{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:35:40Z","timestamp":1793698540607,"version":"4.5.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01HL123336"],"award-info":[{"award-number":["U01HL123336"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01HL123339"],"award-info":[{"award-number":["U01HL123339"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kowa Pharmaceuticals"},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pericoronary adipose tissue (PCAT) may influence plaque development through inflammatory mechanisms. We assessed PCAT density, as a measure of pericoronary inflammation, in relationship to coronary plaque among people with human immunodeficiency virus (HIV [PWH]) and to a matched control population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this baseline analysis of 727 participants of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) Mechanistic Substudy, we related computed tomography\u2013derived PCAT density to presence and extent (Leaman score) of coronary artery disease (CAD), noncalcified plaque, coronary artery calcium (CAC), and vulnerable plaque features using multivariable logistic regression analyses. We further compared the PCAT density between PWH and age, sex, body mass index, CAC score, and statin use\u2013matched controls from the community-based Framingham Heart Study (N = 464), adjusting for relevant clinical covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 727 REPRIEVE participants (age 50.8 \u00b1 5.8 years; 83.6% [608\/727] male), PCAT density was higher in those with (vs without) coronary plaque, noncalcified plaque, CAC &amp;gt;0, vulnerable plaque, and high CAD burden (Leaman score &amp;gt;5) (P &amp;lt; .001 for each comparison). PCAT density related to prevalent coronary plaque (adjusted odds ratio [per 10 HU]: 1.44; 95% confidence interval, 1.22\u20131.70; P &amp;lt; .001), adjusted for clinical cardiovascular risk factors, body mass index, and systemic immune\/inflammatory biomarkers. Similarly, PCAT density related to CAC &amp;gt;0, noncalcified plaque, vulnerable plaque, and Leaman score &amp;gt;5 (all P \u2264 .002). PCAT density was greater among REPRIEVE participants versus Framingham Heart Study (\u221288.2 \u00b1 0.5 HU versus \u221290.6 \u00b1 0.4 HU; P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among PWH in REPRIEVE, a large primary cardiovascular disease prevention cohort, increased PCAT density independently associated with prevalence and severity of coronary plaque, linking increased coronary inflammation to CAD in PWH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciad419","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T05:46:49Z","timestamp":1689140809000},"page":"1676-1686","source":"Crossref","is-referenced-by-count":18,"title":["Pericoronary Adipose Tissue Density, Inflammation, and Subclinical Coronary Artery Disease Among People With HIV in the REPRIEVE Cohort"],"prefix":"10.1093","volume":"77","author":[{"given":"Borek","family":"Foldyna","sequence":"first","affiliation":[{"name":"Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mayrhofer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"},{"name":"Department of Health Economics, School of Business Studies, Stralsund University of Applied Sciences, Stralsund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markella V","family":"Zanni","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asya","family":"Lyass","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Boston University , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Barve","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Karady","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"McCallum","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia H","family":"Burdo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Inflammation and Center for NeuroVirology and Gene Editing, Temple University Lewis Katz School of Medicine , Philadelphia, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen V","family":"Fitch","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Paradis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelynne S","family":"Fulda","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa R","family":"Diggs","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald S","family":"Bloomfield","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke Global Health Institute and Duke Clinical Research Institute, Duke University , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D","family":"Malvestutto","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Ohio State University Medical Center , Columbus, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J","family":"Fichtenbaum","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A","family":"Aberg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai , New York, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S","family":"Currier","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J","family":"Ribaudo","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Innovative Imaging Consulting LLC , Waltham, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology), Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K","family":"Grinspoon","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"2024021012512739700_ciad419-B1","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1161\/CIR.0000000000000695","article-title":"Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association","volume":"140","author":"Feinstein","year":"2019","journal-title":"Circulation"},{"key":"2024021012512739700_ciad419-B2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamainternmed.2013.3728","article-title":"HIV infection and the risk of acute myocardial infarction","volume":"173","author":"Freiberg","year":"2013","journal-title":"JAMA Intern Med"},{"key":"2024021012512739700_ciad419-B3","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/CIRCULATIONAHA.117.033369","article-title":"Global burden of atherosclerotic cardiovascular disease in people living with HIV","volume":"138","author":"Shah","year":"2018","journal-title":"Circulation"},{"key":"2024021012512739700_ciad419-B4","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1210\/jc.2006-2190","article-title":"Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease","volume":"92","author":"Triant","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2024021012512739700_ciad419-B5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/jama.2012.6698","article-title":"Arterial inflammation in patients with HIV","volume":"308","author":"Subramanian","year":"2012","journal-title":"JAMA"},{"key":"2024021012512739700_ciad419-B6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/QAI.0000000000000138","article-title":"Increased arterial inflammation relates to high-risk coronary plaque morphology in HIV-infected patients","volume":"66","author":"Tawakol","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2024021012512739700_ciad419-B7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/infdis\/jix095","article-title":"Application of a novel CD206+ macrophage-specific arterial imaging strategy in HIV-infected individuals","volume":"215","author":"Zanni","year":"2017","journal-title":"J Infect Dis"},{"key":"2024021012512739700_ciad419-B8","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.14923","article-title":"Assessment of coronary artery disease with computed tomography angiography and inflammatory and immune activation biomarkers among adults with HIV eligible for primary cardiovascular prevention","volume":"4","author":"Hoffmann","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2024021012512739700_ciad419-B9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/QAI.0b013e3181a9992c","article-title":"Association of C-reactive protein and HIV infection with acute myocardial infarction","volume":"51","author":"Triant","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2024021012512739700_ciad419-B10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/QAI.0b013e3181f4b752","article-title":"Association of immunologic and virologic factors with myocardial infarction rates in a U.S. health care system","volume":"55","author":"Triant","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2024021012512739700_ciad419-B11","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/QAD.0b013e32835eca9b","article-title":"Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men","volume":"27","author":"Zanni","year":"2013","journal-title":"AIDS Lond Engl"},{"key":"2024021012512739700_ciad419-B12","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/infdis\/jiac301","article-title":"Increased macrophage-specific arterial infiltration relates to noncalcified plaque and systemic immune activation in people with human immunodeficiency virus","volume":"226","author":"Toribio","year":"2022","journal-title":"J Infect Dis"},{"key":"2024021012512739700_ciad419-B13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal2658","article-title":"Detecting human coronary inflammation by imaging perivascular fat","volume":"9","author":"Antonopoulos","year":"2017","journal-title":"Sci Transl Med"},{"key":"2024021012512739700_ciad419-B14","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(18)31114-0","article-title":"Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data","volume":"392","author":"Oikonomou","year":"2018","journal-title":"Lancet"},{"key":"2024021012512739700_ciad419-B15","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jamacardio.2018.1997","article-title":"Pericoronary adipose tissue computed tomography attenuation and high-risk plaque characteristics in acute coronary syndrome compared with stable coronary artery disease","volume":"3","author":"Goeller","year":"2018","journal-title":"JAMA Cardiol"},{"key":"2024021012512739700_ciad419-B16","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.122.014672","article-title":"Pericoronary adipose tissue attenuation in patients with acute coronary syndrome versus stable coronary artery disease","volume":"16","author":"Kuneman","year":"2023","journal-title":"Circ Cardiovasc Imaging"},{"key":"2024021012512739700_ciad419-B17","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1093\/ehjci\/jeac174","article-title":"Pericoronary fat attenuation index\u2014a new imaging biomarker and its diagnostic and prognostic utility: a systematic review and meta-analysis","volume":"23","author":"Sagris","year":"2022","journal-title":"Eur Heart J\u2014Cardiovasc Imaging"},{"key":"2024021012512739700_ciad419-B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ahj.2019.02.011","article-title":"Rationale and design of the mechanistic substudy of the randomized trial to prevent