{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:31:49Z","timestamp":1787938309666,"version":"build-2784847793"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"CEREDIH, Association IRIS, CSL Behring, LFB, Octapharma, Vitalaire, and The Binding Site"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary immunodeficiencies (PIDs) in adults are mainly revealed by recurrent and\/or severe bacterial infections. The objective of this study was to evaluate a systematic research strategy of PIDs in adults with unexplained bacterial infections, with a special focus on specific polysaccharide antibody deficiency (SPAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective multicenter study, inclusion criteria were recurrent benign upper and lower respiratory tract infections (RTIs) for at least two years (group 1), at least one upper or lower RTI requiring hospitalization (group 2), and\/or at least one invasive infection documented with encapsulated bacteria (group 3). Main exclusion criteria were all local and general conditions that could explain infections. If no PID diagnosis was made, response to polysaccharide antigens was assessed using a pneumococcal polysaccharide vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From March 2015 to March 2020, 118 patients were included (37 males, median age of 41 years): 73, 17, and 28 in groups 1, 2, and 3, respectively. Forty-seven PIDs were diagnosed, giving an estimated frequency of 39.8% (95% confidence interval [CI] [30.4, 48.8]). SPAD was the most frequent diagnosis by far (n = 37\/47, 78.7%), and was made in 23, 5, and 9 patients from groups 1 to 3, respectively. All SPAD patients received conjugate vaccines and, according to their infectious history, were on surveillance or treated with preventive antibiotics (n = 6) and\/or with immunoglobulins replacement therapy (n = 10), the latter being dramatically efficient in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Considering its high prevalence among adults with unexplained recurrent and\/or severe bacterial infections, SPAD should be screened in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trials Registration<\/jats:title><jats:p>NCT02972281.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciac842","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T08:03:22Z","timestamp":1666771402000},"page":"800-808","source":"Crossref","is-referenced-by-count":6,"title":["High Frequency of Specific Polysaccharide Antibody Deficiency in Adults With Unexplained, Recurrent and\/or Severe Infections With Encapsulated Bacteria"],"prefix":"10.1093","volume":"76","author":[{"given":"Sarah","family":"Stabler","sequence":"first","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et immunologie clinique, CHU Lille , Lille , France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO) , Lille , France"},{"name":"D\u00e9partement de maladies infectieuses et tropicales, CHU Lille , Lille , France"},{"name":"Universit\u00e9 Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019\u2014UMR 9017\u2014CIIL\u2014Center for Infection and Immunity of Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lamblin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie, H\u00f4pital priv\u00e9 La Louvi\u00e8re , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha","family":"Gaillard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie, Clinique Tessier , Valenciennes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Just","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie, CH Roubaix , Roubaix , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Mihailescu","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie, CH Montreuil , Montreuil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Viget","sequence":"additional","affiliation":[{"name":"D\u00e9partement de maladies infectieuses et tropicales, CH Tourcoing , Tourcoing , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierno","family":"Sy Ndiaye","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne, CH d\u2019Armenti\u00e8res , Armenti\u00e8res , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Dzeing Ella","sequence":"additional","affiliation":[{"name":"D\u00e9partement de maladies infectieuses et tropicales, m\u00e9decine interne et polyvalente, CH Denain , Denain , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Brunin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de r\u00e9animation, CH Boulogne , Boulogne Sur Mer , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Weyrich","sequence":"additional","affiliation":[{"name":"D\u00e9partement de maladies infectieuses, Groupement Hospitalier de l\u2019Institut Catholique de Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Prevotat","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Chenivesse","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Le Rouzic","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019\u2014UMR 9017\u2014CIIL\u2014Center for Infection and Immunity of Lille , Lille , France"},{"name":"D\u00e9partement de pneumologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Mortuaire","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019oto-rhino-laryngologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Vuotto","sequence":"additional","affiliation":[{"name":"D\u00e9partement de maladies infectieuses et tropicales, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Faure","sequence":"additional","affiliation":[{"name":"D\u00e9partement de maladies infectieuses et tropicales, CHU Lille , Lille , France"},{"name":"Universit\u00e9 Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019\u2014UMR 