{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:21:25Z","timestamp":1758403285045,"version":"3.40.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01443","CM23\/00255","CM22\/00176"],"award-info":[{"award-number":["PI19\/01443","CM23\/00255","CM22\/00176"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gilead Biomedical Research Fellowship Program","award":["GLD21_00096"],"award-info":[{"award-number":["GLD21_00096"]}]},{"name":"GEHEP-SEIMC"},{"name":"Unidades Cl\u00ednicas del Servicio Andaluz de Salud 2021"},{"name":"Cl\u00ednicos Investigadores","award":["B-0061-2021","JR23\/00066","A1-0060-2021"],"award-info":[{"award-number":["B-0061-2021","JR23\/00066","A1-0060-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In patients with hepatitis C virus (HCV) chronic infection and advanced liver disease, the impact of human immunodeficiency virus (HIV) coinfection on the clinical outcome after sustained virological response (SVR) has not been sufficiently clarified. The aim of this study was to compare the mortality after SVR of patients bearing HCV chronic infection and advanced liver fibrosis, with and without HIV coinfection after a prolonged follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective multicenter cohort study including individuals with HIV\/HCV coinfection and patients with HCV monoinfection from Spain, fulfilling (1) liver stiffness (LS) \u22659.5\u2005kPa before treatment, (2) SVR with a direct-acting antiviral\u2013based regimen, and (3) LS measurement available at SVR. The main outcome was overall survival. Mortality attributable to liver disease and nonhepatic causes was also assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1118 patients were included, of whom 676 (60.5%) had HIV. The median (Q1\u2013Q3) follow-up was 76 (57\u201383) months. After SVR, 46 (10%) HCV-monoinfected and 74 (11%) HIV\/HCV-coinfected patients died. The overall mortality rate (95% CI) was 1.9 (1.6\u20132.2) per 100 person-years, 1.9 (1.4\u20132.5) per 100 person-years in patients with HCV monoinfection, and 1.8 (1.6\u20132.3) per 100 person-years in people with HIV. In the multivariable analysis, HIV coinfection was not associated with shorter survival (hazard ratio, .98; 95% CI, .61\u20131.58; P = .939).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with HCV chronic infection and advanced fibrosis, HIV coinfection does not reduce the overall survival after SVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>Clinicaltrials.gov (NCT04460157).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae473","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T20:31:45Z","timestamp":1726518705000},"page":"835-841","source":"Crossref","is-referenced-by-count":2,"title":["No Impact of HIV Coinfection on Mortality in Patients With Hepatitis C Virus Infection After Sustained Virological Response"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-4745","authenticated-orcid":false,"given":"Jesica","family":"Mart\u00edn-Carmona","sequence":"first","affiliation":[{"name":"Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme , Seville ,","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla (IBiS)\/CSIC , Seville ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Universidad de Sevilla (US) , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-0237","authenticated-orcid":false,"given":"Ana\u00efs","family":"Corma-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme , Seville ,","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla (IBiS)\/CSIC , Seville ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"T\u00e9llez","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario de Puerto Real, Faculty of Medicine, Universidad de C\u00e1diz , C\u00e1diz ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Arenga-Barrios","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario de Puerto Real, Faculty of Medicine, Universidad de C\u00e1diz , C\u00e1diz ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Serrano-Fuentes","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario de Gran Canaria Dr Negr\u00edn , Las Palmas de Gran Canaria ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Morano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario Alvaro Cunqueiro , Vigo ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IISGS) , Vigo ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Corona-Mata","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Clinical Virology and Zoonoses Research Group, Unit of Infectious Diseases, Hospital Universitario Reina Sof\u00eda , C\u00f3rdoba ,","place":["Spain"]},{"name":"Department of Medicine, Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) , C\u00f3rdoba ,","place":["Spain"]},{"name":"Department of Medicine, Universidad de C\u00f3rdoba (UCO) , C\u00f3rdoba ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Nicol\u00e1s","family":"Navarrete Lorite","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario Virgen Macarena , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Jes\u00fas","family":"Vera-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Section of Infectious Medicine\/Service of Internal Medicine, Hospital General Universitario Santa Luc\u00eda , Cartagena ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Alados","sequence":"additional","affiliation":[{"name":"Unit of Clinical Microbiology, University