{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:26:57Z","timestamp":1791973617991,"version":"4.4.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Int\u00e9ressement Recherche Saint-Louis"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In burn patients, skin barrier disruption and immune dysfunctions increase susceptibility to invasive fungal diseases (IFDs) like invasive candidiasis (IC) and invasive mold infections (IMI). We provide an in-depth analysis of IFD-related factors and outcomes in a 10-year cohort of severe burn patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study includes adult patients admitted to the burn intensive care unit (BICU) between April 2014 and May 2023 with total burn surface area (TBSA) \u226515%. Patients were classified as proven IFD according to EORTC\/MSGERC criteria applicable for IC. Putative IMIs were defined with: \u22652 positive cultures from a skin biopsy\/bronchoalveolar lavage or \u22652 positive blood specific-quantitative polymerase chain reactions (qPCRs) or a combination of both.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 1381 patients admitted, 276 consecutive patients with TBSA \u226515% were included. Eighty-seven (31.5%; IC n = 30; IMI n = 43; both n = 14) patients fulfilled the criteria for probable\/putative IFD. At Day 30 after the burn injury, the estimated cumulative incidence proven\/putative (pr\/pu) IFD was 26.4% (95% confidence interval [CI], 21.4%\u201331.8%). Factors independently associated with IFDs were TBSA, severity scores and indoor burn injury (ie, from confined space fire). Overall mortality was 15.3% and 36.8% in the no IFD, pr\/pu IFD groups respectively (P &amp;lt; .0001). IFD was independently associated with a risk of death (hazard ratio [HR]: 1.94 for pr\/pu IFD; 95% CI, 1.12\u20133.36; P = .019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study describes twenty-first-century characteristics of IFDs in severe burn patients confirming known risk factors with thresholds and identifying the indoor injury as an independent factor associated to IFDs. This suggests a link to contamination caused by fire damage, which is highly susceptible to aerosolizing spores.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae337","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T16:18:39Z","timestamp":1719332319000},"page":"682-689","source":"Crossref","is-referenced-by-count":19,"title":["Risk Factors and Outcome Associated With Fungal Infections in Patients With Severe Burn Injury: 10-year Retrospective IFI-BURN Study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-4889","authenticated-orcid":false,"given":"Emmanuel","family":"Dudoignon","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care and Burn Unit, Saint-Louis-Lariboisi\u00e8re Hospital, Universit\u00e9 Paris-Cit\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMR-S 942 Mascot, Lariboisi\u00e8re Hospital , Paris ,","place":["France"]},{"name":"FHU PROMICE , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chevret","sequence":"additional","affiliation":[{"name":"Biostatistics Department, Saint Louis Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Paris-Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorel","family":"Tsague","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care and Burn Unit, Saint-Louis-Lariboisi\u00e8re Hospital, Universit\u00e9 Paris-Cit\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Hamane","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology Department, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Saint-Louis Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Chaouat","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care and Burn Unit, Saint-Louis-Lariboisi\u00e8re Hospital, Universit\u00e9 Paris-Cit\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Plastic Surgery Department, Saint-Louis Hospital, Assistance Publique- H\u00f4pitaux de Paris , Universit\u00e9 Paris Cit\u00e9, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Plaud","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care and Burn Unit, Saint-Louis-Lariboisi\u00e8re Hospital, Universit\u00e9 Paris-Cit\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 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