{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:48:31Z","timestamp":1775641711839,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Leadership Investigator"},{"name":"Australian Government Research Training Program"},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We compared the rapid plasma reagin (RPR) titer on the day of initial presentation with that on the day of syphilis treatment to inform clinical practice as to whether a repeated RPR test should be recommended.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a retrospective study between 1 March 2011 and 31 December 2020 at the Melbourne Sexual Health Centre in Australia among individuals who underwent syphilis serology on the day of initial presentation and the day of treatment, if the latter were within 14 days after initial presentation. We calculated the percentage of individuals with a \u22654-fold change in RPR titer, stratified by the time between initial presentation and treatment and by syphilis stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 766 included syphilis cases, the median duration between initial presentation and treatment was 6 days (interquartile range, 5\u20137 days). Of these cases, 14.8% (n = 113) had a \u22654-fold increase or decrease during this interval. The number of cases with a \u22654-fold increase or decrease in RPR titer increased with increasing time between initial presentation and treatment, from 5.7% (n = 6) 1\u20133 days after initial presentation to 26.2% (n = 27) at 10\u201314 days (Ptrend &amp;lt; .001). There was no significant difference in the number of cases with a \u22654-fold increase or decrease in RPR titer between syphilis stages (P = .66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support the recommendation of repeating the RPR titer if the day of initial presentation and the day of treatment are different, even when treatment is within a few days after initial presentation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciac843","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:41:25Z","timestamp":1666701685000},"page":"795-799","source":"Crossref","is-referenced-by-count":9,"title":["Changes in the Syphilis Rapid Plasma Reagin Titer Between Diagnosis and Treatment"],"prefix":"10.1093","volume":"76","author":[{"given":"Katrina","family":"Pandey","sequence":"first","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health , Melbourne, Victoria , Australia"},{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K","family":"Fairley","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health , Melbourne, Victoria , Australia"},{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Y","family":"Chen","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health , Melbourne, Victoria , Australia"},{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne, Victoria , Australia"},{"name":"Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity , Melbourne, Victoria , Australia"},{"name":"Walter and Eliza Hall Institute , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona S","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health , Melbourne, Victoria , Australia"},{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria , Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason J","family":"Ong","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health , Melbourne, Victoria , Australia"},{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ei T","family":"Aung","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health , Melbourne, Victoria , Australia"},{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-0657","authenticated-orcid":false,"given":"Eric P F","family":"Chow","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health , Melbourne, Victoria , Australia"},{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria , Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1016\/S2352-3018(19)30043-8","article-title":"Epidemiology and prevention of sexually transmitted infections in men who have sex with men at risk of HIV","volume":"6","author":"Chow","year":"2019","journal-title":"Lancet HIV"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/sextrans-2017-053273","article-title":"100 Years of STIs in the UK: a review of national surveillance data","volume":"94","author":"Mohammed","year":"2018","journal-title":"Sex Transm Infect"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"851635","DOI":"10.3389\/fmed.2022.851635","article-title":"Incidence trends of five common sexually transmitted infections excluding HIV from 1990 to 2019 at the global, regional, and national levels: results from the Global Burden of Disease Study 2019","volume":"9","author":"Fu","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2023030705145204400_","author":"Kirby Institute"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(21)00221-7","article-title":"Prevalence of syphilis among men who have sex with men: a global systematic review and meta-analysis from 2000\u201320","volume":"9","author":"Tsuboi","year":"2021","journal-title":"Lancet Glob Health"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1097\/OLQ.0000000000001438","article-title":"Spatial and temporal epidemiology of infectious syphilis in Victoria, Australia, 2015\u20132018","volume":"48","author":"Aung","year":"2021","journal-title":"Sex Transm Dis"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1177\/0956462415624059","article-title":"UK national guidelines on the management of syphilis 2015","volume":"27","author":"Kingston","year":"2016","journal-title":"Int J STD AIDS"},{"key":"2023030705145204400_","author":"Australian Sexual Health Alliance"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"2023030705145204400_"},{"key":"2023030705145204400_","author":"Communicable Diseases Network Australia (CDNA)"},{"key":"2023030705145204400_","author":"Australian Government Department of Health and Aged Care"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/OLQ.0b013e3182536574","article-title":"Rapid plasma reagin titer variation in the 2 weeks after syphilis therapy","volume":"39","author":"Holman","year":"2012","journal-title":"Sex Transm Dis"},{"key":"2023030705145204400_"},{"key":"2023030705145204400_","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijid.2022.03.014","article-title":"Platelet indices are the promising biomarkers in monitoring disease activities in patients with syphilis","volume":"118","author":"Jiang","year":"2022","journal-title":"Int J Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciac843\/48356090\/ciac843.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/5\/795\/49424733\/ciac843.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/76\/5\/795\/49424733\/ciac843.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T22:52:20Z","timestamp":1678402340000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/76\/5\/795\/6773678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10,26]]},"published-print":{"date-parts":[[2023,3,4]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciac843","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,10,26]]}}}