{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:39:38Z","timestamp":1782272378952,"version":"3.54.5"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100020365","name":"CDC Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"WHO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Edward Francis Small Teaching Hospital"},{"name":"CDC Atlanta"},{"name":"Ministry of Health of Burkina Faso"},{"name":"Edward Francis Small Teaching Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A low-level risk of intussusception following rotavirus vaccination has been observed in some settings and may vary by vaccine type. We examined the association between RotaTeq vaccination and intussusception in low-income settings in a pooled analysis from 5 African countries that introduced RotaTeq into their national immunization program.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Active surveillance was conducted at 20 hospitals to identify intussusception cases. A standard case report form was completed for each enrolled child, and vaccination status was determined by review of the child's vaccination card. The pseudo-likelihood adaptation of self-controlled case-series method was used to assess the association between RotaTeq administration and intussusception in the 1\u20137, 8\u201321, and 1\u201321 day periods after each vaccine dose in infants aged 28\u2013245 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Data from 318 infants with confirmed rotavirus vaccination status were analyzed. No clustering of cases occurred in any of the risk windows after any of the vaccine doses. Compared with the background risk of naturally occurring intussusception, no increased risk was observed after dose 1 in the 1\u20137 day (relative incidence = 2.71; 95% confidence interval [CI] = 0.47\u20138.03) or the 8\u201321 day window (relative incidence = 0.77; 95%CI = 0.0\u20132.69). Similarly, no increased risk of intussusception was observed in any risk window after dose 2 or 3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>RotaTeq vaccination was not associated with increased risk of intussusception in this analysis from 5 African countries. This finding mirrors results from similar analyses with other rotavirus vaccines in low-income settings and highlights the need for vaccine-specific and setting-specific risk monitoring.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciad492","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:35:01Z","timestamp":1692444901000},"page":"210-216","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Intussusception Following Pentavalent Rotavirus Vaccine (RotaTeq) Administration in 5 African Countries"],"prefix":"10.1093","volume":"78","author":[{"given":"Jacqueline E","family":"Tate","sequence":"first","affiliation":[{"name":"US Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M","family":"Mwenda","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Office for Africa , Brazzaville , Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adama Mamby","family":"Keita","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development , Bamako , Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toussaint Wendlamita","family":"Tapsoba","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire P\u00e9diatrique Charles de Gaulle , Ouagadougou , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Ngendahayo","sequence":"additional","affiliation":[{"name":"King Faisal Hospital , Kigali , Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertin Dibi","family":"Kouam\u00e9","sequence":"additional","affiliation":[{"name":"University Hospital of Yopougon , Abidjan , Cote d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadou Lamin","family":"Samateh","sequence":"additional","affiliation":[{"name":"Ministry of Health , Banjul , The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Aliabadi","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seydou","family":"Sissoko","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development , Bamako , Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacouba","family":"Traore","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sourou SANOU de Bobo Dioulasso , Bobo Dioulasso , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Bayisenga","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Butare , Butare , Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moufidath","family":"Sounkere-Soro","sequence":"additional","affiliation":[{"name":"University Hospital of Yopougon , Abidjan , Cote d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheriffo","family":"Jagne","sequence":"additional","affiliation":[{"name":"National Public Health Reference Laboratory, Ministry of Health , Banjul , The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M","family":"Burke","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Onwuchekwa","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development , Bamako , Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Ouattara","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office , Ouagadougou , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B","family":"Bikoroti","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Kigali , Kigali , Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kofi","family":"N\u2019Zue","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office , Abidjan , Cote d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Leshem","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumar","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Gabriel Tour\u00e9 , Bamako , Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issa","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Ministry of Health, Expanded Program on Immunizations , Ouagadougou , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine","family":"Uwimana","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Kigali , Kigali , Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samba","family":"Sow","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development , Bamako , Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh D","family":"Parashar","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the African Intussusception Surveillance Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Zampou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulie","family":"Bah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alhagie Papa","family":"Sey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariama","family":"Sonko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves C M","family":"Bizumuremyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violette","family":"Mukanyange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Niwenkunda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Twagirayezu","family":"Nkurunziza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,19]]},"reference":[{"key":"2024012801162624000_ciad492-B1","doi-asserted-by":"crossref","first-page":"e68482","DOI":"10.1371\/journal.pone.0068482","article-title":"Childhood intussusception: a literature review","volume":"8","author":"Jiang","year":"2013","journal-title":"PLoS One"},{"key":"2024012801162624000_ciad492-B2","first-page":"577","article-title":"Intussusception among recipients of rotavirus vaccine","volume":"48","author":"Centers for Disease Control and Prevention","year":"1999","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024012801162624000_ciad492-B3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJM200102223440804","article-title":"Intussusception among infants given an oral rotavirus vaccine","volume":"344","author":"Murphy","year":"2001","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B4","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1542\/peds.110.6.e67","article-title":"National Vaccine Advisory Committee","volume":"110","author":"Peter","year":"2002","journal-title":"Pediatrics"},{"key":"2024012801162624000_ciad492-B5","first-page":"1007","article-title":"Withdrawal of rotavirus vaccine recommendation","volume":"48","author":"Centers for Disease