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progression among people with human immunodeficiency virus (PWH) is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We defined eGFR stages using the original race-adjusted Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFRcr equation and the new race-free CKD-EPI eGFRcr equation. We then estimated 5-year probabilities of transitioning from baseline kidney function to more advanced eGFR stages and examined the association of race (black vs white) with rates of CKD progression using Markov models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>With the race-adjusted eGFRcr equation, black participants (n = 31 298) had a lower risk of progressing from eGFR stage 1 to 2 (hazard ratio [HR], 0.77; 95% confidence interval [CI], .73\u2013.82), an equal risk of progressing from stage 2 to 3 (1.00; .92\u2013.07) and a 3-fold risk of progressing from stage 3 to 4 or 5 (3.06; 2.60\u20133.62), compared with white participants (n = 27 542). When we used the race-free eGFRcr equation, 16% of black participants were reclassified into a more severe eGFR stage at baseline. The reclassified black individuals had a higher prevalence of CKD risk factors than black PWH who were not reclassified. With the race-free eGFRcr equation, black participants had a higher risk of disease progression across all eGFR stages than white participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The original eGFRcr equation systematically masked a subgroup of black PWH who are at high-risk of CKD progression. The new race-free eGFRcr equation unmasks these individuals and may allow for earlier detection and management of CKD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac731","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T07:29:19Z","timestamp":1662535759000},"page":"461-468","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Adopting the New Race-Free 2021 Chronic Kidney Disease Epidemiology Collaboration Estimated Glomerular Filtration Rate Creatinine Equation on Racial Differences in Kidney Disease Progression Among People With Human Immunodeficiency Virus: An Observational Study"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-9658","authenticated-orcid":false,"given":"Anthony N","family":"Muiru","sequence":"first","affiliation":[{"name":"Kidney Health Research Collaborative, Department of Medicine, University of California , San Francisco, California , 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A","family":"Horberg","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Mid-Atlantic Permanente Research Institute , Rockville, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9322-1395","authenticated-orcid":false,"given":"Michael J","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California , Oakland, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina B","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel M","family":"Mayor","sequence":"additional","affiliation":[{"name":"Retrovirus Research Center, Internal Medicine Department, Universidad Central del Caribe, School of Medicine, Bayamon, Puerto Rico , 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C","family":"Marconi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia , USA"},{"name":"Department of Global Health, Rollins School of Public Health, Emory University , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-6942","authenticated-orcid":false,"given":"John R","family":"Koethe","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison G","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Colorado , Anschutz Medical Campus, Aurora, Colorado , USA"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , 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