{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:09:09Z","timestamp":1774501749451,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03AG067995-02"],"award-info":[{"award-number":["R03AG067995-02"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG070941"],"award-info":[{"award-number":["R01AG070941"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066444"],"award-info":[{"award-number":["P30AG066444"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG003991"],"award-info":[{"award-number":["P01AG003991"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG026276"],"award-info":[{"award-number":["P01AG026276"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01NR015738"],"award-info":[{"award-number":["R01NR015738"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01DA054009"],"award-info":[{"award-number":["R01DA054009"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>As people with human immunodeficiency virus (HIV) (PWH) age, it remains unclear whether they are at higher risk for age-related neurodegenerative disorders\u2014for example, Alzheimer disease (AD)\u2014and, if so, how to differentiate HIV-associated neurocognitive impairment from AD. We examined a clinically available blood biomarker test for AD (plasma amyloid-\u03b2 [A\u03b2] 42\/A\u03b240 ratio) in PWH who were cognitively normal (PWH_CN) or cognitively impaired (PWH_CI) and people without HIV (PWoH) who were cognitively normal (PWoH_CN) or had symptomatic AD (PWoH_AD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 66 PWH (age &amp;gt;40 years) (HIV RNA &amp;lt;50 copies\/mL) and 195 PWoH provided blood samples, underwent magnetic resonance imaging, and completed a neuropsychological battery or clinical dementia rating scale. Participants were categorized by impairment (PWH_CN, n = 43; PWH_CI, n = 23; PWoH_CN, n = 138; PWoH_AD, n = 57). Plasma A\u03b242 and A\u03b240 concentrations were obtained using a liquid chromatography\u2013tandem mass spectrometry method to calculate the PrecivityAD amyloid probability score (APS). The APS incorporates age and apolipoprotein E proteotype into a risk score for brain amyloidosis. Plasma A\u03b242\/A\u03b240 ratios and APSs were compared between groups and assessed for relationships with hippocampal volumes or cognition and HIV clinical characteristics (PWH only).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The plasma A\u03b242\/A\u03b240 ratio was significantly lower, and the APS higher, in PWoH_AD than in other groups. A lower A\u03b242\/A\u03b240 ratio and higher APS was associated with smaller hippocampal volumes for PWoH_AD. The A\u03b242\/A\u03b240 ratio and APS were not associated with cognition or HIV clinical measures for PWH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The plasma A\u03b242\/A\u03b240 ratio can serve as a screening tool for AD and may help differentiate effects of HIV from AD within PWH, but larger studies with older PWH are needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciad001","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T01:57:41Z","timestamp":1673143061000},"page":"1776-1783","source":"Crossref","is-referenced-by-count":6,"title":["Plasma A\u03b242\/A\u03b240 Ratios in Older People With Human Immunodeficiency Virus"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-241X","authenticated-orcid":false,"given":"Sarah A","family":"Cooley","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University in St Louis , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St Louis , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7107-3651","authenticated-orcid":false,"given":"Anna","family":"Boerwinkle","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St Louis , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin E","family":"Yarasheski","sequence":"additional","affiliation":[{"name":"C2N Diagnostics , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris M","family":"Kirmess","sequence":"additional","affiliation":[{"name":"C2N Diagnostics , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R","family":"Meyer","sequence":"additional","affiliation":[{"name":"C2N Diagnostics , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne E","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St Louis , St Louis, Missouri , USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St Louis , St Louis, Missouri , USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine , St Louis, Missouri , USA"},{"name":"Department of Radiology, Washington University in St Louis , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Fagan","sequence":"additional","affiliation":[{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beau M","family":"Ances","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St Louis , St Louis, Missouri , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane A","family":"O\u2019Halloran","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine , St Louis, Missouri , 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