{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:15:42Z","timestamp":1780683342595,"version":"3.54.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068632"],"award-info":[{"award-number":["UM1AI068632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068616"],"award-info":[{"award-number":["UM1AI068616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI106716"],"award-info":[{"award-number":["UM1AI106716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We evaluated associations between antepartum weight change and adverse pregnancy outcomes and between antiretroviral therapy (ART) regimens and week 50 postpartum body mass index in IMPAACT 2010.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women with human immunodeficiency virus (HIV)-1 in 9 countries were randomized 1:1:1 at 14\u201328 weeks\u2019 gestational age (GA) to start dolutegravir (DTG) + emtricitabine (FTC)\/tenofovir alafenamide fumarate (TAF) versus DTG + FTC\/tenofovir disoproxil fumarate (TDF) versus efavirenz (EFV)\/FTC\/TDF. Insufficient antepartum weight gain was defined using Institute of Medicine guidelines. Cox-proportional hazards regression models were used to evaluate the association between antepartum weight change and adverse pregnancy outcomes: stillbirth (\u226520 weeks\u2019 GA), preterm delivery (&amp;lt;37 weeks\u2019 GA), small size for GA (&amp;lt;10th percentile), and a composite of these endpoints.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 643 participants were randomized: 217 to the DTG + FTC\/TAF, 215 to the DTG + FTC\/TDF, and 211 to the EFV\/FTC\/TDF arm. Baseline medians were as follows: GA, 21.9 weeks; HIV RNA, 903 copies\/mL; and CD4 cell count, 466\/\u03bcL. Insufficient weight gain was least frequent with DTG + FTC\/TAF (15.0%) versus DTG + FTC\/TDF (23.6%) and EFV\/FTC\/TDF (30.4%). Women in the DTG + FTC\/TAF arm had the lowest rate of composite adverse pregnancy outcome. Low antepartum weight gain was associated with higher hazard of composite adverse pregnancy outcome (hazard ratio, 1.44 [95% confidence interval, 1.04\u20132.00]) and small size for GA (1.48 [.99\u20132.22]). More women in the DTG + FTC\/TAF arm had a body mass index \u226525 (calculated as weight in kilograms divided by height in meters squared) at 50 weeks postpartum (54.7%) versus the DTG + FTC\/TDF (45.2%) and EFV\/FTC\/TDF (34.2%) arms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Antepartum weight gain on DTG regimens was protective against adverse pregnancy outcomes typically associated with insufficient weight gain, supportive of guidelines recommending DTG-based ART for women starting ART during pregnancy. Interventions to mitigate postpartum weight gain are needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae001","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T17:46:18Z","timestamp":1704476778000},"page":"1617-1628","source":"Crossref","is-referenced-by-count":10,"title":["Weight Changes and Adverse Pregnancy Outcomes With Dolutegravir- and Tenofovir Alafenamide Fumarate\u2013Containing Antiretroviral Treatment Regimens During Pregnancy and Postpartum"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-4574","authenticated-orcid":false,"given":"Risa M","family":"Hoffman","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California , Los Angeles, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Brummel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T.H. 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