{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:27:13Z","timestamp":1790792833364,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Programme Hospitalier de Recherche Clinique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The optimal duration of antimicrobial therapy for urinary tract infections (UTIs) in men remains controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To compare 7 days to 14 days of total antibiotic treatment for febrile UTIs in men, this multicenter randomized, double-blind. placebo-controlled noninferiority trial enrolled 282 men from 27 centers in France. Men were eligible if they had a febrile UTI and urine culture showing a single uropathogen. Participants were treated with ofloxacin or a third-generation cephalosporin at day 1, then randomized at day 3\u20134 to either continue ofloxacin for 14 days total treatment, or for 7 days followed by placebo until day 14. The primary endpoint was treatment success, defined as a negative urine culture and the absence of fever and of subsequent antibiotic treatment between the end of treatment and 6 weeks after day 1. Secondary endpoints included recurrent UTI within weeks 6 and 12 after day 1, rectal carriage of antimicrobial-resistant Enterobacterales, and drug-related events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two hundred forty participants were randomly assigned to receive antibiotic therapy for 7 days (115 participants) or 14 days (125 participants). In the intention-to-treat analysis, treatment success occurred in 64 participants (55.7%) in the 7-day group and in 97 participants (77.6%) in the 14-day group (risk difference, \u201321.9 [95% confidence interval, \u221233.3 to \u221210.1]), demonstrating inferiority. Adverse events during antibiotic therapy were reported in 4 participants in the 7-day arm and 7 in the 14-day arm. Rectal carriage of resistant Enterobacterales did not differ between both groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A treatment with ofloxacin for 7 days was inferior to 14 days for febrile UTI in men and should therefore not be recommended.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT02424461; Eudra-CT: 2013-001647-32.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciad070","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T05:25:45Z","timestamp":1676093145000},"page":"2154-2162","source":"Crossref","is-referenced-by-count":39,"title":["Antimicrobial for 7 or 14 Days for Febrile Urinary Tract Infection in Men: A Multicenter Noninferiority Double-Blind, Placebo-Controlled, Randomized Clinical Trial"],"prefix":"10.1093","volume":"76","author":[{"given":"Matthieu","family":"Lafaurie","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, H\u00f4pital Saint-Louis-H\u00f4pital Lariboisi\u00e8re, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chevret","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, H\u00f4pital Saint-Louis, AP-HP, Paris, France; Universit\u00e9 Paris Diderot, Inserm S 717"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Emergency Department, H\u00f4pital Saint-Louis, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mongiat-Artus","sequence":"additional","affiliation":[{"name":"Department of Urology, H\u00f4pital Saint-Louis, AP-HP , Paris , 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