{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:30:30Z","timestamp":1785843030533,"version":"3.56.0"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"NIH"},{"name":"San Diego Center for AIDS Research"},{"DOI":"10.13039\/100020189","name":"John and Mary Tu Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020189","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010296","name":"James B. Pendleton Charitable Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010296","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We isolated a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2 variant from a person with coronavirus disease 2019 recrudescence after nirmatrelvir\/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing were performed with both parental SARS-CoV-2 and multiple variants of concern. We found that neither nirmatrelvir resistance nor absence of neutralizing immunity was a likely cause of the recrudescence.<\/jats:p>","DOI":"10.1093\/cid\/ciac496","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T12:34:56Z","timestamp":1655728496000},"page":"e530-e532","source":"Crossref","is-referenced-by-count":40,"title":["Virologic and Immunologic Characterization of Coronavirus Disease 2019 Recrudescence After Nirmatrelvir\/Ritonavir Treatment"],"prefix":"10.1093","volume":"76","author":[{"given":"Aaron F","family":"Carlin","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California, San Diego School of Medicine , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex E","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego School of Medicine , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Chaillon","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego School of Medicine , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron F","family":"Garretson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego School of Medicine , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Diego School of Medicine , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Porrachia","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego School of Medicine , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AsherLev T","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Education, Health and Human Services, California State University San Marcos , San Marcos, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq M","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California, San Diego , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davey M","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego School of Medicine , La Jolla, California , USA"},{"name":"Veterans Affairs San Diego Healthcare System , San Diego, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"2023020817081329200_ciac496-B1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa2118542","article-title":"EPIC-HR Investigators. Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19","volume":"386","author":"Hammond","year":"2022","journal-title":"N Engl J Med"},{"key":"2023020817081329200_ciac496-B2","article-title":"Rapid relapse of symptomatic Omicron SARS-CoV-2 infection following early suppression with nirmatrelvir\/ritonavir","author":"Charness"},{"key":"2023020817081329200_ciac496-B3","doi-asserted-by":"crossref","first-page":"veab064","DOI":"10.1093\/ve\/veab064","article-title":"Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool","volume":"7","author":"O\u2019Toole","year":"2021","journal-title":"Virus Evol"},{"key":"2023020817081329200_ciac496-B4","year":"2021"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciac496\/44635160\/ciac496.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/3\/e530\/49125142\/ciac496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/3\/e530\/49125142\/ciac496.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T17:44:04Z","timestamp":1675878244000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/76\/3\/e530\/6611663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":4,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,7,8]]},"published-print":{"date-parts":[[2023,2,8]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciac496","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,7,8]]}}}