9017\u2014CIIL\u2014Center for Infection and Immunity of Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Leurs","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et maladies infectieuses, CH Dunkerque , Dunkerque , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Wallet","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Loiez","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Titecat","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, CHU Lille , Lille , France"},{"name":"Universit\u00e9 de Lille, U1286 INFINITE, Institut de recherche translationnelle sur l'inflammation , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Le Guern","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019\u2014UMR 9017\u2014CIIL\u2014Center for Infection and Immunity of Lille , Lille , France"},{"name":"Laboratoire de Bact\u00e9riologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et immunologie clinique, CHU Lille , Lille , France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO) , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Sanges","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et immunologie clinique, CHU Lille , Lille , France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO) , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Etienne","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et immunologie clinique, CHU Lille , Lille , France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO) , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Terriou","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et immunologie clinique, CHU Lille , Lille , France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO) , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Launay","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et immunologie clinique, CHU Lille , Lille , France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO) , Lille , France"},{"name":"Universit\u00e9 de Lille, U1286 INFINITE, Institut de recherche translationnelle sur l'inflammation , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lopez","sequence":"additional","affiliation":[{"name":"Institut d\u2019Immunologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Bahuaud","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019immunologie, CHU Cochin\u2014H\u00f4tel Dieu\u2014Broca , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Batteux","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019immunologie, CHU Cochin\u2014H\u00f4tel Dieu\u2014Broca , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Dubucquoi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, U1286 INFINITE, Institut de recherche translationnelle sur l'inflammation , Lille , France"},{"name":"Institut d\u2019Immunologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Gesqui\u00e8re-Lasselin","sequence":"additional","affiliation":[{"name":"Institut d\u2019Immunologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labalette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, U1286 INFINITE, Institut de recherche translationnelle sur l'inflammation , Lille , France"},{"name":"Institut d\u2019Immunologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lef\u00e8vre","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne et immunologie clinique, CHU Lille , Lille , France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO) , Lille , France"},{"name":"Universit\u00e9 de Lille, U1286 INFINITE, Institut de recherche translationnelle sur l'inflammation , Lille , France"},{"name":"Institut d\u2019Immunologie, CHU Lille , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the DIPANOR network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10875-012-9751-7","article-title":"Primary immunodeficiency diseases worldwide: more common than generally thought","volume":"33","author":"Bousfiha","year":"2013","journal-title":"J Clin Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4065\/84.1.16","article-title":"Incidence and temporal trends of primary immunodeficiency: a population-based cohort study","volume":"84","author":"Joshi","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.clim.2010.02.021","article-title":"The French national registry of primary immunodeficiency diseases","volume":"135","author":"CEREDIH: The French PID study group","year":"2010","journal-title":"Clin Immunol Orlando Fla"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"e3548","DOI":"10.1097\/MD.0000000000003548","article-title":"Infections revealing complement deficiency in adults: a French nationwide study enrolling 41 patients","volume":"95","author":"Audemard-Verger","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","article-title":"Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency","volume":"27","author":"Quinti","year":"2007","journal-title":"J Clin Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/587669","article-title":"Infections in 252 patients with common variable immunodeficiency","volume":"46","author":"Oksenhendler","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1128\/CMR.00048-09","article-title":"Infections of people with complement deficiencies and patients who have undergone splenectomy","volume":"23","author":"Ram","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"2023030705143855100_"},{"key":"2023030705143855100_"},{"key":"2023030705143855100_"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"576.e1","DOI":"10.1016\/j.cmi.2017.02.005","article-title":"Diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection","volume":"23","author":"Sanges","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"2023030705143855100_","author":"ESID\u2014European