Hospital Jerez , Cadiz ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Palacios","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Hospital Virgen de la Victoria , M\u00e1laga ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"de los Santos","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Unit of Internal Medicine and Infectious Diseases, Hospital La Princesa , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Geijo","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Hospital General Virgen de la Luz , Cuenca ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkaitz","family":"Imaz","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario Bellvitge , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Merino","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Hospital Universitario Juan Ram\u00f3n Jimenez , Huelva ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Javier","family":"Reus-Ba\u00f1uls","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hospital General Universitario de Alicante , Alicante ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jose","family":"Galindo","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hospital Cl\u00ednico Universitario de Valencia , Valencia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"L\u00f3pez-Ruz","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Internal Medicine Service, Virgen de las Nieves University Hospital , Granada ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Galera","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca , Murcia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A","family":"Pineda","sequence":"additional","affiliation":[{"name":"Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme , Seville ,","place":["Spain"]},{"name":"Universidad de Sevilla (US) , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme , Seville ,","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla (IBiS)\/CSIC , Seville ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Universidad de Sevilla (US) , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"2025043020394994600_ciae473-B1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(18)32111-1","article-title":"Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study","volume":"393","author":"Carrat","year":"2019","journal-title":"Lancet"},{"key":"2025043020394994600_ciae473-B2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1053\/j.gastro.2016.09.009","article-title":"Eradication of hepatitis C virus infection in patients with cirrhosis reduces risk of liver and non-liver complications","volume":"152","author":"Nahon","year":"2017","journal-title":"Gastroenterology"},{"key":"2025043020394994600_ciae473-B3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1097\/QAD.0000000000002186","article-title":"HIV infection does not increase the risk of liver complications in hepatitis C virus-infected patient with advanced fibrosis, after sustained virological response with direct-acting antivirals","volume":"33","author":"Corma-G\u00f3mez","year":"2019","journal-title":"AIDS"},{"key":"2025043020394994600_ciae473-B4","doi-asserted-by":"crossref","first-page":"e2109","DOI":"10.1093\/cid\/ciaa1111","article-title":"Human immunodeficiency virus (HIV) infection is associated with lower risk of hepatocellular carcinoma after sustained virological response to direct-acting antivirals in hepatitis C infected patients with advanced fibrosis","volume":"73","author":"Corma-G\u00f3mez","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2025043020394994600_ciae473-B5","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1097\/QAD.0000000000002959","article-title":"Kinetics of emergence of liver complications in hepatitis C virus infected patients and advanced fibrosis, with and without HIV-coinfection, after sustained virological response","volume":"35","author":"Corma-G\u00f3mez","year":"2021","journal-title":"AIDS"},{"key":"2025043020394994600_ciae473-B6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/cid\/ciw683","article-title":"Persistent, albeit reduced, chronic inflammation in persons starting antiretroviral therapy in acute HIV infection","volume":"64","author":"Sereti","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2025043020394994600_ciae473-B7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/cid\/ciw697","article-title":"Very early ART and persistent inflammation in treated HIV","volume":"64","author":"Hunt","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2025043020394994600_ciae473-B8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.24875\/AIDSRev.21000085","article-title":"HIV and aging, biological mechanisms, and therapies: what do we know?","volume":"24","author":"Grosso","year":"2022","journal-title":"AIDS Rev"},{"key":"2025043020394994600_ciae473-B9","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/hep.23136","article-title":"Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus\/hepatitis C virus","volume":"50","author":"Mac\u00edas","year":"2009","journal-title":"Hepatology"},{"key":"2025043020394994600_ciae473-B10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11904-017-0351-2","article-title":"Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in HIV","volume":"14","author":"Rockstroh","year":"2017","journal-title":"Curr HIV\/AIDS