{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:07:08Z","timestamp":1791180428308,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR002346"],"award-info":[{"award-number":["KL2TR002346"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DE029514"],"award-info":[{"award-number":["K23DE029514"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSK-3_190977\/1"],"award-info":[{"award-number":["CRSK-3_190977\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Staphylococcus aureus represents the leading cause of complicated bloodstream infections among persons who inject drugs (PWID). Standard of care (SOC) intravenous (IV) antibiotics result in high rates of treatment success but are not feasible for some PWID. Transition to oral antibiotics may represent an alternative treatment option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated all adult patients with a history of injection drug use hospitalized from January 2016 through December 2021 with complicated S. aureus bloodstream infections, including infective endocarditis, epidural abscess, vertebral osteomyelitis, and septic arthritis. Patients were compared by antibiotic treatment (standard of care intravenous [SOC IV] antibiotics, incomplete IV therapy, or transition from initial IV to partial oral) using the primary composite endpoint of death or readmission from microbiologic failure within 90 days of discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients who received oral antibiotics after an incomplete IV antibiotic course were significantly less likely to experience microbiologic failure or death than patients discharged without oral antibiotics (P &amp;lt; .001). There was no significant difference in microbiologic failure rates when comparing patients who were discharged on partial oral antibiotics after receiving at least 10 days of IV antibiotics with SOC regimens (P &amp;gt; .9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Discharge of PWID with partially treated complicated S. aureus bacteremias without oral antibiotics results in high rates of morbidity and should be avoided. For PWID hospitalized with complicated S. aureus bacteremias who have received at least 10 days of effective IV antibiotic therapy after clearance of bacteremia, transition to oral antibiotics with outpatient support represents a potential alternative if the patient does not desire SOC IV antibiotic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciac714","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T02:28:35Z","timestamp":1662085715000},"page":"487-496","source":"Crossref","is-referenced-by-count":54,"title":["Outcomes of Partial Oral Antibiotic Treatment for Complicated\n                    <i>Staphylococcus aureus<\/i>\n                    Bacteremia in People Who Inject Drugs"],"prefix":"10.1093","volume":"76","author":[{"given":"John A","family":"Wildenthal","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"},{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"},{"name":"Department of Computational and Systems Biology, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, Inselspital, University of Bern , Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1993-0764","authenticated-orcid":false,"given":"Sena","family":"Sayood","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanial S","family":"Nolan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolo L","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Marschall","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Durkin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5317-443X","authenticated-orcid":false,"given":"Laura R","family":"Marks","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St. Louis School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"2023053119095716600_ciac714-B1","doi-asserted-by":"crossref","first-page":"S458","DOI":"10.1093\/infdis\/jiaa129","article-title":"Not just endocarditis: hospitalizations for selected invasive infections among persons with opioid and stimulant use diagnoses-North Carolina, 2010","volume":"222","author":"Sredl","year":"2020","journal-title":"J Infect Dis"},{"key":"2023053119095716600_ciac714-B2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.15585\/mmwr.mm6722a2","article-title":"Invasive methicillin-resistant Staphylococcus aureus infections among persons who inject drugs - 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