{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:43:48Z","timestamp":1790819028073,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>During the past 4 decades, oral vancomycin has been a mainstay of Clostridioides difficile infection (CDI) therapy with no reports of treatment failure due to emergence of vancomycin resistance. However, C. difficile isolates with high-level phenotypic resistance to vancomycin have recently been reported in 3 distinct geographic regions. There is an urgent need for surveillance to determine if strains with reduced vancomycin susceptibility are circulating in other areas. In a Cleveland-area hospital, screening of 176 CDI stool specimens yielded no C. difficile isolates with reduced vancomycin susceptibility and highlighted the potential for false-positive results due to contamination with vancomycin-resistant enterococci. Additional studies are needed to clarify whether reduced vancomycin susceptibility is an emerging problem that will alter clinical practice. Clinicians should alert their health department if they observe a substantial increase in the frequency of vancomycin treatment failure in patients diagnosed with CDI with no alternative explanation for diarrhea.<\/jats:p>","DOI":"10.1093\/cid\/ciac444","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T17:35:41Z","timestamp":1654191341000},"page":"1661-1664","source":"Crossref","is-referenced-by-count":15,"title":["Houston, We Have a Problem: Reports of <i>Clostridioides difficile<\/i> Isolates With Reduced Vancomycin Susceptibility"],"prefix":"10.1093","volume":"75","author":[{"given":"David Henry","family":"Greentree","sequence":"first","affiliation":[{"name":"Departments of Biology and Medical Anthropology, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis B","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Medicine, Warren Alpert Medical 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