Society for Immunodeficiencies"},{"key":"2023030705143855100_","first-page":"514","article-title":"Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides","volume":"10","author":"Wernette","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jaci.2015.04.049","article-title":"Practice parameter for the diagnosis and management of primary immunodeficiency","volume":"136","author":"Bonilla","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2012.07.002","article-title":"Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the basic and clinical immunology interest section of the American Academy of Allergy, Asthma & Immunology","volume":"130","author":"Orange","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.3389\/fimmu.2017.01862","article-title":"Value of the overall pneumococcal polysaccharide response in the diagnosis of primary humoral immunodeficiencies","volume":"8","author":"Lopez","year":"2017","journal-title":"Front Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.amjoto.2007.11.007","article-title":"Immunologic evaluation of patients with recurrent ear, nose, and throat infections","volume":"29","author":"Aghamohammadi","year":"2008","journal-title":"Am J Otolaryngol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/00365549709011838","article-title":"Immunoglobulin deficiencies and impaired immune response to polysaccharide antigens in adult patients with recurrent community-acquired pneumonia","volume":"29","author":"Ekdahl","year":"1997","journal-title":"Scand J Infect Dis"},{"key":"2023030705143855100_","first-page":"703","article-title":"Serum IgG subclasses in chronic and recurrent respiratory infections","volume":"58","author":"Stanley","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1086\/513763","article-title":"Impaired antibody response to pneumococcal capsular polysaccharides and phosphorylcholine in adult patients with a history of bacteremic pneumococcal infection","volume":"25","author":"Ekdahl","year":"1997","journal-title":"Clin Infect Dis"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijid.2013.10.020","article-title":"Immunoglobulin deficiency in patients with Streptococcus pneumoniae or Haemophilus influenzae invasive infections","volume":"19","author":"Martinot","year":"2014","journal-title":"Int J Infect Dis"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaip.2019.01.024","article-title":"Specific antibody deficiencies in clinical practice","volume":"7","author":"Sorensen","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10875-019-00691-8","article-title":"Defining polysaccharide antibody deficiency: measurement of anti-pneumococcal antibodies and anti-Salmonella typhi antibodies in a cohort of patients with recurrent infections","volume":"40","author":"Bucciol","year":"2020","journal-title":"J Clin Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.iac.2015.07.003","article-title":"Specific antibody deficiencies","volume":"35","author":"Wall","year":"2015","journal-title":"Immunol Allergy Clin North Am"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2500\/ajra.2011.25.3653","article-title":"Characterization of specific antibody deficiency in adults with medically refractory chronic rhinosinusitis","volume":"25","author":"Carr","year":"2011","journal-title":"Am J Rhinol Allergy"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaip.2016.11.033","article-title":"The clinical significance of Specific Antibody Deficiency (SAD) severity in Chronic Rhinosinusitis (CRS)","volume":"5","author":"Keswani","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jaip.2014.09.022","article-title":"Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency","volume":"3","author":"Kashani","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1183\/09031936.05.00073204","article-title":"Impaired pneumococcal antibody response in bronchiectasis of unknown aetiology","volume":"25","author":"van Kessel","year":"2005","journal-title":"Eur Respir J"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/cid\/cix284","article-title":"Specific polysaccharide antibody deficiency revealed by severe bacterial infections in adulthood: a report on 11 cases","volume":"65","author":"Lopez","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/cid\/ciu646","article-title":"Prevention of infections during primary immunodeficiency","volume":"59","author":"Aguilar","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2023030705143855100_"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3389\/fimmu.2019.00986","article-title":"A critical view of specific antibody deficiencies","volume":"10","author":"Sorensen","year":"2019","journal-title":"Front Immunol"},{"key":"2023030705143855100_","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s10875-019-00716-2","article-title":"Prophylactic antibiotics versus immunoglobulin replacement in specific antibody deficiency","volume":"40","author":"Hajjar","year":"2020","journal-title":"J Clin Immunol"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciac842\/47762387\/ciac842.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/5\/800\/49424696\/ciac842.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/5\/800\/49424696\/ciac842.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:02:31Z","timestamp":1678406551000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/76\/5\/800\/6773444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10,26]]},"published-print":{"date-parts":[[2023,3,4]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciac842","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,10,26]]}}}