{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:58:14Z","timestamp":1790740694801,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Streptococcal bacteremia is associated with high mortality. Thia study aims to identify predictors of mortality among patients with streptococcal bacteremia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study was conducted at the Lausanne University Hospital, Switzerland, and included episodes of streptococcal bacteremia among adult patients from 2015 to 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the study period, 861 episodes of streptococcal bacteremia were included. The majority of episodes were categorized in the Mitis group (348 episodes; 40%), followed by the Pyogenic group (215; 25%). Endocarditis was the most common source of bacteremia (164; 19%). The overall 14-day mortality rate was 8% (65 episodes). The results from the Cox multivariable regression model showed that a Charlson comorbidity index &amp;gt;4 (P .001; hazard ratio [HR], 2.87; confidence interval [CI]: 1.58\u20135.22), Streptococcus pyogenes (P = .011; HR, 2.54;CI: 1.24\u20135.21), sepsis (P &amp;lt; .001; HR, 7.48; CI: 3.86\u201314.47), lower respiratory tract infection (P = .002; HR, 2.62; CI: 1.42\u20134.81), and absence of source control interventions within 48 hours despite being warranted (P = .002; HR, 2.62; CI: 1.43\u20134.80) were associated with 14-day mortality. Conversely, interventions performed within 48\u2005hours of bacteremia onset, such as infectious diseases consultation (P &amp;lt; .001; HR, 0.29; CI: .17\u2013.48) and appropriate antimicrobial treatment (P &amp;lt; .001; HR, .28; CI: .14\u2013.57), were associated with improved outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings underscore the pivotal role of infectious diseases consultation in guiding antimicrobial treatment and recommending source control interventions for patients with streptococcal bacteremia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae168","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T10:45:27Z","timestamp":1711363527000},"page":"1544-1550","source":"Crossref","is-referenced-by-count":21,"title":["Predictors of Mortality of Streptococcal Bacteremia and the Role of Infectious 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