{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:19:12Z","timestamp":1789708752819,"version":"4.0.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI149614"],"award-info":[{"award-number":["R01 AI149614"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Secretaria de Estado de Sau\u0301de de Minas Gerais"},{"name":"Secretaria de Estado de Planejamento de Minas Gerais"},{"name":"Instituto Rene\u0301 Rachou"},{"name":"Fundac\u0327\u00e3o Oswaldo Cruz"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["404192-2019-0"],"award-info":[{"award-number":["404192-2019-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["R01 AI149614"],"award-info":[{"award-number":["R01 AI149614"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Fundac\u0327\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["VPPIS-004- FIO-18-32"],"award-info":[{"award-number":["VPPIS-004- FIO-18-32"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01989-18"],"award-info":[{"award-number":["APQ-01989-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordenac\u0327\u00e3o de Aperfeic\u0327oamento de Pessoal de N\u0131\u0301vel Superior","award":["88882.348380\/2010-1"],"award-info":[{"award-number":["88882.348380\/2010-1"]}]},{"name":"Coordenac\u0327\u00e3o de Aperfeic\u0327oamento de Pessoal de N\u0131\u0301vel Superior","award":["0001"],"award-info":[{"award-number":["0001"]}]},{"name":"CNPq Research Fellows"},{"name":"Hospital Eduardo de Menezes"},{"name":"Funda\u00e7\u00e3o de Hospitais do Estado de Minas Gerais"},{"name":"US Collaborative Biomedical Research Program"},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002248","name":"MS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002248","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hospital Eduardo de Menezes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late-relapsing hepatitis after yellow fever (LHep-YF) during the convalescent phase of the disease has been described during recent yellow fever (YF) outbreaks in Brazil. LHep-YF is marked by a rebound in liver enzymes and nonspecific clinical manifestations around 46\u201360 days after YF symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here we have characterized the clinical course and risk factors for LHep-YF using data from a representative cohort of patients who survived YF in Brazil, 2017\u20132018. A total of 221 YF-positive patients were discharged from the infectious disease reference hospital in Minas Gerais and were followed up at 30, 45, and 60 days post\u2013symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 46 to 60 days post\u2013symptom onset, 16% of YF patients (n = 36\/221) exhibited a rebound of aminotransferases (aspartate aminotransferase or alanine aminotransferase &amp;gt;500 IU\/L), alkaline phosphatase, and total bilirubin levels. Other etiologies of liver inflammation such as infectious hepatitis, autoimmune hepatitis, and metabolic liver disease were ruled out. Jaundice, fatigue, headache, and low platelet levels were associated with LHep-YF. Demographic factors, clinical manifestations, laboratory tests, ultrasound findings, and viral load during the acute phase of YF were not associated with the occurrence of LHep-YF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings provide new data on the clinical course of Late-relapsing hepatitis during the convalescent phase of YF and highlight the need for extended patient follow-up after acute YF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciad249","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:40:46Z","timestamp":1682509246000},"page":"565-573","source":"Crossref","is-referenced-by-count":7,"title":["Characterization and Investigation of Risk Factors for Late-Relapsing Hepatitis After Yellow Fever"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-6300","authenticated-orcid":false,"given":"Izabela Mauricio de","family":"Rezende","sequence":"first","affiliation":[{"name":"Laboratory of Viruses, Microbiology Department, Federal University of Minas Gerais , Belo Horizonte , Brazil"},{"name":"Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine , California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max A","family":"McClure","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine , California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo S","family":"Pereira","sequence":"additional","affiliation":[{"name":"Eduardo de Menezes Hospital , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana R B","family":"Fradico","sequence":"additional","affiliation":[{"name":"Integrated Group of Biomarkers Research, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation\/FIOCRUZ , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana R C","family":"Cenachi","sequence":"additional","affiliation":[{"name":"Eduardo de Menezes Hospital , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre S","family":"Moura","sequence":"additional","affiliation":[{"name":"Eduardo de Menezes Hospital , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa L de A","family":"Paladino","sequence":"additional","affiliation":[{"name":"Eduardo de Menezes Hospital , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita T","family":"Dutra","sequence":"additional","affiliation":[{"name":"Eduardo de Menezes Hospital , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A","family":"Alves","sequence":"additional","affiliation":[{"name":"Immunology of Viral Diseases, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation\/FIOCRUZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo A P","family":"Xavier","sequence":"additional","affiliation":[{"name":"Immunology of Viral Diseases, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation\/FIOCRUZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo F do C","family":"Said","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario B","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Eduardo de Menezes Hospital , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaysa D P","family":"Gama","sequence":"additional","affiliation":[{"name":"Eduardo de Menezes Hospital , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olindo A","family":"Martins-Filho","sequence":"additional","affiliation":[{"name":"Integrated Group of Biomarkers Research, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation\/FIOCRUZ , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P","family":"Monath","sequence":"additional","affiliation":[{"name":"Crozet BioPharma LLC , Lexington, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[{"name":"Integrated Group of Biomarkers Research, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation\/FIOCRUZ , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00e2nia P","family":"Drumond","sequence":"additional","affiliation":[{"name":"Laboratory of Viruses, Microbiology Department, Federal University of Minas Gerais , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelle D","family":"LaBeaud","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine , California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Yellow Fever Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Maur\u00edcio","family":"Castro Bragato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argus 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