{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:37:55Z","timestamp":1791509875647,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"German Centre for International Migration and Development"},{"name":"HHMI-Wellcome","award":["208710\/Z\/17\/Z"],"award-info":[{"award-number":["208710\/Z\/17\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>All World Health Organization (WHO) pre-qualified rabies vaccines for humans are inactivated tissue culture rabies virus formulations produced for intramuscular (IM) administration. Due to costs and vaccine shortage, dose-saving intradermal (ID) administration of rabies post-exposure prophylaxis (PEP) is encouraged by WHO. This study compared the immunogenicity of the ID 2-site, 3-visit Institut Pasteur Cambodge (IPC) PEP regimen to the IM 1-site, 4-visit 4-dose Essen regimen using Verorab vaccine (Sanofi). The development of neutralizing antibodies (nAbs) and T cell response was assessed in 210 patients with a category II or III animal exposure in a rabies-endemic country. At day 28, all participants developed nAbs (\u22650.5 IU\/mL), irrespective of PEP scheme, age, or administration of rabies immunoglobulin. T cell response and nAb titers were similar for both PEP schemes. This study demonstrated that the 1-week ID IPC regimen is as effective as the 2-week IM 4-dose Essen regimen in inducing an anti-rabies immune response under real-life PEP.<\/jats:p>","DOI":"10.1093\/cid\/ciad304","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T11:33:10Z","timestamp":1687001590000},"page":"910-916","source":"Crossref","is-referenced-by-count":13,"title":["Side-by-side Comparative Study of the Immunogenicity of the Intramuscular and Intradermal Rabies Post-exposure Prophylaxis Regimens in a Cohort of Suspected Rabies Virus Exposed Individuals"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-7618","authenticated-orcid":false,"given":"Heidi","family":"Auerswald","sequence":"first","affiliation":[{"name":"Virology Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvino","family":"Maestri","sequence":"additional","affiliation":[{"name":"Immunology Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sothy","family":"Touch","sequence":"additional","affiliation":[{"name":"Rabies Prevention Center, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraden","family":"In","sequence":"additional","affiliation":[{"name":"Virology Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa","family":"Ya","sequence":"additional","affiliation":[{"name":"Immunology Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borita","family":"Heng","sequence":"additional","affiliation":[{"name":"Immunology Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Bosch-Castells","sequence":"additional","affiliation":[{"name":"Global Medical, Sanofi , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christele","family":"Augard","sequence":"additional","affiliation":[{"name":"Global Medical, Sanofi , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Petit","sequence":"additional","affiliation":[{"name":"Global Medical, Sanofi , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-3037","authenticated-orcid":false,"given":"Philippe","family":"Dussart","sequence":"additional","affiliation":[{"name":"Virology Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiksing","family":"Peng","sequence":"additional","affiliation":[{"name":"Rabies Prevention Center, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke","family":"Cantaert","sequence":"additional","affiliation":[{"name":"Immunology Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowath","family":"Ly","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Pasteur Network , Phnom 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