Control and Prevention","year":"1999","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024012801162624000_ciad492-B6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa052434","article-title":"Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis","volume":"354","author":"Ruiz-Palacios","year":"2006","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa052664","article-title":"Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine","volume":"354","author":"Vesikari","year":"2006","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJMoa0904797","article-title":"Effect of human rotavirus vaccine on severe diarrhea in African infants","volume":"362","author":"Madhi","year":"2010","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0140-6736(10)60889-6","article-title":"Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial","volume":"376","author":"Armah","year":"2010","journal-title":"Lancet"},{"key":"2024012801162624000_ciad492-B10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0140-6736(10)60755-6","article-title":"Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial","volume":"376","author":"Zaman","year":"2010","journal-title":"Lancet"},{"key":"2024012801162624000_ciad492-B11","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/infdis\/jiaa081","article-title":"Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children &lt;5 years old: 2006\u20132019","volume":"222","author":"Burnett","year":"2020","journal-title":"J Infect Dis"},{"key":"2024012801162624000_ciad492-B12","doi-asserted-by":"crossref","first-page":"e893","DOI":"10.1016\/S2214-109X(19)30207-4","article-title":"Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008\u201316: findings from the Global Rotavirus Surveillance Network","volume":"7","author":"Aliabadi","year":"2019","journal-title":"Lancet Glob Health"},{"key":"2024012801162624000_ciad492-B13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa1311738","article-title":"Risk of intussusception after monovalent rotavirus vaccination","volume":"370","author":"Weintraub","year":"2014","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1303164","article-title":"Intussusception risk after rotavirus vaccination in U.S. infants","volume":"370","author":"Yih","year":"2014","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B15","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/cid\/cit520","article-title":"Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program","volume":"57","author":"Carlin","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2024012801162624000_ciad492-B16","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1016\/j.vaccine.2016.04.050","article-title":"The risk of intussusception following monovalent rotavirus vaccination in England: a self-controlled case-series evaluation","volume":"34","author":"Stowe","year":"2016","journal-title":"Vaccine"},{"key":"2024012801162624000_ciad492-B17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jpeds.2015.03.038","article-title":"Intussusception and monovalent rotavirus vaccination in Singapore: self-controlled case series and risk-benefit study","volume":"167","author":"Yung","year":"2015","journal-title":"J Pediatr"},{"key":"2024012801162624000_ciad492-B18","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1056\/NEJMoa1012952","article-title":"Intussusception risk and health benefits of rotavirus vaccination in Mexico and Brazil","volume":"364","author":"Patel","year":"2011","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B19","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/INF.0b013e318253add3","article-title":"Postmarketing surveillance of intussusception following mass introduction of the attenuated human rotavirus vaccine in Mexico","volume":"31","author":"Velazquez","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"2024012801162624000_ciad492-B20","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/cid\/ciz431","article-title":"Evaluation of intussusception after oral monovalent rotavirus vaccination in South Africa","volume":"70","author":"Groome","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2024012801162624000_ciad492-B21","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa1713909","article-title":"Evaluation of intussusception after monovalent rotavirus vaccination in Africa","volume":"378","author":"Tate","year":"2018","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B22","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1056\/NEJMoa2002276","article-title":"Intussusception after rotavirus vaccine introduction in India","volume":"383","author":"Reddy","year":"2020","journal-title":"N Engl J Med"},{"key":"2024012801162624000_ciad492-B23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.vaccine.2020.09.019","article-title":"Risk of intussusception after monovalent rotavirus vaccine (Rotavac) in Indian infants: a self-controlled case series analysis","volume":"39","author":"Group","year":"2021","journal-title":"Vaccine"},{"key":"2024012801162624000_ciad492-B24","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/j.vaccine.2020.05.093","article-title":"Assessment of risk of intussusception after pilot rollout of rotavirus vaccine in the Indian public health system","volume":"38","author":"Early Rollout of RN","year":"2020","journal-title":"Vaccine"},{"key":"2024012801162624000_ciad492-B25","first-page":"25","article-title":"Global Advisory Committee on Vaccine Safety, 4\u20135 December 2019","volume":"95","year":"2020","journal-title":"Wkly Epidemiol Rec"},{"issue":"5\u20136","key":"2024012801162624000_ciad492-B26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.vaccine.2003.09.016","article-title":"Acute intussusception in infants and children as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation","volume":"22","author":"Bines","year":"2004","journal-title":"Vaccine"},{"key":"2024012801162624000_ciad492-B27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0962280208092342","article-title":"The methodology of self-controlled case series studies","volume":"18","author":"Whitaker","year":"2009","journal-title":"Stat Methods Med Res"},{"key":"2024012801162624000_ciad492-B28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/biostatistics\/kxn013","article-title":"Case series analysis for censored, perturbed, or curtailed post-event exposures","volume":"10","author":"Farrington","year":"2009","journal-title":"Biostatistics"},{"issue":"Suppl 1","key":"2024012801162624000_ciad492-B29","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1086\/605035","article-title":"Oral rotavirus vaccines: how well will they work where they are needed most?","volume":"200","author":"Patel","year":"2009","journal-title":"J Infect Dis"},{"key":"2024012801162624000_ciad492-B30","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1016\/j.vaccine.2008.08.034","article-title":"Co-administration study in South African infants of a live-attenuated oral human rotavirus vaccine (RIX4414) and poliovirus vaccines","volume":"28","author":"Steele","year":"2010","journal-title":"Vaccine"},{"key":"2024012801162624000_ciad492-B31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/cid\/civ807","article-title":"Interference of monovalent, bivalent, and trivalent oral poliovirus vaccines on monovalent rotavirus vaccine immunogenicity in rural Bangladesh","volume":"62","author":"Emperador","year":"2016","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciad492\/51712887\/ciad492.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/78\/1\/210\/56438935\/ciad492.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/78\/1\/210\/56438935\/ciad492.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T01:17:01Z","timestamp":1706404621000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/78\/1\/210\/7246285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,19]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,8,19]]},"published-print":{"date-parts":[[2024,1,25]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciad492","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,15]]},"published":{"date-parts":[[2023,8,19]]}}}