{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:02Z","timestamp":1787008622642,"version":"build-2736575974"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI007433"],"award-info":[{"award-number":["T32AI007433"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over the last several decades, periprosthetic joint infection (PJI) has been increasing in incidence and is occurring in more complex patients. While there have been advances in both surgical and medical treatment strategies, there remain important gaps in our understanding. Here, we share our current approaches to the diagnosis and management of PJI, focusing on frequent clinical challenges and collaborative interdisciplinary care. The more detailed review including diagnosis, surgical considerations, and a detailed antimicrobial discussion is presented in the online version.<\/jats:p>","DOI":"10.1093\/cid\/ciad457","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T16:09:31Z","timestamp":1691424571000},"page":"939-940","source":"Crossref","is-referenced-by-count":7,"title":["Executive Summary: Periprosthetic Joint Infection\u2014Current Clinical Challenges"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1949-7884","authenticated-orcid":false,"given":"Sandra B","family":"Nelson","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodian A","family":"Pinkney","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia F","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-7082","authenticated-orcid":false,"given":"Aaron J","family":"Tande","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"2024041009401930200_ciad457-B1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1007\/s00264-017-3647-3","article-title":"Diagnostic accuracy of alpha-defensin in periprosthetic joint infection: a systematic review and meta-analysis","volume":"41","author":"Yuan","year":"2017","journal-title":"Int Orthop"},{"key":"2024041009401930200_ciad457-B2","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.arth.2020.12.018","article-title":"Alpha-defensin offers limited utility in routine workup of periprosthetic joint infection","volume":"36","author":"Kleeman-Forsthuber","year":"2021","journal-title":"J Arthroplasty"},{"key":"2024041009401930200_ciad457-B3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2106\/JBJS.17.00434","article-title":"Diagnosis of periprosthetic joint infection: the potential of next-generation sequencing","volume":"100","author":"Tarabichi","year":"2018","journal-title":"J Bone Joint Surg Am"},{"key":"2024041009401930200_ciad457-B4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/cid\/ciac733","article-title":"Next-generation sequencing supports targeted antibiotic treatment for culture negative orthopedic infections","volume":"76","author":"Kullar","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2024041009401930200_ciad457-B5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13063-016-1213-8","article-title":"One-stage or two-stage revision surgery for prosthetic hip joint infection\u2014the INFORM trial: a study protocol for a randomised controlled trial","volume":"17","author":"Strange","year":"2016","journal-title":"Trials"},{"key":"2024041009401930200_ciad457-B6","year":"2023"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/77\/7\/939\/57196986\/ciad457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/77\/7\/939\/57196986\/ciad457.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T05:41:24Z","timestamp":1712727684000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/77\/7\/939\/7289507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":6,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,10,5]]},"published-print":{"date-parts":[[2023,10,5]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciad457","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10,1]]},"published":{"date-parts":[[2023,10,1]]}}}