{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:54:57Z","timestamp":1794246897617,"version":"4.9.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100003024","name":"International Cohort Consortium of Infectious Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CHU St Pierre Brussels HIV Cohort","award":["U01-AI069907"],"award-info":[{"award-number":["U01-AI069907"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["GNT2023845"],"award-info":[{"award-number":["GNT2023845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With integrase strand transfer inhibitor (INSTI) use associated with increased body mass index (BMI) and BMI increases associated with higher diabetes mellitus (DM) risk, we explored the relationships between INSTI\/non-INSTI regimens, BMI changes, and DM risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RESPOND participants were included if they had CD4, human immunodeficiency virus (HIV) RNA, and \u22652 BMI measurements during follow-up. Those with prior DM were excluded. DM was defined as a random blood glucose \u226511.1\u2005mmol\/L, hemoglobin A1c \u22656.5%\/48\u2005mmol\/mol, use of antidiabetic medication, or site-reported clinical diagnosis. Poisson regression was used to assess the association between natural log (ln) of time-updated BMI and current INSTI\/non-INSTI and their interactions on DM risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 20 865 people with HIV included, most were male (74%) and White (73%). Baseline median age was 45 years (interquartile range [IQR], 37\u201352), with a median BMI of 24\u2005kg\/m2 (IQR, 22\u201326). There were 785 DM diagnoses with a crude rate of 0.73 (95% confidence interval [CI], .68\u2013.78)\/100 person-years of follow-up. ln(BMI) was strongly associated with DM (adjusted incidence rate ratio [aIRR], 16.54 per log increase; 95% CI, 11.33\u201324.13; P &amp;lt; .001). Current INSTI use was associated with increased DM risk (IRR, 1.58; 95% CI, 1.37\u20131.82; P &amp;lt; .001) in univariate analyses and only partially attenuated when adjusted for variables including ln(BMI) (aIRR, 1.48; 95% CI, 1.29\u20131.71; P &amp;lt; .001). There were no interactions between ln(BMI), INSTI, and non-INSTI use and DM (P = .130).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In RESPOND, compared with non-INSTIs, current use of INSTIs was associated with an increased DM risk, which partially attenuated when adjusted for BMI changes and other variables.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciae406","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T22:44:43Z","timestamp":1723157083000},"page":"404-416","source":"Crossref","is-referenced-by-count":37,"title":["Integrase Strand Transfer Inhibitor\u2013Related Changes in Body Mass Index and Risk of Diabetes: A Prospective Study From the RESPOND Cohort 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,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zangerle","sequence":"additional","affiliation":[{"name":"Austrian HIV Cohort Study, Medizinische Universit\u00e4t Innsbruck , Innsbruch ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andri","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E","family":"Tarr","sequence":"additional","affiliation":[{"name":"Swiss HIV Cohort Study, University Department of Medicine, Kantonsspital Baselland, University of Basel , Bruderholz ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, Epidemiology, 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