{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:08:02Z","timestamp":1740128882589,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"crossref","award":["IN-ES-540-6089"],"award-info":[{"award-number":["IN-ES-540-6089"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hospital Cl\u00ednic de Barcelona-Fundaci\u00f3 Cl\u00ednic per a la Recerca Biom\u00e8dica"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is no reliable microbiological marker to guide the indication and the response to antiviral treatment in patients with coronavirus disease 2019 (COVID-19). We aimed to evaluate the dynamics of subgenomic RNA (sgRNA) in patients with COVID-19 before and after receiving treatment with remdesivir.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included consecutive patients admitted for COVID-19 who received remdesivir according to our institutional protocol and accepted to participate in the study. A nasopharyngeal swab for quantitative reverse transcriptase\u2013polymerase chain reaction (qRT-PCR) was collected at baseline and after 3 and 5 days of treatment with remdesivir. Genomic and sgRNA were analyzed in those samples and main comorbidities and evolution were collected for the analyses. The main outcomes were early discharge (\u226410 days) and 30-day mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 117 patients were included in the study, of whom 24 had a negative sgRNA at baseline, with 62.5% (15\/24) receiving early discharge (\u226410 days) and no deaths in this group. From the 93 remaining patients, 62 had a negative sgRNA at day 5 with 37\/62 (59.6%) with early discharge and a mortality rate of 4.8% (3\/62). In the subgroup of 31 patients with positive sgRNA after 5 days of remdesivir, the early discharge rate was 29% (9\/31) and the mortality rate was 16.1% (5\/31). In multivariable analyses, the variables associated with early discharge were negative sgRNA at day 3 and not needing treatment with corticosteroids or intensive care unit admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Qualitative sgRNA could help in monitoring the virological response in patients who receive remdesivir. Further studies are needed to confirm these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac760","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T04:51:48Z","timestamp":1662699108000},"page":"32-38","source":"Crossref","is-referenced-by-count":3,"title":["Qualitative Subgenomic RNA to Monitor the Response to Remdesivir in Hospitalized Patients With Coronavirus Disease 2019: Impact on the Length of Hospital Stay and Mortality"],"prefix":"10.1093","volume":"76","author":[{"given":"Rodrigo","family":"Alonso-Navarro","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9031-0787","authenticated-orcid":false,"given":"Genoveva","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Garcia-Pouton","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Tuset","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hospital Clinic, IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bodro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Morata","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-0217","authenticated-orcid":false,"given":"Pedro","family":"Puerta-Alcalde","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafne","family":"Soria","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Clinic of Barcelona, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Aldea","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Hospital Cl\u00ednic of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Mensa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"},{"name":"CIBERINF , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"del Rio","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of 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Angeles","family":"Marcos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Clinic of Barcelona, University of Barcelona , Barcelona , Spain"},{"name":"Institute for Global Health (ISGlobal) , Barcelona , Spain"},{"name":"CIBERINF , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-0811","authenticated-orcid":false,"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona , Barcelona , Spain"},{"name":"CIBERINF , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"2023010809023800700_ciac760-B1","doi-asserted-by":"crossref","first-page":"105252","DOI":"10.1016\/j.antiviral.2022.105252","article-title":"Remdesivir, molnupiravir and nirmatrelvir remain active against 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