{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:02Z","timestamp":1787008622995,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real-world experience with combinations of short-course rifapentine-based regimens and integrase strand-transfer inhibitor\u2013containing antiretroviral therapy (ART) in management of latent tuberculous infection (LTBI) is limited among people with human immunodeficiency virus (PWH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From August 2019 to October 2022, PWH receiving 3 months of weekly rifapentine plus isoniazid (3HP) or 1 month of daily rifapentine plus isoniazid (1HP) in combination with ART were included. The primary outcome was virologic response within 12 months after LTBI treatment; secondary outcomes included treatment completion rate and safety of LTBI regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 479 PWH (94.6% male; median age, 43 years) were included: 142 received 1HP and bictegravir (BIC)-containing regimens (1HP\/BIC group), 46 1HP and dolutegravir (DTG)-containing regimens (1HP\/DTG group), 38 3HP and BIC-containing regimens (3HP\/BIC group), 214 3HP and DTG-containing regimens (3HP\/DTG group), 17 1HP and other ART regimens (1HP\/others group), and 22 3HP\/other ART regimens (3HP\/others group). In the intention-to-treat analysis, the proportions of PWH maintaining plasma HIV-1 RNA &amp;lt;200\u2005copies\/mL within 12 months after LTBI treatment completion were 96.5% (1HP\/BIC), 100% (1HP\/DTG), 100% (3HP\/BIC), 95.8% (3HP\/DTG), 100% (1HP\/others), and 100% (3HP\/others). The overall completion rates were &amp;gt;80% for all treatment groups, whereas &amp;gt;50% of the included PWH experienced any adverse event. LTBI regimens and ART combinations were not associated with virologic response and completion rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combinations of short-course rifapentine-based regimens and integrase strand-transfer inhibitor-containing ART maintained viral suppression for most PWH within 12 months of LTBI treatment completion with low rates of grade 3 or higher adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciad730","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T12:59:02Z","timestamp":1701781142000},"page":"1295-1303","source":"Crossref","is-referenced-by-count":13,"title":["Treatment Responses to Integrase Strand-transfer Inhibitor-containing Antiretroviral Regimens in Combination With Short-course Rifapentine-based Regimens for Latent Tuberculosis Infection Among People With 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