{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:41:02Z","timestamp":1791265262478,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Except for cryptococcosis, fungal infection of the central nervous system (FI-CNS) is a rare but severe complication. Clinical and radiological signs are non-specific, and the value of conventional mycological diagnosis is very low. This study aimed to assess the value of \u03b21,3-D-glucan (BDG) detection in the cerebrospinal fluid (CSF) of non-neonatal non-cryptococcosis patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cases associated with BDG assay in the CSF performed in 3 French University Hospitals over 5 years were included. Clinical, radiological, and mycological results were used to classify the episodes as proven\/highly probable, probable, excluded, and unclassified FI-CNS. Sensitivity and specificity were compared to that calculated from an exhaustive review of the literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 228 episodes consisting of 4, 7, 177, and 40 proven\/highly probable, probable, excluded, and unclassified FI-CNS, respectively, were analysed. The sensitivity of BDG assay in CSF to diagnose proven\/highly probable\/probable FI-CNS ranged from 72.7% [95% confidence interval {CI}: 43.4%\u201290.2%] to 100% [95% CI: 51%\u2012100%] in our study and was 82% in the literature. For the first time, specificity could be calculated over a large panel of pertinent controls and was found at 81.8% [95% CI: 75.3%\u201286.8%]. Bacterial neurologic infections were associated with several false positive results<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite its sub-optimal performance, BDG assay in the CSF should be added to the diagnostic armamentarium for FI-CNS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciad274","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T08:17:19Z","timestamp":1683101839000},"page":"711-720","source":"Crossref","is-referenced-by-count":16,"title":["\u00df-D-Glucan Assay in the Cerebrospinal Fluid for the Diagnosis of Non-cryptococcal Fungal Infection of the Central Nervous System: A Retrospective Multicentric Analysis and a Comprehensive Review of the Literature"],"prefix":"10.1093","volume":"77","author":[{"given":"Jeanne","family":"Bigot","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, H\u00f4pital Saint-Antoine, Service de Parasitologie-Mycologie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Leroy","sequence":"additional","affiliation":[{"name":"CHU Lille, Laboratoire de Parasitologie-Mycologie, Univ. Lille, Glycobiology in Fungal Pathogenesis & Clinical Applications, Inserm U1285, CNRS, UMR 8576\u2014UGSF-Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taieb","family":"Chouaki","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, University Hospital of Amiens , Amiens , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Cholley","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, APHP, H\u00f4pital Saint Antoine, Service de Radiologie G\u00e9n\u00e9rale , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efke","family":"Big\u00e9","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, APHP, H\u00f4pital Saint Antoine, Service de R\u00e9animation M\u00e9dicale , Paris , France"},{"name":"Department of Intensive Care, Gustave Roussy Cancer Campus , Villejuif , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Dominique","family":"Tabone","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019H\u00e9matologie et d\u2019Oncologie P\u00e9diatrique, Sorbonne Universit\u00e9, APHP, H\u00f4pital Armand Trousseau , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eolia","family":"Brissot","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM U938, APHP, H\u00f4pital Saint Antoine, Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Thorez","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, APHP, H\u00f4pital St Antoine, Service de Parasitologie-Mycologie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Maizel","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitaire Amiens-Picardie , Amiens , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Surgical ICU, University Hospital of Amiens Picardy , Amiens , France"},{"name":"Universit\u00e9 de Picardie Jules Verne, Unit\u00e9 de recherche 7518 SSPC, CHU Amiens Picardie, Service d\u2019Anesth\u00e9sie et de R\u00e9animation Polyvalente , Amiens , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boualem","family":"Sendid","sequence":"additional","affiliation":[{"name":"CHU Lille, Laboratoire de Parasitologie-Mycologie, Univ. 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