{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:59:42Z","timestamp":1792216782768,"version":"4.4.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","award":["GT12053"],"award-info":[{"award-number":["GT12053"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"crossref","award":["HATFUL19GO"],"award-info":[{"award-number":["HATFUL19GO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"crossref","award":["NICK20Y2-SVC"],"award-info":[{"award-number":["NICK20Y2-SVC"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"crossref","award":["NICK20Y2-OUT"],"award-info":[{"award-number":["NICK20Y2-OUT"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["K08 HL139994-01"],"award-info":[{"award-number":["K08 HL139994-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","award":["HL146228"],"award-info":[{"award-number":["HL146228"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","award":["NICK20Y2-SVC and NICK20Y2-OUT"],"award-info":[{"award-number":["NICK20Y2-SVC and NICK20Y2-OUT"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["GM131729"],"award-info":[{"award-number":["GM131729"]}]},{"name":"NIH","award":["AI154546"],"award-info":[{"award-number":["AI154546"]}]},{"name":"NIH","award":["R01HL146228"],"award-info":[{"award-number":["R01HL146228"]}]},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Nontuberculous Mycobacterium infections, particularly Mycobacterium abscessus, are increasingly common among patients with cystic fibrosis and chronic bronchiectatic lung diseases. Treatment is challenging due to intrinsic antibiotic resistance. Bacteriophage therapy represents a potentially novel approach. Relatively few active lytic phages are available and there is great variation in phage susceptibilities among M. abscessus isolates, requiring personalized phage identification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Mycobacterium isolates from 200 culture-positive patients with symptomatic disease were screened for phage susceptibilities. One or more lytic phages were identified for 55 isolates. Phages were administered intravenously, by aerosolization, or both to 20 patients on a compassionate use basis and patients were monitored for adverse reactions, clinical and microbiologic responses, the emergence of phage resistance, and phage neutralization in serum, sputum, or bronchoalveolar lavage fluid.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No adverse reactions attributed to therapy were seen in any patient regardless of the pathogen, phages administered, or the route of delivery. Favorable clinical or microbiological responses were observed in 11 patients. Neutralizing antibodies were identified in serum after initiation of phage delivery intravenously in 8 patients, potentially contributing to lack of treatment response in 4 cases, but were not consistently associated with unfavorable responses in others. Eleven patients were treated with only a single phage, and no phage resistance was observed in any of these.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Phage treatment of Mycobacterium infections is challenging due to the limited repertoire of therapeutically useful phages, but favorable clinical outcomes in patients lacking any other treatment options support continued development of adjunctive phage therapy for some mycobacterial infections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac453","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T05:11:20Z","timestamp":1654751480000},"page":"103-112","source":"Crossref","is-referenced-by-count":356,"title":["Phage Therapy of <i>Mycobacterium<\/i> Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease"],"prefix":"10.1093","volume":"76","author":[{"given":"Rebekah M","family":"Dedrick","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey E","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Cristinziano","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista G","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Jacobs-Sera","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Belessis","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, University of New South Wales , Sydney, New South Wales , Australia"},{"name":"Department of Respiratory Medicine, Sydney Children's Hospital , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Whitney Brown","sequence":"additional","affiliation":[{"name":"Inova Fairfax Hospital , Falls Church, Virginia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keira A","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M","family":"Davidson","sequence":"additional","affiliation":[{"name":"Center for Genes, Environment, and Health, National Jewish Health , Denver, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"van Duin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of North Carolina , Chapel Hill, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gainey","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Pediatric Infectious Diseases, Prisma Health Children's Hospital\u2013Midlands , Columbia, South Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Berastegui","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Hospital Universitari Vall d\u2019Hebron , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C R","family":"Robert George","sequence":"additional","affiliation":[{"name":"New South Wales Health Pathology Microbiology, John Hunter Hospital , New