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We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.<\/jats:p>","DOI":"10.1093\/cid\/ciac514","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T15:31:14Z","timestamp":1656516674000},"page":"531-534","source":"Crossref","is-referenced-by-count":6,"title":["Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus\/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0991-0011","authenticated-orcid":false,"given":"Maura","family":"Manion","sequence":"first","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroditi","family":"Boulougoura","sequence":"additional","affiliation":[{"name":"National 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