:54:41Z","timestamp":1772754881684,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The objective was to estimate risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy and assess adverse maternal and perinatal outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used a population-based, retrospective cohort of all pregnancies with a live birth or fetal death in Florida from 1 March 2020 to 30 April 2021. Coronavirus disease 2019 (COVID-19) case reports were matched to vital registries. Outcomes assessed were risk of infection in pregnancy, preterm birth, maternal or neonatal admission to an intensive care unit (ICU), perinatal or fetal death, and maternal death. Modified Poisson and multinomial logistic regression models were used to derive relative risk estimates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 234\u2009492 women with a live birth or fetal death during the study period, 12\u2009976 (5.5%) were identified with COVID-19 during pregnancy. Risk factors for COVID-19 in pregnancy included Hispanic ethnicity (relative risk [RR]\u2009=\u20091.89), Black race (RR\u2009=\u20091.34), being unmarried (RR\u2009=\u20091.04), and being overweight or obese pre-pregnancy (RR\u2009=\u20091.08\u20131.32). COVID-19 during pregnancy was associated with preterm birth (RR\u2009=\u20091.31), Cesarean delivery (RR\u2009=\u20091.04), and neonatal (RR\u2009=\u20091.17) and maternal (RR\u2009=\u20093.10) ICU admission; no association was found with increased risk of perinatal (RR\u2009=\u20090.72) or fetal death (RR\u2009=\u20090.86). Women infected during any trimester showed increased risk of preterm birth. Fourteen maternal deaths were identified among COVID-19 cases; of those who died, 12 were obese. The death rate per 10\u2009000 was 22.09 among obese and 1.22 among non-obese gravida with COVID-19 during pregnancy (RR\u2009=\u200918.99, P\u2009=\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Obesity is a risk factor for SARS-CoV-2 infection in pregnancy and for more severe COVID-19 illness among pregnant women. SARS-CoV-2 infection is associated with preterm birth.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac441","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T17:29:59Z","timestamp":1654709399000},"page":"S308-S316","source":"Crossref","is-referenced-by-count":19,"title":["Maternal and Perinatal Outcomes Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection During Pregnancy, Florida, 2020\u20132021: A Retrospective Cohort Study"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-9157","authenticated-orcid":false,"given":"Timothy J","family":"Doyle","sequence":"first","affiliation":[{"name":"Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee , Florida , USA"},{"name":"Center for Preparedness and Response, Centers for Disease Control and Prevention, Atlanta , Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gebre egziabhe","family":"Kiros","sequence":"additional","affiliation":[{"name":"Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee , Florida , USA"},{"name":"College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida Agricultural and Mechanical University , Tallahassee, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily N","family":"Schmitt-Matzen","sequence":"additional","affiliation":[{"name":"Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee , Florida , USA"},{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy","family":"Propper","sequence":"additional","affiliation":[{"name":"Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee , Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Community Health Promotion, Florida Department of Health , Tallahassee, Florida , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghasi S","family":"Phillips-Bell","sequence":"additional","affiliation":[{"name":"Division of Community Health Promotion, Florida Department of Health , Tallahassee, Florida , USA"},{"name":"Division of Reproductive Health, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"2022100314593090000_ciac441-B1","doi-asserted-by":"crossref","first-page":"m3320","DOI":"10.1136\/bmj.m3320","article-title":"Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis","volume":"370","author":"Allotey","year":"2020","journal-title":"BMJ"},{"key":"2022100314593090000_ciac441-B2","doi-asserted-by":"crossref","first-page":"E540","DOI":"10.1503\/cmaj.202604","article-title":"The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis","volume":"193","author":"Wei","year":"2021","journal-title":"CMAJ"},{"key":"2022100314593090000_ciac441-B3","doi-asserted-by":"crossref","first-page":"109.e1","DOI":"10.1016\/j.ajog.2020.04.030","article-title":"Maternal death due to COVID-19","volume":"223","author":"Hantoushzadeh","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"2022100314593090000_ciac441-B4","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1001\/jama.2020.7233","article-title":"Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 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outcomes","volume":"325","author":"Norman","year":"2021","journal-title":"JAMA"},{"key":"2022100314593090000_ciac441-B24","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jamapediatrics.2021.1050","article-title":"Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study","volume":"175","author":"Villar","year":"2021","journal-title":"JAMA Pediatr"},{"key":"2022100314593090000_ciac441-B25","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/uog.23619","article-title":"Pregnancy and neonatal outcomes of COVID-19: coreporting of common outcomes from PAN-COVID and AAP-SONPM registries","volume":"57","author":"Mullins","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2022100314593090000_ciac441-B26","doi-asserted-by":"crossref","first-page":"77.e1","DOI":"10.1016\/j.ajog.2020.12.1221","article-title":"Disease severity, pregnancy outcomes, and maternal deaths 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