{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:49:53Z","timestamp":1787759393255,"version":"build-2784847793"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC \u03b2-lactamase\u2013producing Enterobacterales, species with low in vitro mutation rates for AmpC derepression were associated with fewer treatment failures due to AmpC overproduction (adjusted hazard ratio, 0.5 [95% CI, .2\u2013.9]). However, compared to cefepime\/carbapenems, using third-generation cephalosporins as definitive therapy remained associated with this adverse outcome (15% vs 1%).<\/jats:p>","DOI":"10.1093\/cid\/ciae160","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:53:11Z","timestamp":1711417991000},"page":"52-55","source":"Crossref","is-referenced-by-count":10,"title":["Mutation Rate of AmpC \u03b2-Lactamase\u2013Producing Enterobacterales and Treatment in Clinical Practice: A Word of Caution"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-4103","authenticated-orcid":false,"given":"Alexis","family":"Maillard","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Dortet","sequence":"additional","affiliation":[{"name":"Department of Bacteriology-Hygiene, Bic\u00eatre Hospital, AP-HP , Le Kremlin-Bic\u00eatre , France"},{"name":"Faculty of Medicine, UMR-1184, Inserm, University Paris-Saclay , Le Kremlin-Bic\u00eatre , France"},{"name":"French National Reference Center for Antimicrobial Resistance , Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Delory","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Annecy-Genevois Hospital , Epagny-Metz-Tessy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Lafaurie","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Saint-Louis Hospital, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bleibtreu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 , Paris , France"},{"name":"Inserm U1135, Cimi-Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Treatment of AmpC producing Enterobacterales study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Lafaurie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Bercot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Paccoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bleibtreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Drieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Maury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Surgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Chopin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lalande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Tankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Delory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Contejean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Poupet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Baillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9lia","family":"Escaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Jaureguiberry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Cuzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Dortet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Chaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"El Alaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Ralph","family":"Zahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"2024071918111304700_ciae160-B1","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/cid\/ciz173","article-title":"A primer on AmpC \u03b2-lactamases: necessary knowledge for an increasingly multidrug-resistant world","volume":"69","author":"Tamma","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2024071918111304700_ciae160-B2","doi-asserted-by":"crossref","first-page":"105834","DOI":"10.1016\/j.ijantimicag.2019.10.015","article-title":"Infections caused by naturally AmpC-producing Enterobacteriaceae: can we use third-generation cephalosporins? A narrative review","volume":"55","author":"Mizrahi","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"2024071918111304700_ciae160-B3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jcrc.2019.11.005","article-title":"Piperacillin-tazobactam should be preferred to third-generation cephalosporins to treat wild-type inducible AmpC-producing Enterobacterales in critically ill patients with hospital or ventilator-acquired pneumonia","volume":"56","author":"Carri\u00e9","year":"2020","journal-title":"J Crit Care"},{"key":"2024071918111304700_ciae160-B4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13054-024-04820-7","article-title":"Antibiotic definitive treatment in ventilator associated pneumonia caused by AmpC-producing Enterobacterales in critically ill patients: a prospective multicenter observational study","volume":"28","author":"Petit","year":"2024","journal-title":"Crit Care"},{"key":"2024071918111304700_ciae160-B5","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/jac\/dky084","article-title":"Species-specific mutation rates for ampC derepression in Enterobacterales with chromosomally encoded inducible AmpC \u03b2-lactamase","volume":"73","author":"Kohlmann","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2024071918111304700_ciae160-B6","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/cid\/ciab1013","article-title":"Infectious Diseases Society of America guidance on the treatment of AmpC \u03b2-lactamase\u2013producing Enterobacterales, carbapenem-resistant Acinetobacter baumannii, and Stenotrophomonas maltophilia infections","volume":"74","author":"Tamma","year":"2022","journal-title":"Clin Infect Dis"},{"key":"2024071918111304700_ciae160-B7","doi-asserted-by":"crossref","first-page":"106809","DOI":"10.1016\/j.ijantimicag.2023.106809","article-title":"Effectiveness of third-generation cephalosporins or piperacillin compared with cefepime or carbapenems for severe infections caused by wild-type AmpC \u03b2-lactamase-producing Enterobacterales: a multi-centre retrospective propensity-weighted study","volume":"62","author":"Maillard","year":"2023","journal-title":"Int J Antimicrob Agents"},{"key":"2024071918111304700_ciae160-B8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.medmal.2010.10.001","article-title":"Antibioth\u00e9rapie par voie g\u00e9n\u00e9rale dans les infections respiratoires basses de l\u2019adulte. Pneumonie aigu\u00eb communautaire. Exacerbations de bronchopneumopathie chronique obstructive","volume":"41","author":"Chidiac","year":"2011","journal-title":"M\u00e9decine Mal Infect"},{"key":"2024071918111304700_ciae160-B9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.anrea.2018.07.003","article-title":"Pneumonies associ\u00e9es aux soins de r\u00e9animation","volume":"4","author":"Leone","year":"2018","journal-title":"Anesth R\u00e9animation"},{"key":"2024071918111304700_ciae160-B10","author":"European Committee on Antimicrobial Susceptibility Testing."},{"key":"2024071918111304700_ciae160-B11","author":"Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie"},{"key":"2024071918111304700_ciae160-B12","doi-asserted-by":"crossref","first-page":"ofab387","DOI":"10.1093\/ofid\/ofab387","article-title":"Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections caused by AmpC \u03b2-lactamase-producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: a pilot multicenter randomized controlled trial (MERINO-2)","volume":"8","author":"Stewart","year":"2021","journal-title":"Open Forum Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciae160\/57505902\/ciae160.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/79\/1\/52\/58599884\/ciae160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/79\/1\/52\/58599884\/ciae160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T18:11:43Z","timestamp":1721412703000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/79\/1\/52\/7634798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3,25]]},"published-print":{"date-parts":[[2024,7,19]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciae160","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7,15]]},"published":{"date-parts":[[2024,3,25]]}}}