{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:55:28Z","timestamp":1777589728511,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Little data exist on the risk and outcomes of out-of-hospital cardiac arrest (OHCA) in people with HIV (PWH). We aimed to describe OHCA in PWH as compared with the general population in terms of incidence, characteristics, and survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This nationwide study assessed all individuals aged 18\u201385 years between 2001 and 2019 in Denmark. The cumulative incidence of OHCA was computed using cause-specific Cox models accounting for competing risk of death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 6 565 309 individuals, 6 925 (median age: 36; interquartile range [IQR]: 28\u201344 y; 74% males) were infected at some point with HIV. The incidence of OHCA was 149 (95% CI: 123\u2013180)\/100 000 person-years in PWH versus 64 (95% CI: 64\u201365)\/100 000 person-years in people without HIV (P &amp;lt; .001). Age at the time of cardiac arrest was 52 (IQR: 44\u201361) years in PWH versus 69 (IQR: 59\u201377) years in individuals without HIV (P &amp;lt; .001). In a multivariable model adjusted for age, sex, hypertension, diabetes, heart failure, ischemic heart disease, atrial fibrillation, chronic obstructive pulmonary disease, cancer, and renal failure, PWH had a 2-fold higher risk of OHCA (hazard ratio: 2.84; 95% CI: 2.36\u20133.43; P &amp;lt; .001). Thirty-day mortality (89% vs 88%; P = .80) was comparable to individuals without HIV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>HIV is an independent risk factor for OHCA, and those who experience OHCA with HIV are much younger than those without HIV. Almost 90% of PWH died 1 month after OHCA. Further research should strive to find out how to reduce OHCA occurrence in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciad422","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T05:29:21Z","timestamp":1689226161000},"page":"1578-1584","source":"Crossref","is-referenced-by-count":5,"title":["Out-of-Hospital Cardiac Arrest in Individuals With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-2437","authenticated-orcid":false,"given":"Rodrigue","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital-Rigshospitalet , Copenhagen , Denmark"},{"name":"Cardiology Department, University Hospital of Poitiers , Poitiers , France"},{"name":"Centre d'Investigation Clinique 1402, University Hospital of Poitiers , Poitiers , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0508-2503","authenticated-orcid":false,"given":"Peder Emil","family":"Warming","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital-Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-6248","authenticated-orcid":false,"given":"Carl Johann","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital-Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-1100","authenticated-orcid":false,"given":"Deepthi","family":"Rajan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital-Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014North Zealand , Hiller\u00f8d , Denmark"},{"name":"Department of Public Health, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-9385","authenticated-orcid":false,"given":"Thomas","family":"Benfield","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Infectious Diseases, Center of Research and Disruption of Infectious Diseases, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre , 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