{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:56:36Z","timestamp":1789088196023,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HVTN702"],"award-info":[{"award-number":["HVTN702"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201300033C"],"award-info":[{"award-number":["HHSN272201300033C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201600012C"],"award-info":[{"award-number":["HHSN272201600012C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068635"],"award-info":[{"award-number":["UM1AI068635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1017604"],"award-info":[{"award-number":["OPP1017604"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"US Public Health Service","doi-asserted-by":"publisher","award":["UM1 AI068614"],"award-info":[{"award-number":["UM1 AI068614"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"US Public Health Service","doi-asserted-by":"publisher","award":["UM1 AI068635"],"award-info":[{"award-number":["UM1 AI068635"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"US Public Health Service","doi-asserted-by":"publisher","award":["UM1 AI068618"],"award-info":[{"award-number":["UM1 AI068618"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HEARD scholarship"},{"DOI":"10.13039\/100004441","name":"Swedish International Development Cooperation Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004441","id-type":"DOI","asserted-by":"crossref"}]},{"name":"HIV Vaccines Trial Network's"},{"name":"Research and Mentorship Program"},{"name":"Wellcome Trust PhD Programme Primary Care Clinicians","award":["216421\/Z\/19\/Z"],"award-info":[{"award-number":["216421\/Z\/19\/Z"]}]},{"DOI":"10.13039\/100005895","name":"Fred Hutchinson Cancer Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alternative approaches to syndromic management are needed to reduce rates of sexually transmitted infections (STIs) in resource-limited settings. We investigated the impact of point-of-care (POC) versus central laboratory\u2013based testing on STI treatment initiation and STI adverse event (STI-AE) reporting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used Kaplan-Meier and Cox regression models to compare times to treatment initiation and STI-AE reporting among HVTN702 trial participants in South Africa. Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) were diagnosed POC at eThekwini clinic and in a central laboratory at Verulam\/Isipingo clinics. All clinics used POC assays for Trichomonas vaginalis (TV) testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 959 women (median age, 23 [interquartile range, 21\u201326] years), median days (95% confidence interval [95%CI]) to NG\/CT treatment initiation and NG\/CT-AE reporting were 0.20 (.16\u2013.25) and 0.24 (.19\u2013.27) at eThekwini versus 14.22 (14.12\u201315.09) and 15.12 (13.22\u201321.24) at Verulam\/Isipingo (all P &amp;lt; .001). Median days (95%CI) to TV treatment initiation and TV-AE reporting were 0.17 (.12\u2013.27) and 0.25 (.20\u2013.99) at eThekwini versus 0.18 (.15\u2013.2) and 0.24 (.15\u2013.99) at Verulam\/Isipingo (all P &amp;gt; .05). Cox regression analysis revealed that NG\/CT treatment initiation (adjusted hazard ratio [aHR], 39.62 [95%CI, 15.13\u2013103.74]) and NG\/CT-AE reporting (aHR, 3.38 [95%CI, 2.23\u20135.13]) occurred faster at eThekwini versus Verulam\/Isipingo, while times to TV treatment initiation (aHR, 0.93 [95%CI, .59\u20131.48]) and TV-AE reporting (aHR, 1.38 [95%CI, .86\u20132.21]) were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>POC testing led to prompt STI management with potential therapeutic and prevention benefits, highlighting its utility as a diagnostic tool in resource-limited settings.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciac824","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T09:19:13Z","timestamp":1665998353000},"page":"881-889","source":"Crossref","is-referenced-by-count":16,"title":["Impact of Point-of-Care Testing on the Management of Sexually Transmitted Infections in South Africa: Evidence from the HVTN702 Human Immunodeficiency Virus Vaccine Trial"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-2315","authenticated-orcid":false,"given":"Kwabena","family":"Asare","sequence":"first","affiliation":[{"name":"Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal , Durban , South Africa"},{"name":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal , Durban , South Africa"},{"name":"Health Economics and HIV and AIDS Research Division, University of KwaZulu-Natal , Durban , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsion","family":"Andine","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Howard University , Washington, District of Columbia , 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