Lambton, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghady","family":"Haidar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology, Great Ormond Street Hospital , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Iredell","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Sydney Children\u2019s Hospital , Randwick, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameneh","family":"Khatami","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology, Children's Hospital at Westmead , Westmead, New South Wales , Australia"},{"name":"Discipline of Child and Adolescent Health, University of Syndey , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S","family":"Little","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Malmivaara","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J","family":"McMullan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Sydney Children\u2019s Hospital , Randwick, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Michalik","sequence":"additional","affiliation":[{"name":"Miller Children\u2019s and Women\u2019s Hospital, Division of Pediatric Infectious Diseases , Long Beach, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Moscatelli","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Instituto Giannina Gaslini , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A","family":"Nick","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health , Denver, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G","family":"Tupayachi Ortiz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Miller School of Medicine, University of Miami , Miami, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari M","family":"Polenakovik","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Dayton Children\u2019s Hospital, Boonshoft School of Medicine, Wright State University , Dayton, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Children's Hospital at Westmead , Westmead, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Skurnik","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Human Microbiome Research Program, University of Helsinki , Helsinki , Finland"},{"name":"Division of Clinical Microbiology, Helsinki University Hospital , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Soothill","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Spencer","sequence":"additional","affiliation":[{"name":"Respiratory Medicine and Cardiothoracic Transplantation, Great Ormond Street Hospital , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wark","sequence":"additional","affiliation":[{"name":"Immune Health Program, Hunter Medical Research Institute, University of Newcastle , Callaghan, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austen","family":"Worth","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology, Great Ormond Street Hospital , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T","family":"Schooley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego , San Diego, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance A","family":"Benson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego , San Diego, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-6821","authenticated-orcid":false,"given":"Graham F","family":"Hatfull","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"2023010809022983800_ciac453-B1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ebiom.2015.12.023","article-title":"Oral phage therapy of acute bacterial diarrhea with two coliphage preparations: a randomized trial in children from Bangladesh","volume":"4","author":"Sarker","year":"2016","journal-title":"EBioMedicine"},{"key":"2023010809022983800_ciac453-B2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1473-3099(18)30482-1","article-title":"Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1\/2 trial","volume":"19","author":"Jault","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"2023010809022983800_ciac453-B3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-med-080219-122208","article-title":"Phage therapy for antibiotic-resistant bacterial infections","volume":"73","author":"Hatfull","year":"2021","journal-title":"Annu Rev Med"},{"key":"2023010809022983800_ciac453-B4","doi-asserted-by":"crossref","first-page":"e00954-17","DOI":"10.1128\/AAC.00954-17","article-title":"Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection","volume":"61","author":"Schooley","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"2023010809022983800_ciac453-B5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/s41591-019-0437-z","article-title":"Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus","volume":"25","author":"Dedrick","year":"2019","journal-title":"Nat Med"},{"key":"2023010809022983800_ciac453-B6","doi-asserted-by":"crossref","first-page":"ofaa389","DOI":"10.1093\/ofid\/ofaa389","article-title":"Lessons learned from the first 10 consecutive cases of intravenous bacteriophage therapy to treat multidrug-resistant bacterial infections at a single center in the United States","volume":"7","author":"Aslam","year":"2020","journal-title":"Open Forum Infect Dis"},{"key":"2023010809022983800_ciac453-B7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/emph\/eoy005","article-title":"Phage treatment of an aortic graft infected with Pseudomonas aeruginosa","volume":"2018","author":"Chan","year":"2018","journal-title":"Evol Med Public Health"},{"key":"2023010809022983800_ciac453-B8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1055\/s-0039-1693706","article-title":"Nontuberculous