{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:34:03Z","timestamp":1782189243531,"version":"3.54.5"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107345"],"award-info":[{"award-number":["R01MH107345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30MH62512"],"award-info":[{"award-number":["P30MH62512"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01 MH22005"],"award-info":[{"award-number":["N01 MH22005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Neurofilament light (NFL) chain concentrations, reflecting axonal damage, are seen in several polyneuropathies but have not been studied in human immunodeficiency virus (HIV) distal sensory polyneuropathy (DSP). We evaluated NFL in cerebrospinal fluid (CSF) and plasma in relation to DSP in people with HIV (PWH) from 2 independent cohorts and in people without HIV (PWoH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cohort 1 consisted of PWH from the CHARTER Study. Cohort 2 consisted of PWH and PWoH from the HIV Neurobehavioral Research Center (HNRC). We evaluated DSP signs and symptoms in both cohorts. Immunoassays measured NFL in CSF for all and for plasma as well in Cohort 2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cohort 1 consisted of 111 PWH, mean \u00b1 SD age 56.8 \u00b1 8.32 years, 15.3% female, 38.7% Black, 49.6% White, current CD4+ T-cells (median, interquartile range [IQR]) 532\/\u00b5L (295, 785), 83.5% with plasma HIV RNA \u226450 copies\/mL. Cohort 2 consisted of 233 PWH of similar demographics to PWH in Cohort 1 but also 51 PWoH, together age 58.4 \u00b1 6.68 years, 41.2% female, 18.0% Black, Hispanic, non-Hispanic White 52.0%, 6.00% White. In both cohorts of PWH, CSF and plasma NFL were significantly higher in both PWH with DSP signs. Findings were similar, albeit not significant, for PWoH. The observed relationships were not explained by confounds.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both plasma and CSF NFL were elevated in PWH and PWoH with DSP. The convergence of our findings with others demonstrates that NFL is a reliable biomarker reflecting peripheral nerve injury. Biomarkers such as NFL might provide, validate, and optimize clinical trials of neuroregenerative strategies in HIV DSP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac851","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T07:37:21Z","timestamp":1667201841000},"page":"1103-1109","source":"Crossref","is-referenced-by-count":4,"title":["Higher Levels of Cerebrospinal Fluid and Plasma Neurofilament Light in Human Immunodeficiency Virus-Associated Distal Sensory Polyneuropathy"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-752X","authenticated-orcid":false,"given":"Ronald J","family":"Ellis","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego , San Diego, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Chenna","sequence":"additional","affiliation":[{"name":"Monogram Biosciences , South San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Lie","sequence":"additional","affiliation":[{"name":"Monogram Biosciences , South San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusica","family":"Curanovic","sequence":"additional","affiliation":[{"name":"Monogram Biosciences , South San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Winslow","sequence":"additional","affiliation":[{"name":"Monogram Biosciences , South San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California, San Diego , San Diego, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M","family":"Marra","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, University of Washington , Seattle, Washington , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah H","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Clifford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University at St. Louis , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Allen","family":"McCutchan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego , San Diego, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin B","family":"Gelman","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Cell Biology, UTMB , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Robinson-Papp","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mt. 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