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We evaluated metabolic markers in pregnant women with human immunodeficiency virus (HIV) after starting TAF- versus TDF-based ART.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed data within the IMPAACT 2010\/VESTED trial, which demonstrated better pregnancy outcomes in pregnant women randomized to initiate TAF\/Emtricitabine\/Dolutegravir (TAF\/FTC + DTG; n = 217) or TDF\/FTC + DTG (n = 215). We measured non-fasting plasma concentrations of glucose, total-cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), lipoprotein (a), and triglycerides from samples collected 8 weeks after enrollment. We employed linear regression models to estimate by-arm mean differences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 219 participants enrolled in the DTG arms in Zimbabwe and Uganda: 109 in the TAF\/FTC + DTG and 110 in the TDF\/FTC + DTG arms. At study entry, mean gestational age was 22.6 weeks, median HIV-1 RNA was 711 copies\/mL, and mean age was 25.8 years. By 8 weeks, mean total cholesterol was 12\u2005mg\/dL higher in women randomized to TAF\/ FTC + DTG versus TDF\/FTC + DTG (95% confidence interval [CI]: 3.8, 21.1). Pregnant women in the TAF\/FTC + DTG arm had higher mean LDL-C (7.1\u2005mg\/dL, 95% CI: .2, 14.0), triglycerides (12.3\u2005mg\/dL, 95% CI: 1.8, 22.7), lipoprotein (a) (7.3\u2005mg\/dL, 95% CI: 1.1, 13.6), and lower mean HDL-C (2.8\u2005mg\/dL, 95% CI: .1, 5.6) compared to the TDF\/FTC + DTG arm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Pregnant women randomized to start TAF\/FTC + DTG had higher lipids than those randomized to TDF\/FTC + DTG within 8 weeks of ART initiation. However, lipid levels were within normal reference ranges.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae441","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T12:34:06Z","timestamp":1725280446000},"page":"594-601","source":"Crossref","is-referenced-by-count":6,"title":["Lipid and Glucose Profiles in Pregnant Women With HIV on Tenofovir-based Antiretroviral Therapy"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-9840","authenticated-orcid":false,"given":"Ahizechukwu C","family":"Eke","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean S","family":"Brummel","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. 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