{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:13:22Z","timestamp":1790766802540,"version":"4.1.0"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We compared 6 new interferon-\u03b3 release assays (IGRAs; hereafter index tests: QFT-Plus, QFT-Plus CLIA, QIAreach, Wantai TB-IGRA, Standard E TB-Feron, and T-SPOT.TB\/T-Cell Select) with World Health Organization (WHO)\u2013endorsed tests for tuberculosis infection (hereafter reference tests).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data sources (1 January 2007\u201318 August 2021) were Medline, Embase, Web of Science, Cochrane Database of Systematic Reviews, and manufacturers\u2019 data. Cross-sectional and cohort studies comparing the diagnostic performance of index and reference tests were selected. The primary outcomes of interest were the pooled differences in sensitivity and specificity between index and reference tests. The certainty of evidence (CoE) was summarized using the GRADE approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty-seven studies were included (44 evaluated the QFT-Plus, 4 QFT-Plus CLIA, 3 QIAreach, 26 TB-IGRA, 10 TB-Feron [1 assessing the QFT-Plus], and 1 T-SPOT.TB\/T-Cell Select). Compared to the QFT-GIT, QFT Plus\u2019s sensitivity was 0.1 percentage points lower (95% confidence interval [CI], \u22122.8 to 2.6; CoE: moderate), and its specificity 0.9 percentage points lower (95% CI, \u22121.0 to \u2212.9; CoE: moderate). Compared to QFT-GIT, TB-IGRA's sensitivity was 3.0 percentage points higher (95% CI, \u2212.2 to 6.2; CoE: very low), and its specificity 2.6 percentage points lower (95% CI, \u22124.2 to \u22121.0; CoE: low). Agreement between the QFT-Plus CLIA and QIAreach with QFT-Plus was excellent (pooled \u03ba statistics of 0.86 [95% CI, .78 to .94; CoE: low]; and 0.96 [95% CI, .92 to 1.00; CoE: low], respectively). The pooled \u03ba statistic comparing the TB-Feron and the QFT-Plus or QFT-GIT was 0.85 (95% CI, .79 to .92; CoE: low).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The QFT-Plus and the TB-IGRA have very similar sensitivity and specificity as WHO-approved IGRAs.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciad030","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T05:14:49Z","timestamp":1674278089000},"page":"1989-1999","source":"Crossref","is-referenced-by-count":43,"title":["Assessing the Diagnostic Performance of New Commercial Interferon-\u03b3 Release Assays for<i>Mycobacterium tuberculosis<\/i>Infection: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7169-8459","authenticated-orcid":false,"given":"Edgar","family":"Ortiz-Brizuela","sequence":"first","affiliation":[{"name":"McGill International Tuberculosis Centre, Department of Medicine, McGill University , Montreal, Quebec , Canada"},{"name":"Department of Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lika","family":"Apriani","sequence":"additional","affiliation":[{"name":"Tuberculosis Working Group, Research Centre for Care and Control of Infectious Diseases, Universitas Padjadjaran , Bandung , Indonesia"},{"name":"Department of Public Health, Faculty of Medicine, Universitas Padjadjaran , Bandung , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lachapelle-Chisholm","sequence":"additional","affiliation":[{"name":"McGill International Tuberculosis Centre, Department of Medicine, McGill University , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Miedy","sequence":"additional","affiliation":[{"name":"McGill University Health Center, Department of Intensive Care Unit, McGill University , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Lan","sequence":"additional","affiliation":[{"name":"McGill International Tuberculosis Centre, Department of Medicine, McGill University , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Korobitsyn","sequence":"additional","affiliation":[{"name":"Global Tuberculosis Programme, World Health Organization , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazir","family":"Ismail","sequence":"additional","affiliation":[{"name":"Global Tuberculosis Programme, World Health Organization , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Menzies","sequence":"additional","affiliation":[{"name":"McGill International Tuberculosis Centre, Department of Medicine, McGill University , Montreal, Quebec , Canada"},{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, Montreal Chest Institute, McGill University , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"2023060818540828700_ciad030-B1","first-page":"1","article-title":"Effectiveness of interventions for reducing TB incidence in countries with low TB incidence: a systematic review of reviews","volume":"28","author":"Collin","year":"2019","journal-title":"Eur Res Rev"},{"key":"2023060818540828700_ciad030-B2","volume-title":"WHO consolidated guidelines on tuberculosis: module 1: prevention: tuberculosis 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