Rep"},{"key":"2025043020394994600_ciae473-B11","doi-asserted-by":"crossref","first-page":"e207954","DOI":"10.1001\/jamanetworkopen.2020.7954","article-title":"Comparison of overall and comorbidity-free life expectancy between insured adults with and without HIV infection, 2000\u20132016","volume":"3","author":"Marcus","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2025043020394994600_ciae473-B12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/cid\/ciad671","article-title":"Measures of longitudinal immune dysfunction and risk of AIDS and non-AIDS defining malignancies in antiretroviral-treated people with human immunodeficiency virus","volume":"78","author":"Chammartin","year":"2024","journal-title":"Clin Infect Dis"},{"key":"2025043020394994600_ciae473-B13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jhep.2020.08.008","article-title":"Increased mortality in HIV\/HCV-coinfected compared to HCV-monoinfected patients in the DAA era due to non-liver-related death","volume":"74","author":"Chalouni","year":"2021","journal-title":"J Hepatol"},{"key":"2025043020394994600_ciae473-B14","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/hep.30400","article-title":"Human immunodeficiency virus\/hepatitis C virus (HCV) co-infected patients with cirrhosis are no longer at higher risk for hepatocellular carcinoma or end-stage liver disease as compared to HCV mono-infected patients","volume":"70","author":"Salmon-Ceron","year":"2019","journal-title":"Hepatology"},{"key":"2025043020394994600_ciae473-B15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/hiv.13153","article-title":"Direct, indirect and total effect of HIV coinfection on the risk of non-liver-related cancer in hepatitis C virus-infected patients treated by direct-acting antivirals: a mediation analysis","volume":"22","author":"Chalouni","year":"2021","journal-title":"HIV Med"},{"key":"2025043020394994600_ciae473-B16","doi-asserted-by":"crossref","first-page":"ofad115","DOI":"10.1093\/ofid\/ofad115","article-title":"Adverse impact of HIV-1 on long-term outcomes following HCV DAA treatment: final results of ACTG A5320, the Viral Hepatitis C Infection Long-term Cohort Study (VHICS)","volume":"10","author":"Wyles","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"2025043020394994600_ciae473-B17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/cid\/cit768","article-title":"Prediction of liver complications in patients with hepatitis C virus-related cirrhosis with and without HIV coinfection: comparison of hepatic venous pressure gradient and transient elastography","volume":"58","author":"P\u00e9rez-Latorre","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2025043020394994600_ciae473-B18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.eimc.2012.12.004","article-title":"Sustained virological response to pegylated interferon plus ribavirin leads to normalization of liver stiffness in hepatitis C virus-infected patients","volume":"31","author":"Mac\u00edas","year":"2013","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"2025043020394994600_ciae473-B19","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1093\/jac\/dkq272","article-title":"Changes in liver stiffness in patients with chronic hepatitis C with and without HIV co-infection treated with pegylated interferon plus ribavirin","volume":"65","author":"Mac\u00edas","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"2025043020394994600_ciae473-B20","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.jhep.2016.07.039","article-title":"Reversion of disease manifestations after HCV eradication","volume":"65","author":"van der Meer","year":"2016","journal-title":"J Hepatol"},{"key":"2025043020394994600_ciae473-B21","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1016\/S2352-3018(23)00028-0","article-title":"Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies","volume":"10","author":"Trickey","year":"2023","journal-title":"Lancet HIV"},{"key":"2025043020394994600_ciae473-B22","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000838","article-title":"Clinical outcomes and prognostic factors after HCV clearance with DAA in HIV\/HCV-coinfected patients with advanced fibrosis\/cirrhosis [manuscript published online ahead of print 7 March 2024]","author":"Berenguer","journal-title":"Hepatology"},{"key":"2025043020394994600_ciae473-B23","doi-asserted-by":"crossref","first-page":"ofae239","DOI":"10.1093\/ofid\/ofae239","article-title":"Frequent disengagement and subsequent mortality among people with HIV and hepatitis C in Canada: a prospective cohort study","volume":"11","author":"Saeed","year":"2024","journal-title":"Open Forum Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciae473\/59961916\/ciae473.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/80\/4\/835\/59961916\/ciae473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/80\/4\/835\/59961916\/ciae473.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:39:55Z","timestamp":1746059995000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/80\/4\/835\/7760359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,9,18]]},"published-print":{"date-parts":[[2025,4,30]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciae473","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"type":"print","value":"1058-4838"},{"type":"electronic","value":"1537-6591"}],"subject":[],"published-other":{"date-parts":[[2025,4,15]]},"published":{"date-parts":[[2024,9,18]]}}}