vascular events in HIV (REPRIEVE): effects of pitavastatin on coronary artery disease and inflammatory biomarkers","volume":"212","author":"Hoffmann","year":"2019","journal-title":"Am Heart J"},{"key":"2024021012512739700_ciad419-B19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ahj.2018.12.016","article-title":"Rationale and design of the randomized trial to prevent vascular events in HIV (REPRIEVE)","volume":"212","author":"Grinspoon","year":"2019","journal-title":"Am Heart J"},{"key":"2024021012512739700_ciad419-B20"},{"key":"2024021012512739700_ciad419-B21","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.jacc.2013.11.005","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Goff","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2024021012512739700_ciad419-B22","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.amjcard.2008.06.038","article-title":"Defining normal distributions of coronary artery calcium in women and men (from the Framingham Heart Study)","volume":"102","author":"Hoffmann","year":"2008","journal-title":"Am J Cardiol"},{"key":"2024021012512739700_ciad419-B23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"2024021012512739700_ciad419-B24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jcct.2014.07.003","article-title":"SCCT Guidelines for the interpretation and reporting of coronary CT angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee","volume":"8","author":"Leipsic","year":"2014","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"2024021012512739700_ciad419-B25","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jacc.2014.05.039","article-title":"High-risk plaque detected on coronary CT angiography predicts acute coronary syndromes independent of significant stenosis in acute chest pain: results from the ROMICAT-II trial","volume":"64","author":"Puchner","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2024021012512739700_ciad419-B26","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s10554-013-0232-8","article-title":"Coronary computed tomography angiography-adapted Leaman score as a tool to noninvasively quantify total coronary atherosclerotic burden","volume":"29","author":"Gon\u00e7alves P","year":"2013","journal-title":"Int J Cardiovasc Imaging"},{"key":"2024021012512739700_ciad419-B27","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","author":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","year":"2002","journal-title":"Circulation"},{"key":"2024021012512739700_ciad419-B28","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0735-1097(22)02227-6","article-title":"Usefulness of new method to quantify pericoronary adipose tissue on ECG-gated non-contrast chest CT scan","volume":"79","author":"Takahashi","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2024021012512739700_ciad419-B29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11883-019-0817-3","article-title":"Perivascular adipose tissue and coronary atherosclerosis: from biology to imaging phenotyping","volume":"21","author":"Lin","year":"2019","journal-title":"Curr Atheroscler Rep"},{"key":"2024021012512739700_ciad419-B30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.bjp.0707228","article-title":"Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide","volume":"151","author":"Gao","year":"2007","journal-title":"Br J Pharmacol"},{"key":"2024021012512739700_ciad419-B31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/CIRCRESAHA.108.182998","article-title":"Proinflammatory phenotype of perivascular adipocytes","volume":"104","author":"Chatterjee","year":"2009","journal-title":"Circ Res"},{"key":"2024021012512739700_ciad419-B32","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.jcmg.2018.11.032","article-title":"Peri-coronary adipose tissue density is associated with 18F-sodium fluoride coronary uptake in stable patients with high-risk plaques","volume":"12","author":"Jacek","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2024021012512739700_ciad419-B33","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/infdis\/jit508","article-title":"Noncalcified coronary atherosclerotic plaque and immune activation in HIV-infected women","volume":"208","author":"Fitch","year":"2013","journal-title":"J Infect Dis"},{"key":"2024021012512739700_ciad419-B34","author":"Antoniades"},{"key":"2024021012512739700_ciad419-B35","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jcct.2020.04.004","article-title":"Feasibility of measuring pericoronary fat from precontrast scans: effect of iodinated contrast on pericoronary fat attenuation","volume":"14","author":"Almeida","year":"2020","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"2024021012512739700_ciad419-B36"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciad419\/51231830\/ciad419.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/77\/12\/1676\/56656994\/ciad419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/77\/12\/1676\/56656994\/ciad419.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T12:52:30Z","timestamp":1707569550000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/77\/12\/1676\/7223664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,7,13]]},"published-print":{"date-parts":[[2023,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciad419","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,15]]},"published":{"date-parts":[[2023,7,13]]}}}