mycobacteria in cystic fibrosis","volume":"40","author":"Richards","year":"2019","journal-title":"Semin Respir Crit Care Med"},{"key":"2023010809022983800_ciac453-B9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ppul.24604","article-title":"Challenging scenarios in nontuberculous mycobacterial infection in cystic fibrosis","volume":"55","author":"Martiniano","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"2023010809022983800_ciac453-B10","doi-asserted-by":"crossref","first-page":"e02194-18","DOI":"10.1128\/AAC.02194-18","article-title":"A rapid unraveling of the activity and antibiotic susceptibility of mycobacteria","volume":"63","author":"Mustazzolu","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"2023010809022983800_ciac453-B11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chest.2021.07.035","article-title":"Treatment of Mycobacterium abscessus pulmonary disease","volume":"161","author":"Griffith","year":"2022","journal-title":"Chest"},{"key":"2023010809022983800_ciac453-B12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.smim.2014.09.008","article-title":"Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-gamma immunity","volume":"26","author":"Bustamante","year":"2014","journal-title":"Semin Immunol"},{"key":"2023010809022983800_ciac453-B13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/s-0035-1546751","article-title":"Nontuberculous mycobacteria in cystic fibrosis and non-cystic fibrosis bronchiectasis","volume":"36","author":"Park","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"issue":"Suppl 1","key":"2023010809022983800_ciac453-B14","first-page":"S4","article-title":"Bacteriophage therapy for infections in CF","volume":"56","author":"Chan","year":"2021","journal-title":"Pediatr Pulmonol"},{"key":"2023010809022983800_ciac453-B15","doi-asserted-by":"crossref","first-page":"e00973-21","DOI":"10.1128\/mBio.00973-21","article-title":"Towards a phage cocktail for tuberculosis: susceptibility and tuberculocidal action of mycobacteriophages against diverse Mycobacterium tuberculosis strains","volume":"12","author":"Guerrero Bustamante","year":"2021","journal-title":"mBio"},{"key":"2023010809022983800_ciac453-B16","doi-asserted-by":"crossref","first-page":"e1003953","DOI":"10.1371\/journal.ppat.1003953","article-title":"Mycobacteriophages: windows into tuberculosis","volume":"10","author":"Hatfull","year":"2014","journal-title":"PLoS Pathog"},{"key":"2023010809022983800_ciac453-B17","doi-asserted-by":"crossref","first-page":"e03431-20","DOI":"10.1128\/mBio.03431-20","article-title":"Mycobacterium abscessus strain morphotype determines phage susceptibility, the repertoire of therapeutically useful phages, and phage resistance","volume":"12","author":"Dedrick","year":"2021","journal-title":"mBio"},{"key":"2023010809022983800_ciac453-B18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1128\/JCM.01249-13","article-title":"Characterization of rough and smooth morphotypes of Mycobacterium abscessus isolates from clinical specimens","volume":"52","author":"Ruger","year":"2014","journal-title":"J Clin Microbiol"},{"key":"2023010809022983800_ciac453-B19","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s41591-021-01403-9","article-title":"Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection","volume":"27","author":"Dedrick","year":"2021","journal-title":"Nat Med"},{"key":"2023010809022983800_ciac453-B20","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/ciaa1125","article-title":"Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2023010809022983800_ciac453-B21","doi-asserted-by":"crossref","first-page":"e00973-21","DOI":"10.1128\/mBio.00973-21","article-title":"Toward a phage cocktail for tuberculosis: susceptibility and tuberculocidal action of mycobacteriophages against diverse Mycobacterium tuberculosis strains","volume":"12","author":"Guerrero-Bustamante","year":"2021","journal-title":"mBio"},{"key":"2023010809022983800_ciac453-B22","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1038\/s41467-022-29689-4","article-title":"Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection","volume":"13","author":"Little","year":"2022","journal-title":"Nat Commun"},{"key":"2023010809022983800_ciac453-B23","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.cell.2022.04.024","article-title":"Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection","volume":"185","author":"Nick","year":"2022","journal-title":"Cell"},{"key":"2023010809022983800_ciac453-B24","doi-asserted-by":"crossref","first-page":"e03441-20","DOI":"10.1128\/mBio.03441-20","article-title":"The prophage and plasmid mobilome as a likely driver of Mycobacterium abscessus diversity","volume":"12","author":"Dedrick","year":"2021","journal-title":"mBio"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciac453\/47758687\/ciac453.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/1\/103\/48533271\/ciac453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/1\/103\/48533271\/ciac453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T09:03:04Z","timestamp":1673168584000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/76\/1\/103\/6604409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,9]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,6,9]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciac453","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,6,9]]}}}