{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:36:40Z","timestamp":1792647400057,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prosthetic joint infection (PJI) caused by Candida spp is a severe complication of arthroplasty. We investigated the outcomes of Candida PJI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective observational multinational study including patients diagnosed with Candida-related PJI between 2010 and 2021. Treatment outcome was assessed at 2-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 269 patients were analyzed. Median age was 73.0 (interquartile range [IQR], 64.0\u201379.0) years; 46.5% of patients were male and 10.8% were immunosuppressed. Main infection sites were hip (53.0%) and knee (43.1%), and 33.8% patients had fistulas. Surgical procedures included debridement, antibiotics, and implant retention (DAIR) (35.7%), 1-stage exchange (28.3%), and 2-stage exchange (29.0%). Candida spp identified were Candida albicans (55.8%), Candida parapsilosis (29.4%), Candida glabrata (7.8%), and Candida tropicalis (5.6%). Coinfection with bacteria was found in 51.3% of cases. The primary antifungal agents prescribed were azoles (75.8%) and echinocandins (30.9%), administered for a median of 92.0 (IQR, 54.5\u2013181.3) days. Cure was observed in 156 of 269 (58.0%) cases. Treatment failure was associated with age &amp;gt;70 years (OR, 1.811 [95% confidence interval {CI}: 1.079\u20133.072]), and the use of DAIR (OR, 1.946 [95% CI: 1.157\u20133.285]). Candida parapsilosis infection was associated with better outcome (OR, 0.546 [95% CI: .305\u2013.958]). Cure rates were significantly different between DAIR versus 1-stage exchange (46.9% vs 67.1%, P = .008) and DAIR versus 2-stage exchange (46.9% vs 69.2%, P = .003), but there was no difference comparing 1- to 2-stage exchanges (P = .777).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Candida PJI prognosis seems poor, with high rate of failure, which does not appear to be linked to immunosuppression, use of azoles, or treatment duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciae395","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T17:35:35Z","timestamp":1722274535000},"page":"347-355","source":"Crossref","is-referenced-by-count":27,"title":["Prosthetic Joint Infections due to\n                    <i>Candida<\/i>\n                    Species: A Multicenter International Study"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-4819","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Dinh","sequence":"first","affiliation":[{"name":"Infectious Disease Department, Raymond-Poincar\u00e9 University Hospital, Paris Saclay University, Assistance Publique-H\u00f4pitaux de Paris , Garches ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"McNally","sequence":"additional","affiliation":[{"name":"Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals , Oxford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"D\u2019Anglejan","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Raymond-Poincar\u00e9 University Hospital, Paris Saclay University, Assistance Publique-H\u00f4pitaux de Paris , Garches 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