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While people with human immunodeficiency virus (HIV; PWH) have a higher risk of proteinuria than people without HIV (PWOH), it is unknown whether incident proteinuria differs by HIV serostatus among prediabetic persons.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The urine protein-to-creatinine ratio was measured at semiannual visits among men in the Multicenter AIDS Cohort Study since April 2006. Men with pre-DM on or after April 2006 and no prevalent proteinuria or use of antidiabetic medications were included. Pre-DM was defined as a fasting glucose level of 100\u2013125\u2005mg\/dL confirmed within a year by a repeated fasting glucose or hemoglobin A1c measurement of 5.7%\u20136.4%. Incident proteinuria was defined as a urine protein-to-creatinine ratio (UPCR) &amp;gt;200\u2005mg\/g, confirmed within a year. We used Poisson regression models to determine whether incident proteinuria in participants with pre-DM differed by HIV serostatus and, among PWH, whether HIV-specific factors were related to incident proteinuria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between 2006 and 2019, among 1276 men with pre-DM, proteinuria developed in 128 of 613 PWH (21%) and 50 of 663 PWOH (8%) over a median 10-year follow-up. After multivariable adjustment, the incidence of proteinuria in PWH with pre-DM was 3.3 times (95% confidence interval, 2.3\u20134.8 times) greater than in PWOH (P &amp;lt; .01). Among PWH, current CD4 cell count &amp;lt;50\/\u00b5L (P &amp;lt; .01) and current use of protease inhibitors (P = .03) were associated with incident proteinuria, while lamivudine and integrase inhibitor use were associated with a lower risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among men with pre-DM, the risk of incident proteinuria was 3 times higher in PWH. Strategies to preserve renal function are needed in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae065","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T17:39:56Z","timestamp":1707500396000},"page":"469-476","source":"Crossref","is-referenced-by-count":1,"title":["Incident Proteinuria by HIV Serostatus Among Men With Pre\u00ad\u2013Diabetes Mellitus: The Multicenter AIDS Cohort Study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-6036","authenticated-orcid":false,"given":"Laurence","family":"Slama","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, APHP, Hotel-Dieu Hospital , Paris , France"},{"name":"University Paris Cit\u00e9 and University Sorbonne Paris Nord, INSERM, INRAE, Center for Research in Epidemiology and StatisticS (CRESS) , Paris , France"},{"name":"Feinberg School of Medicine, Northwestern University , Chicago, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin W","family":"Barrett","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison G","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Colorado School of Public Health , Aurora, Colorado , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Frank J","family":"Palella","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University , Chicago, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared W","family":"Magnani","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania , 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