{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:33:29Z","timestamp":1788287609117,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondation J\u00e9r\u00f4me Lejeune"},{"DOI":"10.13039\/501100001673","name":"J\u00e9r\u00f4me Lejeune Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondo de Investigaci\u1f79n Sanitarias del Instituto de Salud Carlos III cofunded","award":["PI22\/01542"],"award-info":[{"award-number":["PI22\/01542"]}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune dysregulation in individuals with Down syndrome (DS) leads to an increased risk for hospitalization and death due to coronavirus disease 2019 (COVID-19) and may impair the generation of protective immunity after vaccine administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The cellular and humoral responses of 55 individuals with DS who received a complete SARS-CoV-2 vaccination regime at 1 to 3 (visit [V 1]) and 6 (V2) months were characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SARS-CoV-2\u2013reactive CD4+ and CD8+ T lymphocytes with a predominant Th1 phenotype were observed at V1 and increased at V2. Likewise, an increase in SARS-CoV-2\u2013specific circulating Tfh (cTfh) cells and CD8+ CXCR5+ PD-1hi lymphocytes was already observed at V1 after vaccine administration. Specific immunoglobulin G (IgG) antibodies against SARS-CoV-2 S protein were detected in 96% and 98% of subjects at V1 and V2, respectively, although IgG titers decreased significantly between both time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings show that DS individuals develop an effective immune response to usual regimes of SARS-CoV-2 vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciac590","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T06:28:51Z","timestamp":1658557731000},"page":"e155-e162","source":"Crossref","is-referenced-by-count":9,"title":["Development of an Effective Immune Response in Adults With Down Syndrome After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination"],"prefix":"10.1093","volume":"76","author":[{"given":"Laura","family":"Esparcia-Pinedo","sequence":"first","affiliation":[{"name":"Immunology Department, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"Yarci-Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Mateo-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n de Investigaci\u00f3n Biom\u00e9dica del Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Ropero","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"G\u00f3mez-Caba\u00f1as","sequence":"additional","affiliation":[{"name":"Biobanco, Fundaci\u00f3n de Investigaci\u00f3n del Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Lancho-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Biobanco, Fundaci\u00f3n de Investigaci\u00f3n del Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Almendro-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Mart\u00edn-Gayo","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]},{"name":"Department of Medicine, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Paz-Artal","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Sanchez-Madrid","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]},{"name":"Department of Medicine, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Guti\u00e9rrez-Cobos","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , 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