{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:14:24Z","timestamp":1772234064391,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01AI151072"],"award-info":[{"award-number":["5R01AI151072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"CDC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tuberculosis (TB) is a public health threat, with &amp;gt;80% of active TB in the United States occurring due to reactivation of latent TB infection (LTBI). We may be underscreening those with high risk for LTBI and overtesting those at lower risk. A better understanding of gaps in current LTBI testing practices in relation to LTBI test positivity is needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study, conducted between 1 January 2008 and 31 December 2019 at Kaiser Permanente Southern California, included individuals aged \u226518 years without a history of active TB. We examined factors associated with LTBI testing and LTBI positivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 3 816 884 adults (52% female, 37% White, 37% Hispanic, mean age 43.5 years [standard deviation, 16.1]), 706 367 (19%) were tested for LTBI, among whom 60 393 (9%) had \u22651 positive result. Among 1 211 971 individuals who met \u22651 screening criteria for LTBI, 210 025 (17%) were tested for LTBI. Factors associated with higher adjusted odds of testing positive included male sex (1.32; 95% confidence interval, 1.30\u20131.35), Asian\/Pacific Islander (2.78, 2.68\u20132.88), current smoking (1.24, 1.20\u20131.28), diabetes (1.13, 1.09\u20131.16), hepatitis B (1.45, 1.34\u20131.57), hepatitis C (1.54, 1.44\u20131.66), and birth in a country with an elevated TB rate (3.40, 3.31\u20133.49). Despite being risk factors for testing positive for LTBI, none of these factors were associated with higher odds of LTBI testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Current LTBI testing practices may be missing individuals at high risk of LTBI. Additional work is needed to refine and implement screening guidelines that appropriately target testing for those at highest risk for LTBI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae015","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T21:08:38Z","timestamp":1704920918000},"page":"1304-1312","source":"Crossref","is-referenced-by-count":9,"title":["Latent Tuberculosis Infection Testing Practices in a Large US Integrated Healthcare System"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9469-5875","authenticated-orcid":false,"given":"Jennifer H","family":"Ku","sequence":"first","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei X","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Skarbinski","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California , Oakland, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia J","family":"Bruxvoort","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"},{"name":"Department of Epidemiology, University of Alabama at Birmingham , Birmingham, Alabama , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno J","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte C","family":"Spence","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-8476","authenticated-orcid":false,"given":"Sara Y","family":"Tartof","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA"},{"name":"Department of Health Systems Science , Kaiser Permanente Bernard J. 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