{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:03:56Z","timestamp":1793052236592,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Russian Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cholangiocarcinoma (CCA), a fatal bile duct cancer, has a high incidence in Western Siberia, Russian Federation. In addition, Opisthorchis felineus, a bile duct\u2013dwelling trematode liver fluke is highly endemic. Closely related species have been shown to be cancerogenic agents in Asia. We therefore examined the association between O felineus infection and CCA in Western Siberia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a hospital-based, individually matched case-control study between January 2017 and August 2020 in Tomsk Oblast and Khanty-Mansiysk Autonomous Okrug, Yugra, Russian Federation. Histologically confirmed CCA patients (cases) were compared with matched age, sex, and place of residence hospital controls. The examination of study participants included the diagnosis of current and past O felineus infection, abdominal ultrasonographical assessment, physical examination, and interview on exposures to potential risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 40 patients with CCA and 160 controls. Exposures to O felineus infection was strongly associated with CCA (odds ratio [OR], 3.9; 95% confidence interval [CI], 1.4\u201310.8; P = .008). Also, cases reported more often that they were currently or in the past were infected by O felineus compared with controls (OR, 4.03; 95% CI, 1.7\u20139.5; P = .001). Furthermore, cases reported river fish consumption and fishing habits significantly more often than controls (OR, 5.5; 95% CI, 1.5\u201319.8; P = .009 and OR, 3.3; 95% CI, 1.4\u20137.7; P = .005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The study results revealed a strong significantly increased risk for CCA development in O felineus\u2013infected individuals. Elaboration of the guidelines on screening programs for early CCA diagnosis, prevention, and treatment is socially important in endemic regions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac497","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T12:35:27Z","timestamp":1655728527000},"page":"e1392-e1398","source":"Crossref","is-referenced-by-count":31,"title":["<i>Opisthorchis Felineus<\/i> Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study"],"prefix":"10.1093","volume":"76","author":[{"given":"Olga S","family":"Fedorova","sequence":"first","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation , Tomsk , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-8323","authenticated-orcid":false,"given":"Anna E","family":"Kovshirina","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation , Tomsk , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia V","family":"Kovshirina","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation , Tomsk , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hattendorf","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute , Allschwil , Switzerland"},{"name":"University of Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V","family":"Onishchenko","sequence":"additional","affiliation":[{"name":"Surgut State University , Surgut , Russian Federation"},{"name":"Surgut Regional Clinical Hospital 14 , Surgut , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila L","family":"Katanakhova","sequence":"additional","affiliation":[{"name":"Surgut State University , Surgut , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav S","family":"Taslicki","sequence":"additional","affiliation":[{"name":"Surgut Regional Clinical Hospital 14 , Surgut , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey V","family":"Chizhikov","sequence":"additional","affiliation":[{"name":"Khanty-Mansiysk Medical Academy 40 , Khanty-Mansiysk , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya A","family":"Tataurov","sequence":"additional","affiliation":[{"name":"Regional Clinical Hospital 40 , Khanty-Mansiysk , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V","family":"Vtorushin","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation , Tomsk , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banchob","family":"Sripa","sequence":"additional","affiliation":[{"name":"Khon Kaen University , Khon Kaen , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila M","family":"Ogorodova","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation , Tomsk , Russian 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