{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:21:50Z","timestamp":1792070510208,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Murdoch Children's"},{"name":"Research Institute"},{"name":"Child Health Analytics and Informatics Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Intussusception is the primary cause of acute bowel obstruction in infants. The majority of cases &amp;lt;2 years of age are classed as idiopathic, with viral infection implicated as one of the causes. Coronavirus disease 2019 (COVID-19) public health measures led to significant decreases in communicable disease prevalence. During these times, reductions in intussusception frequency were greater than would be expected with our previous understanding of its infectious etiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective, multistate, ecological study over a 12-year period. Monthly case numbers of \u201cintussusception\u201d-coded admissions (code K56.1; International Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification) were acquired from state-wide admissions data sets from New South Wales, Victoria, and Queensland, representing 77.62% of the eligible Australian population. These counts within differing jurisdictional lockdowns were compared with non-lockdown periods in order to investigate a correlation between intussusception frequency and lockdown periods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found a negative association between intussusception frequency and lockdown periods in both eligible states. The largest reductions were seen in the &amp;lt;2-year age groups, with Victoria experiencing a 62.7% reduction (rate ratio, 0.37; P &amp;lt; .001) and New South Wales a 40.1% reduction (0.599; P = .006) during lockdown times. Controls for variations in lockdown restrictions between both regional and metropolitan areas also showed expected decreases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our ecological study demonstrates significant decreases in the frequency of pediatric intussusception admissions during the COVID-19 lockdown periods. The unexpected magnitude of the reductions suggests that the true proportion of infectious disease-caused idiopathic intussusception is greatly underestimated.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae084","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T16:59:00Z","timestamp":1708448340000},"page":"255-262","source":"Crossref","is-referenced-by-count":7,"title":["Exploring the Infectious Contribution to Intussusception Causality Using the Effects of COVID-19 Lockdowns in Australia: An Ecological Study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1625-1759","authenticated-orcid":false,"given":"Benjamin","family":"Townley","sequence":"first","affiliation":[{"name":"Child Health Analytics and Informatics Research, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"School of Medicine, Monash University , Clayton, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Akin","sequence":"additional","affiliation":[{"name":"Child Health Analytics and Informatics Research, Murdoch Children's Research Institute , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo Luis","family":"Dimaguila","sequence":"additional","affiliation":[{"name":"Child Health Analytics and Informatics Research, Murdoch Children's Research Institute , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Sawires","sequence":"additional","affiliation":[{"name":"Child Health Analytics and Informatics Research, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"School of Medicine, Monash University , Clayton, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Sepulveda Kattan","sequence":"additional","affiliation":[{"name":"Child Health Analytics and Informatics Research, Murdoch Children's Research Institute , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-0265","authenticated-orcid":false,"given":"Sebastian","family":"King","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"Department of Pediatric Surgery, Royal Children's Hospital , Parkville, Victoria , Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-6601","authenticated-orcid":false,"given":"Julie","family":"Bines","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia"},{"name":"Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital , Parkville, Victoria , Australia"},{"name":"Enteric Diseases, Murdoch Children's Research Institute , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Wood","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance, Sydney Children's Hospital Network , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-193X","authenticated-orcid":false,"given":"Stephen","family":"Lambert","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance, Sydney Children's Hospital Network , Sydney, New South Wales , Australia"},{"name":"Communicable Diseases Branch, Queensland Health , Brisbane, Queensland , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-2035","authenticated-orcid":false,"given":"Jim","family":"Buttery","sequence":"additional","affiliation":[{"name":"Child Health Analytics and Informatics Research, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"Department of Paediatrics, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia"},{"name":"Infectious Diseases Unit, Royal Children's Hospital , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"2024071918134501600_ciae084-B1","volume-title":"Acute intussusception in infants and children: incidence, clinical representation and management : a global perspective","author":"World Health 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Int"},{"key":"2024071918134501600_ciae084-B8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/pgmj.2004.022749","article-title":"Adult intussusception: case reports and review of literature","volume":"81","author":"Yalamarthi","year":"2005","journal-title":"Postgrad Med J"},{"key":"2024071918134501600_ciae084-B9","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jpeds.2006.04.010","article-title":"Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus","volume":"149","author":"Bines","year":"2006","journal-title":"J Pediatrics"},{"key":"2024071918134501600_ciae084-B10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1651-2227.2012.02616.x","article-title":"Simultaneous presence of human herpesvirus 6 and adenovirus infections in intestinal intussusception of young children","volume":"101","author":"Lappalainen","year":"2012","journal-title":"Acta 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