{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:09:08Z","timestamp":1740128948219,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"U.S. National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI095041"],"award-info":[{"award-number":["R01AI095041"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. National Institute of Mental Health","doi-asserted-by":"publisher","award":["F31MH121128"],"award-info":[{"award-number":["F31MH121128"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tuberculosis (TB) preventive therapy (TPT) reduces the risk of TB disease in people with human immunodeficiency virus (HIV), yet uptake has been suboptimal in many countries. We assessed whether QuantiFERON Gold In-Tube (QGIT) during routine HIV care increased TB infection (TBI) testing and TPT prescriptions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This parallel-arm, 1:1 cluster-randomized controlled trial compared the standard-of-care tuberculin skin test to QGIT in South Africa. We enrolled consenting, TPT-eligible adults diagnosed with HIV \u226430 days prior and used intention-to-treat analyses for the outcomes: proportion of patients with documented TBI results, proportion with documented TPT, and time from enrollment to outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Findings<\/jats:title>\n                  <jats:p>We enrolled 2232 patients across 14 clinics from November 2014 to May 2017 (58% in intervention clinics). At 24 months of follow-up, more participants in intervention clinics had TBI results (69% vs 2%, P &amp;lt; .001) and TPT prescriptions (45% vs 30%, P = .13) than control clinics. Controlling for baseline covariates, intervention clinics had 60% (95% confidence interval, 51\u201368; P &amp;lt; .001) more participants with TBI results and 12% (95% confidence interval, \u22126 to 31; P = .18) more with TPT prescriptions. Among participants with results, those in intervention clinics received results and TPT faster (intervention: median of 6 and 29 days after enrollment vs control: 21 and 54 days, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interpretation<\/jats:title>\n                  <jats:p>In this setting, QGIT in routine HIV care resulted in more patients with TBI results. Clinicians also initiated more people with HIV on TPT in QGIT intervention clinics, and did so more quickly, than the control arm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT02119130.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae268","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T09:34:49Z","timestamp":1721640889000},"page":"751-760","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of QuantiFERON Gold In-Tube Versus Tuberculin Skin Tests on the Initiation of Tuberculosis Preventive Therapy Among Patients Newly Diagnosed With HIV in the North West Province of South Africa (the Teko Study): A Cluster Randomized Trial"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-3521","authenticated-orcid":false,"given":"Brooke A","family":"Jarrett","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Shearer","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine , Baltimore Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katlego","family":"Motlhaoleng","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit, The University of the Witwatersrand , Soweto ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Chon","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine , Baltimore Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaolaolwe Gabriel","family":"Letuba","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit, The University of the Witwatersrand , Soweto ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cokiswa","family":"Qomfo","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit, The University of the Witwatersrand , Soweto ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence H","family":"Moulton","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine , Baltimore Maryland ,","place":["USA"]},{"name":"Department of International Health, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cohn","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine , Baltimore Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limakatso","family":"Lebina","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit, The University of the Witwatersrand , Soweto ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E","family":"Chaisson","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine , Baltimore Maryland ,","place":["USA"]},{"name":"Department of International Health, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebrahim","family":"Variava","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Klerksdorp\u2013Tshepong Hospital Complex , Klerksdorp ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil A","family":"Martinson","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine , Baltimore Maryland ,","place":["USA"]},{"name":"Perinatal HIV Research Unit, The University of the Witwatersrand , Soweto ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan E","family":"Golub","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]},{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine , Baltimore Maryland ,","place":["USA"]},{"name":"Department of International Health, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"author":"Republic of South Africa's Department of Statistics","key":"2024092615372929400_ciae268-B1"},{"key":"2024092615372929400_ciae268-B2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1186\/s12879-016-1989-x","article-title":"Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study","volume":"16","author":"Ncayiyana","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2024092615372929400_ciae268-B3","doi-asserted-by":"crossref","first-page":"e47072","DOI":"10.1371\/journal.pone.0047072","article-title":"Smoking, BCG and employment and the risk of 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