{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:03:28Z","timestamp":1776924208489,"version":"3.51.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cholera remains a public health threat for low- and middle-income countries, particularly in Asia and Africa. Shanchol\u2122, an inactivated oral cholera vaccine (OCV) is currently in use globally. OCV and oral poliovirus vaccines (OPV) could be administered concomitantly, but the immunogenicity and safety of coadministration among children aged 1\u20133 years is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We undertook an open-label, randomized, controlled, inequality trial in Dhaka city, Bangladesh. Healthy children aged 1\u20133 years were randomly assigned to 1 of 3 groups: bivalent OPV (bOPV)-alone, OCV-alone, or combined bOPV + OCV and received vaccines on the day of enrollment and 28 days later. Blood samples were collected on the day of enrollment, day 28, and day 56. Serum poliovirus neutralizing antibodies and vibriocidal antibodies against Vibrio cholerae O1 were assessed using microneutralization assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 579 children aged 1\u20123 years were recruited, 193 children per group. More than 90% of the children completed visits at day 56. Few adverse events following immunization were recorded and were equivalent among study arms. On day 28, 60% (90% confidence interval: 53%\u201367%) and 54% (46%\u201361%) of participants with co-administration of bOPV + OCV responded to polioviruses type 1 and 3, respectively, compared to 55% (47%\u201362%) and 46% (38%\u201353%) in the bOPV-only group. Additionally, &amp;gt;50% of participants showed a \u22654-fold increase in vibriocidal antibody titer responses on day 28, comparable to the responses observed in OCV-only arm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Co-administration of bOPV and OCV is safe and effective in children aged 1\u20133 years and can be cost-beneficial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>ClinicalTrials.gov (NCT03581734).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac782","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T16:49:40Z","timestamp":1663865380000},"page":"263-270","source":"Crossref","is-referenced-by-count":4,"title":["Co-administration of Oral Cholera Vaccine With Oral Polio Vaccine Among Bangladeshi Young Children: A Randomized Controlled Open Label Trial to Assess Interference"],"prefix":"10.1093","volume":"76","author":[{"given":"Md Taufiqul","family":"Islam","sequence":"first","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"},{"name":"Infectious Diseases and Immunology, Menzies Health Institute Queensland and School of Pharmacy and Medical Science, Griffith University , Gold Coast , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kashmira","family":"Date","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraful Islam","family":"Khan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taufiqur Rahman","family":"Bhuiyan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahid Hasan","family":"Khan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamim","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motaher","family":"Hossain","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema","family":"Khaton","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Zaman","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel A J","family":"McMillan","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunology, Menzies Health Institute Queensland and School of Pharmacy and Medical Science, Griffith University , Gold Coast , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijeet","family":"Anand","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"An","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C","family":"Weldon","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and 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