{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:27:45Z","timestamp":1791656865838,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030_175585"],"award-info":[{"award-number":["320030_175585"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The currently recommended benzimidazole monotherapy is insufficiently effective to control infection with the soil-transmitted helminth Trichuris trichiura. Ivermectin-albendazole combination has shown promising, but setting-dependent efficacy, with therapeutic underperformance in C\u00f4te d\u2019Ivoire. We evaluated whether moxidectin-albendazole could serve as an alternative to albendazole monotherapy in C\u00f4te d\u2019Ivoire.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this community-based, randomized, placebo-controlled, parallel-group superiority trial, individuals aged 12\u201360 years were screened for T. trichiura eggs in their stool using quadruplicate Kato-Katz thick smears. Diagnostically and clinically eligible participants were randomly assigned (1:1:1) to receive single oral doses of moxidectin (8 mg) and albendazole (400 mg), ivermectin (200 \u00b5g\/kg) and albendazole (400 mg), or albendazole (400 mg) and placebo. The primary outcome was proportion cured, ie, cure rate (CR), assessed at 2\u20133 weeks post-treatment. Safety endpoints were assessed pre-treatment and at 3 and 24 hours post-treatment.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n For the 210 participants with primary outcome data, we observed CRs of 15.3% in the moxidectin-albendazole arm and 22.5% in the ivermectin-albendazole arm, which did not differ significantly from the CR of 13.4% in the albendazole arm (differences: 1.8%-points [95% confidence interval: \u221210.1 to 13.6] and 9.1%-points [\u22123.9 to 21.8], respectively). Most common adverse events were abdominal pain (range across arms: 11.9%\u201320.9%), headache (4.7%\u201314.3%), and itching (5.8%\u201313.1%), which were predominantly mild and transient.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n All therapies showed similar low efficacy in treating trichuriasis in C\u00f4te d\u2019Ivoire. Alternative treatment options need to be evaluated, and further analyses should be conducted to understand the lack of enhanced activity of the combination therapies in C\u00f4te d\u2019Ivoire.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trials Registration<\/jats:title>\n NCT04726969.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/cid\/ciad387","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T16:38:16Z","timestamp":1687624696000},"page":"1294-1302","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy and Safety of Moxidectin-Albendazole and Ivermectin-Albendazole Combination Therapy Compared to Albendazole Monotherapy in Adolescents and Adults Infected with Trichuris trichiura<\/i>: A Randomized, Controlled Superiority Trial"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-6687","authenticated-orcid":false,"given":"Viviane P","family":"Sprecher","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute (Swiss TPH) , Allschwil , Switzerland"},{"name":"University of Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-6068","authenticated-orcid":false,"given":"Jean T","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny , Abidjan , C\u00f4te d\u2019Ivoire"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire , Abidjan , C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-8198","authenticated-orcid":false,"given":"Eveline","family":"H\u00fcrlimann","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute (Swiss TPH) , Allschwil , Switzerland"},{"name":"University of Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-401X","authenticated-orcid":false,"given":"Jan","family":"Hattendorf","sequence":"additional","affiliation":[{"name":"University of Basel , Basel , Switzerland"},{"name":"Department of Epidemiology and Public Health , Swiss Tropical and Public Health Institute (Swiss TPH), Allschwil , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-3521","authenticated-orcid":false,"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute (Swiss TPH) , Allschwil , Switzerland"},{"name":"University of Basel , Basel , 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