{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:57:21Z","timestamp":1768449441445,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Malaria National Reference Centre"},{"name":"French Public Health Agency","award":["0058"],"award-info":[{"award-number":["0058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The impact of chemoprophylaxis targeting Plasmodium falciparum on Plasmodium vivax and Plasmodium ovale, which may remain quiescent as hypnozoites in the liver, is debated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a nested case-control analysis of the outcomes of P. vivax and P. ovale infections in imported malaria cases in France among civilian travelers from 1 January 2006, to 31 December 2017. Using adjusted logistic regression, we assessed the effect of chemoprophylaxis on the incubation period, time from symptoms to diagnosis, management, blood results, symptoms, and hospitalization duration. We analyzed the effect of blood-stage drugs (doxycycline, mefloquine, chloroquine, chloroquine-proguanil) or atovaquone-proguanil on the incubation period. We used a counterfactual approach to ascertain the causal effect of chemoprophylaxis on postinfection characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 247 P. vivax\u2013 and 615 P. ovale\u2013infected travelers, 30% and 47%, respectively, used chemoprophylaxis, and 7 (3%) and 8 (1%) were severe cases. Chemoprophylaxis users had a greater risk of presenting symptoms &amp;gt;2 months after returning for both species (P. vivax odds ratio [OR], 2.91 [95% confidence interval {CI}, 1.22\u20136.95], P = .02; P. ovale OR, 2.28 [95% CI, 1.47\u20133.53], P &amp;lt; .001). Using drugs only acting on the blood stage was associated with delayed symptom onset after 60 days, while using atovaquone-proguanil was not.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Civilian travelers infected with P. vivax or P. ovale reporting chemoprophylaxis use, especially of blood-stage agents, had a greater risk of delayed onset of illness. The impact of chemoprophylaxis on the outcomes of infection with relapse-causing species calls for new chemoprophylaxis acting against erythrocytic and liver stages.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac641","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T14:46:52Z","timestamp":1660402012000},"page":"e884-e893","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Chemoprophylaxis on <i>Plasmodium vivax<\/i> and <i>Plasmodium ovale<\/i> Infection Among Civilian Travelers: A Nested Case-Control Study With a Counterfactual Approach on 862 Patients"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-4564","authenticated-orcid":false,"given":"Ma\u00eblle","family":"Le Goff","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale, Service des maladies infectieuses et tropicales, Centre Hospitalier R\u00e9gional Universitaire La Cavale Blanche , Brest , France"},{"name":"Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Inserm , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Kendjo","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Inserm , Paris , France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Thellier","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Inserm , Paris , France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme , Paris , France"},{"name":"Sorbonne Universit\u00e9, Service de parasitologie, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique - H\u00f4pitaux de Paris , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Piarroux","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Inserm , Paris , France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme , Paris , France"},{"name":"Sorbonne Universit\u00e9, Service de parasitologie, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique - H\u00f4pitaux de Paris , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Boelle","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Inserm , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-5464","authenticated-orcid":false,"given":"St\u00e9phane","family":"Jaur\u00e9guiberry","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme , Paris , France"},{"name":"Universit\u00e9 de Paris Saclay, Service des maladies infectieuses et tropicales, H\u00f4pital Bic\u00eatre, Assistance Publique - H\u00f4pitaux de Paris , Le Kremlin Bic\u00eatre , France"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine des Voyages , Paris , France"},{"name":"Universit\u00e9 de Paris Saclay, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations, Inserm , Villejuif , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the French National Reference Centre for Imported Malaria Study 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