{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:46:56Z","timestamp":1780638416725,"version":"3.54.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Ministry of Health and Social Services"},{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Qu\u00e9bec \u2013 Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>During the 2022 mpox outbreak, the province of Quebec, Canada, prioritized first doses for pre-exposure vaccination of people at high mpox risk, delaying second doses due to limited supply. We estimated single-dose mpox vaccine effectiveness (VE) adjusting for virus exposure risk based only on surrogate indicators available within administrative databases (eg, clinical record of sexually transmitted infections) or supplemented by self-reported risk factor information (eg, sexual contacts).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a test-negative case-control study between 19 June and 24 September 2022. Information from administrative databases was supplemented by questionnaire collection of self-reported risk factors specific to the 3-week period before testing. Two study populations were assessed: all within the administrative databases (All-Admin) and the subset completing the questionnaire (Sub-Quest). Logistic regression models adjusted for age, calendar-time and exposure-risk, the latter based on administrative indicators only (All-Admin and Sub-Quest) or with questionnaire supplementation (Sub-Quest).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 532 All-Admin participants, of which 199 (37%) belonged to Sub-Quest. With exposure-risk adjustment based only on administrative indicators, single-dose VE estimates were similar among All-Admin and Sub-Quest populations at 35% (95% confidence interval [CI]:\u22122 to 59) and 30% (95% CI:\u221238 to 64), respectively. With adjustment supplemented by questionnaire information, the Sub-Quest VE estimate increased to 65% (95% CI:1\u201387), with overlapping confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Using only administrative data, we estimate one vaccine dose reduced the mpox risk by about one-third; whereas, additionally adjusting for self-reported risk factor information revealed greater vaccine benefit, with one dose instead estimated to reduce the mpox risk by about two-thirds. Inadequate exposure-risk adjustment may substantially under-estimate mpox VE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciad584","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T15:09:39Z","timestamp":1695913779000},"page":"461-469","source":"Crossref","is-referenced-by-count":19,"title":["Single-dose Effectiveness of Mpox Vaccine in Quebec, Canada: Test-negative Design With and Without Adjustment for Self-reported Exposure Risk"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-3177","authenticated-orcid":false,"given":"Nicholas","family":"Brousseau","sequence":"first","affiliation":[{"name":"Biological Risks Department, Institut national de sant\u00e9 publique du Qu\u00e9bec , Quebec, QC , Canada"},{"name":"Axe Maladies infectieuses et immunitaires, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Center , Quebec, QC , Canada"},{"name":"Social and Preventive Medicine Department, Faculty of Medicine, Laval University , Quebec, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-6703","authenticated-orcid":false,"given":"Sara","family":"Carazo","sequence":"additional","affiliation":[{"name":"Biological Risks Department, Institut national de sant\u00e9 publique du Qu\u00e9bec , Quebec, QC , Canada"},{"name":"Social and Preventive Medicine Department, Faculty of Medicine, Laval University , Quebec, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossi","family":"Febriani","sequence":"additional","affiliation":[{"name":"Axe Maladies infectieuses et immunitaires, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Center , Quebec, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"Padet","sequence":"additional","affiliation":[{"name":"Biological Risks Department, Institut national de sant\u00e9 publique du Qu\u00e9bec , Quebec, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Hegg-Deloye","sequence":"additional","affiliation":[{"name":"Axe Maladies infectieuses et immunitaires, Centre Hospitalier Universitaire (CHU) de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Center , Quebec, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Cadieux","sequence":"additional","affiliation":[{"name":"Direction r\u00e9gionale de sant\u00e9 publique de Montr\u00e9al , Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux du Centre-Sud-de-l'\u00cele-de-Montr\u00e9al, Montreal, QC , Canada"},{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University , Montr\u00e9al, QC , 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Dumont-Blais","sequence":"additional","affiliation":[{"name":"Mpox Awareness Team, R\u00c9ZO Community Organization , Montreal, QC \u00a0 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Bastien","sequence":"additional","affiliation":[{"name":"Mpox Awareness Team, R\u00c9ZO Community Organization , Montreal, QC \u00a0 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Dalp\u00e9","sequence":"additional","affiliation":[{"name":"Biological Risks Department, Institut national de sant\u00e9 publique du Qu\u00e9bec , Quebec, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Henri","family":"Minot","sequence":"additional","affiliation":[{"name":"Biological Risks Department, Institut national de sant\u00e9 publique du Qu\u00e9bec , Quebec, QC , 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